James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Divison of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless


  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Zoghbi HY, Gennarino VA, Alcott CE, Chen CA, Chaudhury A, Gillentine MA, Rosenfeld JA, Parikh S, Wheless JW, Roeder ER, Horovitz DD, Roney EK, Smith JL, Cheung SW, Li W, Neilson JR, Schaaf CP. NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation. Elife. 2015 Aug 27;4. doi: 10.7554/eLife.10782. [Epub ahead of print] PubMed PMID: 26312503.
  • Patterson AL, Mudigoudar B, Fulton S, McGregor A, Poppel KV, Wheless MC, Brooks L, Wheless JW. SmartWatch by SmartMonitor: Assessment of Seizure Detection Efficacy for Various Seizure Types in Children, a Large Prospective Single-Center Study. Pediatr Neurol. 2015 Jul 15. pii: S0887-8994(15)00332-X. doi: 10.1016/j.pediatrneurol.2015.07.002. [Epub ahead of print] PubMed PMID: 26272007.
  • Choudhri AF, Patel RM, Siddiqui A, Whitehead MT, Wheless JW. Cortical Activation Through Passive-Motion Functional MRI. AJNR Am J Neuroradiol. 2015 Jul 30. [Epub ahead of print] PubMed PMID: 26228890.
  • Rivas-Coppola MS, Patterson AL, Morgan R, Wheless JW. Bupropion Overdose Presenting as Status Epilepticus in an Infant. Pediatr Neurol. 2015 Sep;53(3):257-61. doi: 10.1016/j.pediatrneurol.2015.05.018. Epub 2015 Jun 14. PubMed PMID: 26183178.
  • Caron E, Wheless CE, Patters AB, Wheless JW. The charges for seizures in the pediatric emergency room: a single center study. Pediatr Neurol. 2015 May;52(5):517-20. doi: 10.1016/j.pediatrneurol.2015.02.010. Epub 2015 Feb 18. PubMed PMID: 25882079.
  • Rentz AM, Skalicky AM, Pashos CL, Liu Z, Magestro M, Pelletier CL, Prestifilippo JA, Nakagawa J, Frost MD, Dunn DW, Wheless JW. Caring for Children With Tuberous Sclerosis Complex: What Is the Physical and Mental Health Impact on Caregivers? J Child Neurol. 2015 Apr 2. pii: 0883073815575364. [Epub ahead of print] PubMed PMID: 25838447.

View more references (pubmed link)