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Jonathan H. Jaggar, PhD

Maury Bronstein Endowed Professor

847 Monroe Ave
Johnson Building
Memphis, TN 38163
Phone: 901.448.1208
Fax: 901.448.7126

The Jaggar Cardiovascular Research Laboratory


Coventry University, Coventry, UK, BS, Applied Biology, 
University of Sheffield, Sheffield, UK, 1991-1995, PhD, Potassium Channels
University of Vermont, Burlington, VT, 1995-1999, Postdoc., Vascular Physiology

Research Interest

My research program investigates the physiological regulation of arterial contractility and systemic blood pressure by ion channels expressed in smooth muscle and endothelial cells. My laboratory also examines pathological alterations in ion channels that are associated with cardiovascular diseases, including hypertension and stroke. Ion channels that we study include SK, TRP polycystin and ANO1. Research in my laboratory uses a wide variety of molecular, biochemical, cellular, and functional techniques and cardiovascular disease and genetic animal models. Methods used in the laboratory include inducible cell-specific gene knockout and cardiovascular disease models, RT-PCR, Western blotting, biotinylation, FRET, RNAi, co-IP, immunofluorescence, super resolution microscopy, patch-clamp electrophysiology, membrane potential recording, intracellular Ca2+imaging, arterial myography and blood pressure telemetry.

Representative Publications

  1. Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH.  Dynamic Regulation of β1 subunit Trafficking Controls Vascular Contractility.  Proc Natl Acad Sci USA 2014; 111(6):2361-2366.  PMID: 24464482
  2. Evanson, KW, Bannister JP, Leo MD, Jaggar JH.  LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.  Circ Res 2014; 115(4):423-341.  PMID: 24906643
  3. Kidd MW, Leo MD, Bannister JP, Jaggar JH.  Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells. Science Signaling 2015; 8(390):ra83. doi: 10.1126/scisignal.aac5128. PMID: 26286025
  4. Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA and Jaggar JH. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Science Signaling 2017; 10, eaah5417. PMID: 28487419.
  5. Zhai X, Leo, MD and Jaggar JH. Endothelin-1 stimulates vasoconstriction through Rab11A serine 177 phosphorylation. Circ Res 2017; 121(6):650-661. doi: 10.1161/CIRCRESAHA.117.311102 PMID: 28696251.
  6. Bulley S*, Fernández-Peña C*, Hasan R, Leo MD, Muralidharan P, MacKay CE, Evanson CW, Moreira-Junior L, Mata-Daboin A, Burris SK, Wang Q, Kuruvilla KP and Jaggar JH. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. eLIFE 2018; 4;7. pii: e42628. doi: 10.7554/eLife.42628. * contributed equally. PMID: 30511640.
  7. Hasan R*, Leo MD*, Muralidharan P, Mata-Daboin A, Yin W, Bulley S, Fernandez-Peña C, MacKay C and Jaggar JH. SUMO1-modification of PKD2 channels regulates arterial contractility. Proc. Natl. Acad. Sci. USA 2019; 116 (52) 27095-27104. PMID:31822608. * contributed equally.
  8. MacKay CE, Leo MD, Fernández-Peña C, Hasan R, Yin W, Mata-Daboin A, Bulley S, Gammons J, Mancarella S, Jaggar JH. Intravascular flow stimulates PKD2 (Polycystin-2) channels in endothelial cells to reduce blood pressure. eLife 2020; 9:e56655. doi: 10.7554/eLife.56655. PMID: 32364494.
  9. MacKay CE, Floen M, Leo MD, Hasan R, Garrud TAC, Fernández-Peña C, Singh, P, Malik, KU and Jaggar JH. A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation. eLife 2022 Mar 1;11:e74765. doi: 10.7554/eLife.74765. PMID: 35229718.

Additional Information

Dec 20, 2023