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Jonathan H. Jaggar, PhD

Maury Bronstein Endowed Professor

847 Monroe Ave
Johnson Building
Memphis, TN 38163

jjaggar@uthsc.edu
Phone: 901.448.1208
Fax: 901.448.7126

The Jaggar Cardiovascular Research Laboratory

Education

Coventry University, Coventry, UK, BS, Applied Biology, 
University of Sheffield, Sheffield, UK, 1991-1995, PhD, Potassium Channels
University of Vermont, Burlington, VT, 1995-1999, Postdoc., Vascular Physiology

Research Interest

My research program investigates the physiological regulation of arterial contractility and systemic blood pressure by ion channels expressed in smooth muscle and endothelial cells. My laboratory also examines pathological alterations in ion channels that are associated with cardiovascular diseases, including hypertension and stroke. Ion channels that we currently study include TRP, KV, ANO1 and CaV1.2 proteins.  We use a broad range of techniques that incorporates the use of a molecular, biochemical, cellular, and functional approaches, making the research translational. Methods used in the laboratory include novel cell-specific gene knockout and cardiovascular disease models, RT-PCR, Western blotting, biotinylation, FRET, RNAi, co-IP, immunofluorescence, patch-clamp electrophysiology, membrane potential recording, intracellular Ca2+imaging, arterial myography and blood pressure telemetry.

Representative Publications

  1. Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH.  Dynamic Regulation of β1 subunit Trafficking Controls Vascular Contractility.  Proc Natl Acad Sci USA 2014; 111(6):2361-2366.  PMID: 24464482
  2. Evanson, KW, Bannister JP, Leo MD, Jaggar JH.  LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.  Circ Res 2014; 115(4):423-341.  PMID: 24906643
  3. Kidd MW, Leo MD, Bannister JP, Jaggar JH.  Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells. Science Signaling 2015; 8(390):ra83. doi: 10.1126/scisignal.aac5128. PMID: 26286025
  4. Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA and Jaggar JH. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Science Signaling 2017; 10, eaah5417. PMID: 28487419.
  5. Zhai X, Leo, MD and Jaggar JH. Endothelin-1 stimulates vasoconstriction through Rab11A serine 177 phosphorylation. Circ Res 2017; 121(6):650-661. doi: 10.1161/CIRCRESAHA.117.311102 PMID: 28696251.
  6. Bulley S*, Fernández-Peña C*, Hasan R, Leo MD, Muralidharan P, MacKay CE, Evanson CW, Moreira-Junior L, Mata-Daboin A, Burris SK, Wang Q, Kuruvilla KP and Jaggar JH. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. eLIFE 2018; 4;7. pii: e42628. doi: 10.7554/eLife.42628. * contributed equally. PMID: 30511640.

Additional Information

Last Published: Sep 27, 2019