Skip to content

Other ways to search: Events Calendar | UTHSC News

Proposal Submission

Please contact your departmental grants administrator as soon as you know that you will be submitting a grant application so they can begin working with you to ensure you meet the submission deadline.
The Office of Sponsored Programs will provide up-to-date information and training sessions periodically (or upon request) and will post announcements via the research website and campus e-mail.

Cayuse 424

NOTE: All federal grant applications will be submitted using Cayuse 424 rather than the 424 Adobe packages unless the Funding Opportunity Announcement (FOA) requires a different means of submission.


Internal Routing
Internal routing is required prior to submission of ALL grant applications, including those with electronic submission systems that allow the PI to enter data directly into the agency website. In most instances, an institutional official must sign off on the application, either electronically or in paper form, before it is accepted by the agency.
The SP module of the Cayuse 424 system, which replaced PAMS, is used to electronically route all documents that require review and/or signature by the Office of Sponsored Programs. Log in to Cayuse SP using your net ID and password.
Proposal Deadlines
  • Five-business-days before submission
  • Proposals must be fully routed and approved in Cayuse and all documents be finalized and provided to OSP. All personnel should be fully compliant with institutional requirements for Outside Interest Disclosures and CITI COI Training.
  • No changes initiated by key personnel will be allowed for any documents. At this time only changes identified by OSP to meet institutional, or sponsor requirements will be accepted.
  • To allow the proposal to be submitted, final revisions to all documents must be provided to OSP no less than two days before submission.

It is important to note that the 5 business days are calculated from the start of the business day and must account for UTHSC closures. All documents requiring review/approval by non OSP personnel, including Letters of Support from deans, chairs and/or offices such as Access and Compliance, must be finalized prior to routing in Cayuse.

Sponsor Registration
DOD (eBRAP) submissions
UTHSC is registered in eBRAP. Investigators requiring new access to eBRAP to submit a proposal to a DOD funding opportunity should set up an account in eBRAP and request affiliation to UTHSC- please search for “Tennessee, University of, Health Science Center”. The Pre-Award team will receive automated notification of your affiliation request when you complete your request in eBRAP.
DOD pre-applications do not require institutional approval or signature and can be submitted by the PI directly in eBRAP. To ensure smooth submission of a full application, please ensure that you identify UTHSC as the institution (listed as “Tennessee, University of, Health Science Center" in menu) and select "Brenda Murrell" as the Business Official. Incorrect assignment of a pre-proposal can result in issues and delays in the review of full submissions. Full applications must be created and submitted using Cayuse SP to allow for institutional review, approval, and submission.
NIH submissions and eRA Commons Accounts
Individual investigators DO NOT need to register with UTHSC is already registered, and the "AOR" is Brenda Murrell. The UTHSC UEIis X1M1PN3KG3E7 and the DUNS# is 94-1884009. Pls submitting proposals to the NIH need to be registered in NIH Commons to apply for NIH grants. Pls who have been funded, who have applied for NIH grants, or who are NIH reviewers may already be registered. If you do not have an eRA Commons ID or if you need to affiliate an existing ID to UTHSC, please complete the eRA Commons ID request form and submit to your departmental grants administrator. After review, they should submit your request to If you are having trouble accessing eRA Commons with a UTHSC-affiliated ID, please send an email to
Sponsors using Proposal Central
Many foundations utilize the Proposal Central portal for submissions. Dependent on the sponsor, the Proposal Central forms can have different requirements such as the requirement for institutional signature and/or approval. It is important to carefully review the requirements for the specific opportunity you wish to submit to.
All proposals requiring submission via Proposal Central must be routed through Cayuse for internal routing, review, and approval prior to the sponsor’s deadline. A full, finalized PDF copy of the Proposal Central forms must be attached to the Cayuse SP prior to routing.
Proposal Central registration can be completed by the investigator and does not require institutional approval.
All applications made via Proposal Central should identify the following individuals for the following common proposal roles:
Grants Officer/ Business Official/ AOR: Brenda Murrell Associate Vice Chancellor for Research (
Fiscal Officer: Raaj Kurapati, Executive Vice Chancellor for Finance and Administration and Chief Operating Officer (
Technology Transfer Officer: Tinieka Thrailkill, University of Tennessee Research Foundation (
Letter of Intent (LOI) or Subrecipient Commitment Request
A Letter of Intent or Subrecipient Commitment may be requested when a UTHSC PI proposes to participate as a subrecipient to an external institution’s sponsored project in order to carry out a part of the project. In such cases, a Cayuse proposal, labeled as Proposal Type: Letter of Intent/Preliminary Proposal; Instrument Type: Subaward – Money In, should be routed for departmental, college, and Office of Sponsored Programs (OSP) approval. OSP requires all proposals to be received a minimum of 5 full business days prior to the sponsor deadline. Please note that OSP authorization must be obtained prior to providing internal information to an external institution. A request for letter of intent (subrecipient commitment) should contain at minimum, a statement of work the UTHSC PI will perform, detailed budget, detailed budget justification, key personnel biosketch(es) (as applicable to the funding opportunity’s guidelines), and a completed subrecipient commitment form. Full member institutions of the Federal Demonstration Partnership (FDP) can accept the FDP Subrecipient Letter of Intent or Commitment Form. External institutions may also ask UTHSC to provide authorization of it's own internal subrecipient commitment form (generally provided to the UTHSC point of contact working with the institution). Either form is acceptable. When a subrecipient arrangement is proposed with a non-FDP institution, a standard incoming Subrecipient Commitment form is generally acceptable.



Proposal Submission

May 9, 2024