Extramural Funding

Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01 CT Not Allowed) establishes an accelerated review/award process to support time-sensitive research to evaluate a new policy or program likely to influence diet, physical activity, sleep, ad/or weight thus holding the potential to lower rates of chronic diseases, particularly in populations at risk for health disparities. 2025 Application Due Dates: July 9, August 7, September 9, October 9, November 7, December 9

NIH Director's New Innovator Award (DP2 - Clinical Trial Optional): RFA-RM-25-002 supports remarkably creative early-stage investigators proposing highly innovative and high-impact projects. Single-PI applications only | PI must have Early Stage Investigator status | No preliminary data required. $475,000 direct costs per year for 5 years. Application deadline: August 19, 2025

The NIH Director’s Transformative Research Award (R01 CT opt.) supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. 2025 Application Due Date: September 3

NIH Director's Pioneer Award (DP1 - Clinical Trial Optional): RFA-RM-25-001 supports scientists with outstanding records of creativity proposing pioneering approaches to major challenges in any area of science relevant to the broad mission of NIH. Open to all career stages |  Single-PI applications only | No preliminary data required | Must be new scientific research direction. $700,000 direct costs per year for 5 years Application deadline: September 9, 2025

The NIGMS National and Regional Resources (R24 CT Not Allowed) opportunity encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional or national user base. 2025 Application Due Date: 25 September; 2026 Application Due Date: June 15

The Rare Diseases Clinical Research Consortia for the Rare Disease Clinical Research Network (U54 CT opt.) invites new and renewal applications for the Rare Diseases Clinical Research Consortia that will comprise the Rare Diseases Clinical Research Network. 2025 Application Due Date: October 15

The NCI Pathway to Independence Award (K99/R00 CT Req.) is designed for candidates proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial as part of their research and career development. If you are not planning on any of these, consider applying to this companion opportunity. 2025 Application Due Date: October 15

The NEI Clinical Research Study Planning Grant Program (R34 CT Not Allowed) supports timely planning activities and development of all materials required for the implementation of a future clinical study concerning eye and vision research. 2025 Application Due Date: October 16

Expanding the Target Landscape by Drugging the Undruggable (R21 CT Not Allowed) solicits applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes. 2025 Application Due Date: October 17; 2026 Application Due Date: May 15

The Ethical, Legal, and Social Implications Exploratory/Developmental Research Grant (R21 CT Optional) solicits applications for research projects that identify, examine, and address the ethical, legal, and social implications of advances in genomics for individuals, families, communities, groups, institutions, and society. 2025 Application Due Date: October 20

The Environmental Influences on Child Health Outcomes Cohort Data and Biospecimen Access (X01 CT Not Allowed) solicits applications to access limited identifiable data or biospecimens from the ECHO Cohort to study high-priority areas of maternal and child health. 2025 Application Due Date: November 4; 2026 Application Due Dates: March 1, July 1, November 4

The Tobacco Regulatory Science Small Grant Program for New Investigators (R03 CT opt.) helps provide scientific evidence to inform the implementation of the Family Smoking Prevention and Tobacco Control Act, which grants the FDA CTP authority to regulate tobacco product manufacturing, distributing, and marketing. 2025 Application Due Date: 18 November; 2026 Application Due Date: 14 July

The New Investigator Gateway Awards for Collaborative T1D Research (R03 CT Not Allowed) promote extramural basic and clinical biomedical research improving the understanding of the mechanisms underlying disease leading to improved preventions, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Letter of Intent Due Date: February 6, 2026

If interested in Congressionally Directed Medical Research Programs,  the Office of Research Development encourages you to visit the subject area pages for the most up-to-date information as some funding opportunities are currently open while others are simply anticipated. Should you have any questions about these or other opportunities, please reach out to ORD.

LOI Deadline: 30 days before the application due date.

Application Due Date(s): August 6, 2025; August 6, 2026