Mohammad Moshahid Khan PhD
Assistant Professor
Department of Neurology
Departtment of Physical Therapy
University of Tennesse Health Science Center
855 Monroe Ave
Link Building, Rm# 432
Memphis, TN 38163
Phone: 901.448.3180
Email: Mohammad Moshahid Khan
Education
- PhD Institution: Hamdard University, Department of Toxicology, New Delhi, India
- Postdoctoral: University of Iowa, Department of Internal Medicine, Iowa City, IA USA
Research Interests
My research is focused on defining the contribution of DNA repair deficits to neurodegenerative diseases, particularly, Alzheimer’s disease and Parkinson’s disease. DNA damage has been extensively studied in mitotic cells, including neural progenitors, its role in postmitotic neurons during neurodegenerative conditions remains unclear. Among possible DNA damage, DNA double-strand breaks are the most harmful and perilous type of DNA damage as they markedly impact genome integrity, transcriptional activity, as well as neuronal and synaptic function. However, there is a gap in understanding the onset and progression of the neurodegenerative disease from DNA double-strand breaks to the molecular and cellular abnormalities and motor/cognitive deficits. We have a long-standing interest and years of experience in DNA damage repair mechanisms in neurological disorders and plan to address this important gap in the current knowledge using human postmortem brain tissues and experimental models of neurological diseases. My long-term research is committed to unraveling the mysteries of neurological diseases and to discovering new treatments for these incurable diseases.
Representative Publications
- Shukla PK, Delotterie DF, Xiao J, Pierre JF, Rao R, McDonald MP, Khan MM. Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease. Cells 2021, 10(4), 779. https://doi.org/10.3390/cells10040779
- Thadathil N, Xiao J, Hori R, Alway SE, Khan MM. Brain selective estrogen treatment protects dopaminergic neurons and preserves behavioral function in the MPTP-induced mouse model of Parkinson’s disease. Journal of Neuroimmune Pharmacology. 2020 PMID: 33221984
- Thadathil N, Delotterie DF, Xiao J, Hori R, McDonald MP, Khan MM. DNA Double-Strand Break Accumulation in Alzheimer's Disease: Evidence from Experimental Models and Postmortem Human Brains. Mol Neurobiol. 2021 Jan;58(1):118-131. PMID: 32895786
- Ahmad A, Patel V, Xiao J, Khan MM. The Role of Neurovascular System in Neurodegenerative Diseases. Mol Neurobiol. 2020 Nov;57(11):4373-4393 PMID: 32725516
- Calame DJ, Xiao J, Khan MM, Hollinsworth TJ, Xue Y, Person AL, LeDoux MS. Presynaptic PRRT2 deficiency causes cerebellar dysfunction and paroxysmal kinesigenic dyskinesia. Neuroscience. 2020 Nov 10;448:272-286.. PMID: 32891704
- Ferrandi PJ, Khan MM, Paez HG, Pitzer CR, Alway SE, Mohamed JS. Transcriptome Analysis of Skeletal Muscle Reveals Altered Proteolytic and Neuromuscular Junction Associated Gene Expressions in a Mouse Model of Cerebral Ischemic Stroke. Genes (Basel). 2020 Jun 30;11(7). PMID: 32629989; PMCID: PMC7397267
- Doxtater K, Tripathi MK, Khan MM. Recent advances on the role of long non-coding RNAs in Alzheimer’s disease. Neural Regen Res 2020. 15(12):2253-2254