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James W. Wheless, MD

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: 901.287.5207
Fax: 901.287.5325
Email: James W. Wheless


  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Loring DW, Meador KJ, Shinnar S, Gaillard WD, Wheless JW, Kessler SK, Conry JA, Berl MM, Burns TG, Glauser TA, Kinkead B, Cnaan A. Differential antiseizure medication sensitivity of the Affective Reactivity Index: A randomized controlled trial in new-onset pediatric focal epilepsy. Epilepsy Behav. 2019 Dec 6;102:106687. doi: 10.1016/j.yebeh.2019.106687. [Epub ahead of print] PubMed PMID: 31816478.
  • Rossi GC, Patterson AL, McGregor AL, Wheless JW. Intractable Generalized Epilepsy and Autosomal Dominant Hypocalcemia: A Case Report. Child Neurol Open. 2019 Sep 19;6:2329048X19876199. doi: 10.1177/2329048X19876199. eCollection 2019. PubMed PMID: 31763346; PubMed Central PMCID: PMC6852356.
  • Arya R, Babajani-Feremi A, Byars AW, Vannest J, Greiner HM, Wheless JW, Mangano FT, Holland KD. A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation. Epilepsy Behav. 2019 Oct;99:106455. doi: 10.1016/j.yebeh.2019.106455. Epub 2019 Aug 13. PubMed PMID: 31419636.
  • Wheless JW, Meng TC, Van Ess PJ, Detyniecki K, Sequeira DJ, Pullman WE. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: An open-label extension trial. Epilepsia. 2019 Sep;60(9):1809-1819. doi: 10.1111/epi.16300. Epub 2019 Jul 29. PubMed PMID: 31353457.
  • Babajani-Feremi A, Fulton SP, Holder CM, Choudhri AF, Boop FA, Wheless JW. Localization of Expressive Language Cortex in a 2-Year-Old Child Using High-Gamma Electrocorticography. J Child Neurol. 2019 Nov;34(13):837-841. doi: 10.1177/0883073819863999. Epub 2019 Jul 24. PubMed PMID: 31339411.
  • Wheless MC, Takwi AA, Almoazen H, Wheless JW. Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a Single-Center, Open-Label Trial. Child Neurol Open. 2019 Apr 14;6:2329048X19835047. doi: 10.1177/2329048X19835047. eCollection 2019. PubMed PMID: 31259191; PubMed Central PMCID: PMC6589944.

View more references (pubmed link)

May 26, 2022