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Ade Adebiyi, PhD

Professor of Physiology
Faculty and Member, UTHSC Center for Sickle Cell Disease

University of Tennessee Health Science Center
Department of Physiology
Coleman Building, 956 Court Avenue, Room C211
Memphis, TN 38163, USA
Phone: 901.448.1868

Adebiyi Laboratory


  • College of Medicine, University of Lagos, Nigeria; B.Sc. (Hons): 1996
  • National University of Singapore, Singapore; Ph.D.: 2004
  • University of Tennessee Health Science Center, Memphis TN; Postdoctoral Trainee: 2009
    **American Heart Association Postdoctoral Fellow (07/2006-06/2008)

Research Interest

Dr. Adebiyi’s research team utilizes an integrative approach, including molecular, biochemical, electrophysiology, imaging, and whole animal methodologies to investigate ion channels, G protein-coupled receptors, and regulatory proteins that control vascular and renal function. Recent NIH-funded research projects in Dr. Adebiyi’s laboratory use preclinical large animal models to explore the physiology and pathophysiology of neonatal renal microcirculation.

Selected Publications

1. Park F, Soni H, Pressly JD, ADEBIYI A. Acute hydroxyurea treatment reduces tubular damage following bilateral ischemia-reperfusion injury in a mouse model of sickle cell disease. Biochemical and Biophysical Research Communications. 2019; 515:72-76.

2. **Soni H, Peixoto-Neves D, Olushoga MA, ADEBIYI A. Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs. Clinical Science. 2019; 133(9) CS20180815.

**Highlighted by Faculty of 1000 [In F1000Prime, 22 May 2019; 10.3410/f.735566776.793560089].

3. Soni H, Amartey PK, Yakimkova T, Matthews AT, Read RW, Buddington RK, ADEBIYI A. Early onset of renal oxidative stress in small for gestational age newborn pigs. Redox Report2019; 24:10-16.

4. Peixoto-Neves D, Soni H, ADEBIYI A. CGRPergic nerve TRPA1 channels contribute to epigallocatechin gallate-induced neurogenic vasodilation. ACS Chemical Neuroscience. 2019; 10:216-220.

5. Soni H, Matthews AT, Pallikkuth S, Gangaraju R, ADEBIYI A. γ-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling. Journal of Cellular and Molecular Medicine. 2019; 23:260-270.

6. Soni H, Kaminski D, Gangaraju R, ADEBIYI A. Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding. Renal Failure. 2018; 40:314-322.

7. Soni H, ADEBIYI A. Urotensin II-induced store-operated Ca2+ entry contributes to glomerular mesangial cell proliferation and extracellular matrix protein production under high glucose conditions. Scientific Reports 2017; 7:18049.

8. Soni H, Peixoto-Neves D, Buddington RK, ADEBIYI A. Adenosine A1 receptor-operated calcium entry in afferent arterioles is dependent on postnatal maturation of TRPC3 channels. American Journal of Physiology. Renal Physiology 2017; 313: F1216-F1222.

9. Soni H, Peixoto-Neves D, Matthews AT, ADEBIYI A. TRPV4 channels contribute to neonatal renal myogenic response. American Journal of Physiology. Renal Physiology 2017; 313: F1136-F1148.

10. Soni H, ADEBIYI A. Early polymicrobial sepsis in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis. Renal Failure 2017; 39: 83-91.

11. Soni H, ADEBIYI A. TRPC6-mediated activation of the calcineurin/NFAT and FasL/Fas signaling pathways promote neonatal glomerular mesangial cell apoptosis. Scientific Reports 2016; 6: 29041.

12. ADEBIYI A, Soni H, John TA, Yang F. Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells. Experimental Cell Research 2014; 324:92-104.

13. ADEBIYI A. RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells. Journal of Cellular Physiology 2014; 229:502-511.

14. **ADEBIYI A, Narayanan D, Jaggar JH. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. Journal of Biological Chemistry 2011; 286:4341-4348.

** Science Signaling Editor’s Choice:  Gough NR. Coupled by Caveolin. Science Signaling 2011; 4 (160): ec50.

15. ADEBIYI A, Zhao G, Narayanan D, Thomas-Gatewood CM, Bannister JP, Jaggar JH.  Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility. Circulation Research 2010; 106:1603-1612.

My Bibliography



NIH/NIDDK and the American Heart Association

May 26, 2022