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Paula Dietrich, PhD

Assistant Professor
Department of Physiology

The University of Tennessee Health Science Center
894 Union Avenue
Memphis, TN 38163
Office: 901.448.3118
Fax: 901.448.7126
Email: Paula Dietrich

Education

  • PhD Institution: Department of Genetics and Development, Columbia University, New York, NY
  • Postdoctoral: Department of Neurology, Columbia University, New York, NY; Department of Physiology, The University of Tennessee, Memphis, TN

Research Interests

Analyses of mouse models of human neurodegenerative disorders, in particular models for Huntington's disease and Familial Dysautonomia. Analyses of the normal function of huntingtin in brain development and function.

Representative Publications

  • Morini E, Gao D, Montgomery CM, Salani M, Mazzasette C, Krussig TA, Swain B, Dietrich P, Narasimhan J, Gabbeta V, Dakka A, Hedrick J, Zhao X, Weetall M, Naryshkin NA, Wojtkiewicz GG, Ko CP, Talkowski ME, Dragatsis I, Slaugenhaupt SA. ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia. Am J Hum Genet. 2019 Apr 4;104(4):638-650. doi: 10.1016/j.ajhg.2019.02.009. Epub 2019 Mar 21. PubMed PMID: 30905397; PubMed Central PMCID: PMC6451698.
  • Shukla PK, Meena AS, Manda B, Gomes-Solecki M, Dietrich P, Dragatsis I, Rao R. Lactobacillus plantarum prevents and mitigates alcohol-induced disruption of colonic epithelial tight junctions, endotoxemia, and liver damage by an EGF receptor-dependent mechanism. FASEB J. 2018 Jun 18:fj201800351R. doi: 10.1096/fj.201800351R. [Epub ahead of print] PubMed PMID: 29912589; PubMed Central PMCID: PMC6181630.
  • Dietrich P, Johnson IM, Alli S, Dragatsis I. Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis. PLoS Genet. 2017 Jul 17;13(7):e1006846. doi: 10.1371/journal.pgen.1006846. eCollection 2017 Jul. PubMed PMID: 28715425; PubMed Central PMCID: PMC5536499.
  • Dietrich P, Dragatsis I. Familial Dysautonomia: Mechanisms and Models. Genet Mol Biol. 2016 Oct-Dec;39(4):497-514. doi: 10.1590/1678-4685-GMB-2015-0335. Epub 2016 Aug 4. PubMed PMID: 27561110; PubMed Central PMCID: PMC5127153.
  • Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I. Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia. Hum Mol Genet. 2016 Mar 15;25(6):1116-28. doi: 10.1093/hmg/ddv634. Epub 2016 Jan 13. PubMed PMID: 26769677; PubMed Central PMCID: PMC4764193.
  • Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochim Biophys Acta. 2016 Apr;1860(4):765-74. doi: 10.1016/j.bbagen.2015.12.013. Epub 2015 Dec 23. PubMed PMID: 26721332; PubMed Central PMCID: PMC4776745.

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Last Published: Apr 19, 2021