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VCR's Distinguished Lecture Series

The VCR's Distinguished Lecture Series was created in an effort to educate and help the research community stay abreast on the world’s most pressing research topics.

During each of their visits, invited lecturers will meet with UTHSC administration, faculty and staff to share ideas and foster collaborative efforts centered on education, research and entrepreneurial ventures. They will also deliver a scientific lecture to the UTHSC community.

April 23, 2020

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Nevan Krogan, PhD
Professor, Department of Cellular and Molecular Pharmacology and Director, Quantitative Biosciences Institute, University of California-San Francisco
12:00pm in the Freeman Auditorium (930 Madison Ave., 3rd Floor)

 Talk Title: "Using Systems Approaches to Understand Disease"

There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent work that explicitly combine data from systems and structural biological approaches is having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks and ultimately lead to changes in organismal fitness. Our group aims to create a stronger bridge between these areas primarily using three types of data: genetic interactions, protein-protein interactions and post-translational modifications.  Protein structural information helps to prioritize and functionally understand these large-scale datasets; conversely global, unbiasedly collected datasets helps inform the more mechanistic studies. Our efforts in this respect have been focused on model organisms, but more recently in mammalian cells, with a particular focus on cancer, psychiatric disorders and pathogenesis.


Dr. Nevan J. Krogan is a professor in the Department of Cellular and Molecular Pharmacology at the University of California-San Francisco (UCSF) as well as a senior investigator at the J. David Gladstone Institutes. He is also the Director of the Quantitative Biosciences Institute (QBI) at UCSF, which focuses on developing and using quantitative approaches to study basic biological mechanisms, often related to disease areas. Dr. Krogan's research is focused on using quantitative system approaches to help understand complex biological and biomedical problems, with a focus on infectious disease, cancer and psychiatric disorders. He serves as Director of The HARC Center, an NIH-funded collaborative group that focuses on the structural characterization of HIV-human protein complexes. Dr. Krogan is also the co-Director of three Cell Mapping initiatives, the Cancer Cell Mapping Initiative (CCMI), the Host Pathogen Map Initiative (HPMI) and the Psychiatric Cell Map Initiative (PCMI).  These initiatives map the gene and protein networks in healthy and diseased cells. These maps are now being used to better understand disease and provide novel therapies to fight them. He has authored over 250 papers in the fields of genetics and molecular biology and has given over 300 lectures and seminars nationally and internationally. He is a Searle Scholar, a Keck Distinguished Scholar and was recently awarded the Roddenberry Prize for Biomedical Research.

To see an archive of past presentations, please see the Recorded Lectures webpage.

Last Published: Mar 6, 2020