James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Mudigoudar B, Weatherspoon S, Wheless JW. Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies. Semin Pediatr Neurol. 2016 May;23(2):167-79. doi: 10.1016/j.spen.2016.06.003. Epub 2016 Jun 4. PubMed PMID: 27544474.
  • Babajani-Feremi A, Narayana S, Rezaie R, Choudhri AF, Fulton SP, Boop FA, Wheless JW, Papanicolaou AC. Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation. Clin Neurophysiol. 2016 Mar;127(3):1822-36. doi: 10.1016/j.clinph.2015.11.017. Epub 2015 Nov 26. PubMed PMID: 26679420.
  • Rivas-Coppola MS, Shah N, Choudhri AF, Morgan R, Wheless JW. Chronological Evolution of Magnetic Resonance Imaging Findings in Children With Febrile Infection-Related Epilepsy Syndrome. Pediatr Neurol. 2016 Feb;55:22-9. doi: 10.1016/j.pediatrneurol.2015.09.003. Epub 2015 Sep 25. PubMed PMID: 26597039.
  • Wheless JW. Use of the mTOR inhibitor everolimus in a patient with multiple manifestations of tuberous sclerosis complex including epilepsy. Epilepsy Behav Case Rep. 2015 Aug 12;4:63-6. doi: 10.1016/j.ebcr.2015.06.008. eCollection 2015. PubMed PMID: 26543807; PubMed Central PMCID: PMC4543076.
  • Brittain ST, Wheless JW. Pharmacokinetic simulations of topiramate plasma concentrations following dosing irregularities with extended-release vs. immediate-release formulations. Epilepsy Behav. 2015 Nov;52(Pt A):31-6. doi: 10.1016/j.yebeh.2015.08.029. Epub 2015 Sep 24. PubMed PMID: 26409125.
  • Alford EL, Wheless JW, Phelps SJ. Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients. J Pediatr Pharmacol Ther. 2015 Jul-Aug;20(4):260-89. doi: 10.5863/1551-6776-20.4.260. Review. PubMed PMID: 26380568; PubMed Central PMCID: PMC4557718.

View more references (pubmed link)