Resources
Service Inquiries
The UTHSC RBL welcomes collaborative partnerships with internal, external, commercial and government agencies. Investigators in academic, not-for-profit organizations, industry, and government studying biodefense and emerging infectious diseases may request the use of biocontainment laboratories. Refer to our FAQs below for more information.
If you are interested in performing collaborative or contracted studies, or in using one or more of our RBL services, initiate the process by filling out our service inquiry form. We will respond to you are quickly as possible.
SERVICE INQUIRY FORMWho to Contact
|
Colleen Jonsson, PhD RBL Director cjonsson@uthsc.edu |
Elizabeth Fitzpatrick, PhD Associate Director efitzpat@uthsc.edu |
Dong Yang, PhD Program Manager dyang17@uthsc.edu |
FAQs
What are our main areas of focus?
What type research services does the UTHSC RBL provide?
Can the UTHSC RBL accommodate GLP or GMP studies?
What animal capabilities, including species and containment level(s) are provided?
What animal models, including species, disease, and delivery methods are available?
What are our imaging capabilities?
What major equipment is available?
Answers
What are our main areas of focus?
- To test and evaluate small molecules, vaccines, and diagnostics to protect the general population from infectious diseases and bioterrorism.
- To develop small animal models for testing.
How do I get started?
Simply fill out our service inquiry form. You may also contact the RBL Director, Colleen, Jonsson, or the Associate Director, Elizabeth Fitzpatrick, or the Program Manager, Dong Yang for further information.
Who can use the RBL?
Investigators in academia, not-for-profit organizations, industry, and government studying biodefense and emerging infectious diseases may request the use of biocontainment laboratories.
What type research services does the UTHSC RBL provide?
Antiviral Discovery & Development
- High Throughput Screening
- Titer Reductions
- Time of Addition
- Evaluation of Small Molecules for
- Safety and Efficacy in Small Animals
- Pharmacokinetics and Pharmacodynamics (LC-MS available in BSL-3 containment suite)
Vaccine & Biologics Discovery
- Neutralizing Antibody Titers
- Immunoglobulin Quantitation and Subtyping
- B and T Cell Responses
- Immunophenotyping
- Evaluation in Small Animals
Pathogenesis Discovery
- Biomarkers
- Sequencing
- High Throughput Biology
- Evaluation in Small Animal Models
- Virus Isolation
- Identification of pathogens in animal, human, and environmental samples
Immunology & Biomarker Discovery
- Hematology
- Clinical Chemistry
- Multiplex Assays
- ELISpot
- Spectral Cytometer
- Cell Sorter
- Evaluation in Small Animal Models
Can the UTHSC RBL accommodate GLP or GMP studies?
Yes, we are GLP capable and operational in one ABSL-2 or ABSL-3 suite.
What animal capabilities, including species and containment level(s) are provided?
Containment available at ABSL-2 and -3
- Mice
- Rats
- Cotton rat
- Guinea pigs
- Hamsters
- Ferrets
- Other small animals - on request
What animal models, including species, disease, and delivery methods are available?
- Influenza BSL-2 strains, HPAIV (intranasal)
- Old World hantaviruses
- Severe acute respiratory syndrome Coronavirus 1 (SARS CoV-1)
- Severe acute respiratory syndrome Coronavirus 2 (SARS CoV-2)
- Middle-East respiratory syndrome Coronavirus (MERS CoV)
- Respiratory Syncytial virus (intranasal)
- Venezuelan equine encephalitis viruses (subcutaneous and intranasal)
- Western equine encephalitis viruses (subcutaneous and intranasal)
- Eastern equine encephalitis viruses (subcutaneous and intranasal)
- Leptospira interrogans; Intraperitoneal, conjunctival, transdermal
- Mycobacterium tuberculosis (intranasal)
- Methicillin-resistant Staphylococcal aureus
- Staphylococcus aureus (laboratory and clinical strains)
- Streptococcus pneumoniae (laboratory and clinical strains)
- Co-infection model with influenza and Streptococcus pneumoniae or Staphylococcus aureus
- Saccharopolyspora rectivirgula
- Other- available on request
What are our imaging capabilities?
