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Kazuko Sakata, PhD

Associate Professor
Department of Pharmacology
Department of Psychiatry

The University of Tennessee Health Science Center
874 Union Ave., Room 430 Crowe Research Building
Memphis, TN 38163
Phone: 901.448.2662
Fax: 901.448.7206
Email: Kazuko Sakata


  • PhD Institution: Osaka University School of Medicine, Osaka, Japan
  • Postdoctoral: Neural Development and Plasticity, National Institutes of Health

Research Interests

Our current projects in my laboratory focus on studying the roles of gene regulation of BDNF (Brain Derived Neurotrophic Factor) in depression and anxiety, using genetically modified mice. We study from gene to behavior, using molecular and biochemical, electrophysiological, and behavioral techniques.

Representative Publications

  • Li L, Ismael S, Nasoohi S, Sakata K, Liao FF, McDonald MP, Ishrat T. Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer's Disease Brain. J Alzheimers Dis. 2019;68(1):255-265. doi: 10.3233/JAD-180814. PubMed PMID: 30741672.
  • Dong BE, Xue Y, Sakata K. The effect of enriched environment across ages: A study of anhedonia and BDNF gene induction. Genes Brain Behav. 2018 Nov;17(8):e12485. doi: 10.1111/gbb.12485. Epub 2018 May 31. PubMed PMID: 29717802; PubMed Central PMCID: PMC6214784.
  • Sakata K, Overacre AE. Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. J Neurochem. 2017 Oct;143(1):49-64. doi: 10.1111/jnc.14129. Epub 2017 Aug 16. PubMed PMID: 28722769; PubMed Central PMCID: PMC5672805.
  • Kim E, Sakata K, Liao FF. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation. PLoS Genet. 2017 Jul 5;13(7):e1006849. doi: 10.1371/journal.pgen.1006849. eCollection 2017 Jul. PubMed PMID: 28678786; PubMed Central PMCID: PMC5517072.
  • Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF. Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region. Mol Psychiatry. 2017 Jul;22(7):935. doi: 10.1038/mp.2017.125. PubMed PMID: 28638149.
  • Jha S, Dong BE, Xue Y, Delotterie DF, Vail MG, Sakata K. Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV. Transl Psychiatry. 2016 Sep 20;6(9):e896. doi: 10.1038/tp.2016.160. PubMed PMID: 27648918; PubMed Central PMCID: PMC5048201.

View more references (pubmed link)

May 26, 2022