James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Hiatt SM, Neu MB, Ramaker RC, Hardigan AA, Prokop JW, Hancarova M, Prchalova D, Havlovicova M, Prchal J, Stranecky V, Yim DKC, Powis Z, Keren B, Nava C, Mignot C, Rio M, Revah-Politi A, Hemati P, Stong N, Iglesias AD, Suchy SF, Willaert R, Wentzensen IM, Wheeler PG, Brick L, Kozenko M, Hurst ACE, Wheless JW, Lacassie Y, Myers RM, Barsh GS, Sedlacek Z, Cooper GM. De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay. PLoS Genet. 2018 Nov 30;14(11):e1007671. doi: 10.1371/journal.pgen.1007671. eCollection 2018 Nov. PubMed PMID: 30500825; PubMed Central PMCID: PMC6291162.
  • Rentz AM, Skalicky AM, Liu Z, Dunn DW, Frost MD, Nakagawa JA, Prestifilippo J, Said Q, Wheless JW. Burden of renal angiomyolipomas associated with tuberous sclerosis complex: results of a patient and caregiver survey. J Patient Rep Outcomes. 2018 Jul 13;2:30. doi: 10.1186/s41687-018-0055-4. eCollection 2018 Dec. PubMed PMID: 30294710; PubMed Central PMCID: PMC6091699.
  • Moharramipour A, Mostame P, Hossein-Zadeh GA, Wheless JW, Babajani-Feremi A. Comparison of statistical tests in effective connectivity analysis of ECoG data. J Neurosci Methods. 2018 Oct 1;308:317-329. doi: 10.1016/j.jneumeth.2018.08.026. Epub 2018 Sep 3. PubMed PMID: 30189285.
  • Wheless JW, Phelps SJ. A Clinician's Guide to Oral Extended-Release Drug Delivery Systems in Epilepsy. J Pediatr Pharmacol Ther. 2018 Jul-Aug;23(4):277-292. doi: 10.5863/1551-6776-23.4.277. Review. PubMed PMID: 30181718; PubMed Central PMCID: PMC6117810.
  • Wheless JW, Gienapp AJ, Ryvlin P. Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav. 2018 Nov;88S:2-10. doi: 10.1016/j.yebeh.2018.06.032. Epub 2018 Jul 13. Review. PubMed PMID: 30017839.
  • Babajani-Feremi A, Noorizadeh N, Mudigoudar B, Wheless JW. Predicting seizure outcome of vagus nerve stimulation using MEG-based network topology. Neuroimage Clin. 2018 Jun 18;19:990-999. doi: 10.1016/j.nicl.2018.06.017. eCollection 2018. PubMed PMID: 30003036; PubMed Central PMCID: PMC6039837.

View more references (pubmed link)