- Xenogen IVIS spectrum
- CT
- ECHO
What major equipment is available?
- Respons®910VET Chemistry Analyzer (RBL-ABSL-3)
- X•pedite™ HEM³ VET Hematology Analyzer (RBL-ABSL-3)
- Agilent Bioanalyzer (RBL-BSL-3)
- QuantStudio 6 real-time PCR (96- and 384-well blocks) (RBL-BSL-3)
- Biotek FX (RBL-BSL-3)
- Eppendorf PCR (RBL-BSL-3)
- Synergy (RBL-BSL-2; RBL-BSL-3; RBL ABSL-3)
- Biotek Plate Washer (RBL-BSL-2)
- EnVision (RBL-BSL-3; RBL-BSL-2)
- Luminex® 200 (RBL-BSL-2)
- Magpix® System with Milliplex® Analyst software (RBL-BSL-3)
- QBIT (RBL-BSL-3)
- Mindray ultrasound system with an Ultrasonic Transducer (RBL-ABSL-3)
- Vevo 3100 Ultrasound (RBL ABSL-3)
- Illumina MiSeq (RBL-BSL-2- in select agent space)
- IVIS (RBL-ABSL-3)
- Janus robot (MSB617-BSL-2)
- Molecubes CT (RBL ABSL-3)
- Cytek Aurora Spectral Cytometer (RBL-BSL-2- in select agent space)
- C.T.L. EliSpot Analyzer (RBL-BSL-3)
- Miltenyi Biotec BLAZE (RBL-BSL-2- in select agent space)
- 10 X Genomics Chromium X (RBL-BSL-3)
- Olympus APEX (RBL-BSL-3)
- Emulate, Inc. - Zoe & Orb (RBL-BSL-3 – currently at BSL-2 as conditions set up)
- Miltenyi Biotech - MACSQuant Tyto (RBL-BSL-3)
- AB Sciex, LLc - QTRAP 5500+ mass spectrometer (RBL-BSL-3)
- Yokogawa CQ1 system (RBL-BSL-2- in select agent space)
- KingFisher (RBL-BSL-3)
- EVOS fluorescent microscope (RBL-BSL-3)
- Refrigerated Centrifuges with biocontainment rotors in most rooms (RBL-BSL-3)
- -80C Freezers (RBL-BSL-3)
- Beadmills (RBL-BSL-3)
- Phase microscopes (RBL-BSL-3)
- CO2 incubators (RBL-BSL-3)
- SCIEX QTRAP 5500+ LC-MS/MS system (RBL-BSL-3)
Other UTHSC shared resources?
- Proteomic MS facility
- Solid deep sequencing systems
- Affymetrix-based global transcriptomic facility
- Confocal microscopy
- Transmission and scanning EM facility
- BXD mice platform
- Gnotobiotic mouse facility
Need iLab Registration?
iLab is a web-based system highly customized for academic shared resources that will streamline research by making the process of requesting equipment reservations, completing order requests, and billing core users quicker and easier.
First time? Not a UTHSC user? Create an iLab account now.
If you need further assistance or have trouble with registration, please contact Steve Wills at jswills@uthsc.edu.
Need a contract/agreement?
UTHSC is a fee-for-service facility, we have no entitlement to your intellectual property or publications. If you need to set up an agreement - MTA, NDA (CDA), or RSA - before studying with the RBL, please fill out the basic information in the templates below and submit them here. You can also use a template agreement of your organization.
If you need further assistance or have a question, please contact Tempie Sydes at temlsyde@uthsc.edu.
Need to pay?
Upon study completion, you will receive an invoice for RBL services at UTHSC. Please remit payment (by check) to:
UT Health Science Center
Regional Biocontainment Laboratory
Attn: Natalie Smith
901 Monroe Avenue
Memphis, TN 38163
If you wish to make payment via ACH wire transfer, please find the UT banking institution and W-9 form. For international wire transfers, use the UT Swift Code# FTBMUS44.
For further inquiries about your payment, please contact Natalie Smith at nsmith@uthsc.edu.