Skip to content

Bob M. Moore II, PhD

Professor
Department of Pharmaceutical Sciences

The University of Tennessee Health Science Center
874 Union Avenue, Room 327D
Memphis, TN 38163
Tel: 901.448.6085
Fax: 508.448.6828
Email: Bob M. Moore

Education

  • BS in Chemistry, Indiana State University, 1983
  • MS in Chemistry, Indiana State University, 1989
  • PhD (Medicinal Chemistry), University of Kansas, 1995

Research Interests

Research in Dr. Moore's lab integrates synthetic organic chemistry, computational chemistry and biological assays aimed at developing new chemotherapeutic entities. The current areas of research include:

  1. Development of cannabinoid receptor (CB1 and CB2) agonist and antagonist.
  2. Development of novel therapies for combat causality care with emphasis on hemorrhagic shock and hemostasis.
  3. Development of GPRC directed anti-neoplastic agents.
  4. Combination drug therapies for the treatment of sepsis, stroke and ischemic brain conditions.

Representative Publications

  • Honig MG, Del Mar NA, Henderson DL, Ragsdale TD, Doty JB, Driver JH, Li C, Fortugno AP, Mitchell WM, Perry AM, Moore BM, Reiner A. Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene. Exp Neurol. 2019 Dec;322:113063. doi: 10.1016/j.expneurol.2019.113063. Epub 2019 Sep 10. PubMed PMID: 31518568.
  • Kay S, Moore BM, Moore L, Seco M, Barnes C, Marshman D, Grieve SM, Celermajer DS. Rugby Player's Aorta: Alarming Prevalence of Ascending Aortic Dilatation and Effacement in Elite Rugby Players. Heart Lung Circ. 2019 Jun 28. pii: S1443-9506(19)31323-X. doi: 10.1016/j.hlc.2019.06.714. [Epub ahead of print] PubMed PMID: 31494040.
  • Guley NM, Del Mar NA, Ragsdale T, Li C, Perry AM, Moore BM, Honig MG, Reiner A. Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189. Exp Eye Res. 2019 May;182:109-124. doi: 10.1016/j.exer.2019.03.013. Epub 2019 Mar 26. PubMed PMID: 30922891; PubMed Central PMCID: PMC6504571.
  • Moore BM, Chan KH, Sy RW. Catheter Ablation for Atrial Fibrillation in Heart Failure: Ready for Mainstream Adoption, or Is More Evidence Needed? Heart Lung Circ. 2019 May;28(5):665-666. doi: 10.1016/j.hlc.2019.02.006. Epub 2019 Feb 25. PubMed PMID: 30846417.
  • Pressly JD, Soni H, Jiang S, Wei J, Liu R, Moore BM, Adebiyi A, Park F. Activation of the cannabinoid receptor 2 increases renal perfusion. Physiol Genomics. 2019 Mar 1;51(3):90-96. doi: 10.1152/physiolgenomics.00001.2019. Epub 2019 Feb 1. PubMed PMID: 30707046; PubMed Central PMCID: PMC6459373.
  • Moore BM, Wang P, Fan P, Leong B, Schenck CA, Lloyd JP, Lehti-Shiu MD, Last RL, Pichersky E, Shiu SH. Robust predictions of specialized metabolism genes through machine learning. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2344-2353. doi: 10.1073/pnas.1817074116. Epub 2019 Jan 23. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5830. PubMed PMID: 30674669; PubMed Central PMCID: PMC6369796.

View more references (pubmed link)

Last Published: Dec 20, 2019