Jianxiong Jiang, PhD

Education

• PhD Institution: Auburn University, Auburn, AL
• Postdoctoral: Emory University, Atlanta, GA

Links

• Lab Website
  https://jiang.lab.uthsc.edu

  Google Scholar
  https://scholar.google.com/citations?user=9OunJogAAAAJ

Research Interests

The research in our laboratory aims to better understand the neuroinflammatory processes following acute excitotoxic insults such as status epilepticus and cerebral ischemia. More recently, we have begun to explore the neuron-glia interactions in malignant gliomas, the most devastating brain tumors that constitute a major cause for epilepsy, particularly in the elderly. We attempt to unlock the molecular mechanisms whereby normal brains are transformed to generate spontaneous seizures during the epileptogenesis of various etiologies. We are also interested in developing new pharmacotherapies for these inflammation-associated conditions in close collaboration with medicinal chemistry labs. To achieve these goals, we use a variety of technologies and experimental systems, such as high-throughput screening, chemical genetics, TR-FRET, RNAi, CRISPR/Cas9, microdialysis, time-locked video EEG, unbiased stereology, behavioral tests, etc. In so doing, we help to bridge the gap between the basic biomedical research discoveries and their translation into clinical innovations.

Representative Publications

• Yu Y, Nguyen DT, Jiang J. G protein-coupled receptors in acquired epilepsy: Druggability and translatability. Prog Neurobiol. 2019 Dec;183:101682. doi: 10.1016/j.pneurobio.2019.101682. Epub 2019 Aug 24. Review. PubMed PMID: 31454545.
• Dawn A, Yao X, Yu Y, Jiang J, Kumari H. Assessment of the in vitro toxicity of calixarenes and a metal-seamed calixarene: a chemical pathway for clinical application. Supramol Chem. 2019;31(7):425-431. doi: 10.1080/10610278.2019.1616732. Epub 2019 May 13. PubMed PMID: 31371909; PubMed Central PMCID: PMC6675036.
• Jiang J, Yu Y, Kinjo ER, Du Y, Nguyen HP, Dingledine R. Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury. Neuropharmacology. 2019 May 1;149:149-160. doi: 10.1016/j.neuropharm.2019.02.011. Epub 2019 Feb 11. PubMed PMID: 30763657; PubMed Central PMCID: PMC6486887.
• Qiu J, Li Q, Bell KA, Yao X, Du Y, Zhang E, Yu JJ, Yu Y, Shi Z, Jiang J. Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. Br J Pharmacol. 2019 Jun;176(11):1680-1699. doi: 10.1111/bph.14622. Epub 2019 Apr 29. PubMed PMID: 30761522; PubMed Central PMCID: PMC6514294.
• Jiang J, Van TM, Ganesh T, Dingledine R. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. doi: 10.1021/acschemneuro.7b00486. Epub 2018 Jan 4. PubMed PMID: 29292987; PubMed Central PMCID: PMC6318807.
• Hartings JA, York J, Carroll CP, Hinzman JM, Mahoney E, Krueger B, Winkler MKL, Major S, Horst V, Jahnke P, Woitzik J, Kola V, Du Y, Hagen M, Jiang J, Dreier JP. Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction. Brain. 2017 Oct 1;140(10):2673-2690. doi: 10.1093/brain/awx214. PubMed PMID: 28969382; PubMed Central PMCID: PMC5841026.

View more references (pubmed link)