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Kristin Hamre, PhD

Assistant Professor
Department of Anatomy and Neurobiology

The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: 901.448.2643
Fax: 901.448.7193
Lab: 220 Wittenborg Anatomy Building
Email: Kristin Hamre

Education

  • PhD Institution: Department of Anatomy, University of Iowa, Iowa City, IA
  • Postdoctoral: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN (laboratory of Dr. Daniel Goldowitz)

Research Interests

There are 2 major foci of my research, both centered on the interaction between genetics and the nervous system. The first major focus is centered on examining the relationship between genetics and several ethanol-related phenotypes in both the developing embryo and the adult animal. This research uses both strategies that attempt to identify the critical genes in mediating a phenotype as well as the opposite strategy of determining the role of a specific gene in a phenotype using mutant mice. Both behavioral and anatomic phenotypes (e.g. cell death markers) are examined. The second major focus is examining how specific genes impact the development of various neuronal populations. In this approach the effect of a mutated gene, either in naturally-occurring or induced mutations, on the morphology of a specific structure or cell type is examined.

Representative Publications

  • Théberge ET, Baker JA, Dubose C, Boyle JK, Balce K, Goldowitz D, Hamre KM. Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Midgestation. Alcohol Clin Exp Res. 2019 Mar;43(3):439-452. doi: 10.1111/acer.13947. Epub 2019 Feb 12. PubMed PMID: 30589433; PubMed Central PMCID: PMC6410727.
  • Zhou D, Zhao Y, Hook M, Zhao W, Starlard-Davenport A, Cook MN, Jones BC, Hamre KM, Lu L. Ethanol's Effect on Coq7 Expression in the Hippocampus of Mice. Front Genet. 2018 Dec 4;9:602. doi: 10.3389/fgene.2018.00602. eCollection 2018. PubMed PMID: 30564271; PubMed Central PMCID: PMC6288283.
  • Zhou DX, Zhao Y, Baker JA, Gu Q, Hamre KM, Yue J, Jones BC, Cook MN, Lu L. The effect of alcohol on the differential expression of cluster of differentiation 14 gene, associated pathways, and genetic network. PLoS One. 2017 Jun 2;12(6):e0178689. doi: 10.1371/journal.pone.0178689. eCollection 2017. PubMed PMID: 28575045; PubMed Central PMCID: PMC5456352.
  • Baker JA, Li J, Zhou D, Yang M, Cook MN, Jones BC, Mulligan MK, Hamre KM, Lu L. Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice. Alcohol. 2017 Feb;58:139-151. doi: 10.1016/j.alcohol.2016.08.008. Epub 2016 Dec 16. PubMed PMID: 28027852; PubMed Central PMCID: PMC5270764.
  • Duan C, Chen Y, Shen A, Xu J, Zhao Y, Cai R, Liu Y, Zhou L, Lei Y, Hamre K, Lu L. Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse. Gene. 2016 May 1;581(2):130-8. doi: 10.1016/j.gene.2016.01.032. Epub 2016 Jan 20. PubMed PMID: 26802973.
  • Urquhart KR, Zhao Y, Baker JA, Lu Y, Yan L, Cook MN, Jones BC, Hamre KM, Lu L. A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors. Neurogenetics. 2016 Apr;17(2):91-105. doi: 10.1007/s10048-015-0470-0. Epub 2016 Jan 18. PubMed PMID: 26780340.

View more references (pubmed link)

May 26, 2022