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Alternatives for Life Science Requirements

Students able to meet prerequisites for the courses below may be able to substitute appropriate credits from them for Life Sciences of Biomedical Engineers, parts I and II. Doctoral students who take the Life Sciences for Biomedical Engineers, parts I and II, during the MS-like portion of their curriculum can select further credits in life sciences from this list.

IP 803 Essentials of Biochemistry and Molecular Biology. The course integrates the fundamental aspects of biochemistry and molecular biology. Topics covered include: biochemical and biophysical principles (bonding, properties of water, thermodynamics, ionization and acid-base theory, and chemical kinetics); structure, synthesis, and function of proteins; nucleic acid metabolism; DNA and chromosome structure and replication; transcription and gene regulation in prokaryotes and eukaryotes; biomembranes; intracellular organelles and membrane trafficking; and mitochondria and bioenergetics. Credit 6 (6-0).

IP 842 Systems Biology. The course is intended to aid the beginning graduate student to develop an understanding of 1) how each of the major organ systems functions and contributes to the body’s ability to maintain its internal environment in the face of both internal and external disturbances, 2) how the body protects itself from invading pathogens, 3) how drugs affect various processes to produce alterations in cellular or organ system function, and 4) the basic causes of the major types of diseases. Credit 10.

IP 843 Cellular and Molecular Biology. The course integrates the fundamental aspects of biochemistry, cell biology, and molecular biology. Topics covered include biochemical and biophysical principles (bonding, properties of water, thermodynamics, ionization and acid-base theory, and chemical kinetics); structure, synthesis, and function of proteins; nucleic acid metabolism; DNA and chromosome structure and replication; transcription and gene regulation in prokaryotes and eukaryotes; biomembranes; intracellular organelles and membrane trafficking; mitochondria and bioenergetics; cell signaling; cytoskeletal structure and function; cell cycle and cell growth; cell differentiation; extracellular matrix and cell adhesion; and genetics of human disease. Credit 8 (8-0).

IP 940 Molecular Biology of Cancer. The course will provide a comprehensive survey of cancer biology, describing the disrupted normal development processes, the altered molecular mechanisms that govern the functioning of malignant cells, the biology and treatments of common types of cancer, and the development of therapies for treatment of resistant and metastatic cancer cells. Credit 4 (4-0).

ANAT 823 Cellular Neuroscience. This course provides the student with an overview of the cellular and molecular processes by which nerve cells communicate. The course covers classical theories and concepts as a basis for appreciation of recent research advances. Lectures by the faculty will provide core material to guide students in presentation of current research topics in Neurochemistry, Neuropharmacology, and Neurophysiology. Extensive reading of the literature will supplement lectures and presentations. Prerequisite: Morphological Neuroscience (822 ANAT) or equivalent. Spring. Credit 3 (3-0).

ANAT 824 Techniques in Neuroscience. This course will train the student in the use of standard and state-of-the-art research techniques in neuroanatomy, neurophysiology, and neurochemistry. Instruction will be by faculty actively employing these techniques in their own research and who, in several cases, have contributed to the innovation and improvement of a method. It is intended to provide practical experience in the major techniques of neuroscience. This course is intended to (1) acquaint the student with the theoretical basis of each technique, (2) teach the student the laboratory skills necessary to perform each technique, (3) teach the student how to critically evaluate the results and to be aware of the pitfalls of each technique, and (4) acquaint the student with the possible combinations of any single technique with others in designing experiments. Prerequisite: Permission of the instructor. Spring (second half). Credit 3.

ANAT 922 General Cell Biology. A lecture course covering current areas of research in cell biology with particular emphasis on correlation of the ultrastructure of cellular components with their physiological and biochemical function. Prerequisites: Microscopic anatomy and general biochemistry or equivalent. Credit and hours by arrangement.

MSCI 812 Physical Biochemistry and Applications in Structural Biology. A lecture course in physical biochemistry that is divided into two parts. The first part covers the major experimental techniques used in physical biochemistry, including X-ray crystallography, NMR spectroscopy, general spectroscopy, and thermodynamics. The theoretical and experimental bases of the techniques will be emphasized. The second part addresses the structure and mechanisms of biological macromolecules, and many of the major classes of proteins will be discussed, as well as the structures of DNA and RNA. Emphasis will be on the physicochemical processes that control the folding and stability of macromolecules and on the processes that determine their unique structures and functions. The course will be accompanied by problem sets and practical sessions in the laboratory, and students will also be provided with software for viewing and manipulating structures on personal computers. Prerequisites: calculus, physics, biology, organic chemistry, biochemistry, physical chemistry, and 811 MSCI or permission of the course director. Offered in alternate years. Credit: 3 (3-0).

MSCI 813 Immunology. A comprehensive survey course of both cellular and molecular immunology. The course analyzes the detailed mechanisms that control rearrangements and expression of genes that encode immune receptors, cell-cell communications among cells that are involved in immune responses, antigen-antibody interactions, and other topics in serology and host immune responses. Offered in alternate years. Credit 3 (30).

MSCI 814 Bioinformatics I. This course consists of eleven 2.5-hour segments. The material will be introduced in a brief lecture format for 30-45 minutes as necessary. The majority of time will be spent using computer applications of bioinformatics tools. The course is designed to provide practical training in bioinformatics methods including accessing the major public sequence databases, using the five BLAST tools to find sequences, analyzing protein and nucleic acid sequences by various software packages like Vector NTI or SeqWeb, detecting motifs or domains in proteins, assembling protein sequences from genomic DNA, detecting exons and finding intron-exon boundaries, aligning sequences (Clustal W), making phylogenetic trees (Phylip), and comparative genomics. Students should leave the course with a working knowledge of how to carry out research using these tools. Prerequisite: general knowledge of gene and protein structure. Credit 2 (1-2).

MSCI 815 Bioinformatics II. This course consists of six 2.5-hour segments partially as lecture and partially as computer tutorial sessions to demonstrate advanced bioinformatics methods and the use of databases. The course follows Bioinformatics I. Topics include finding and using public databases other than NCBI; private databases and understanding the politics of genomics; genome browsers and NCBI’s genomic biology section; gene arrays-their construction, use, and data analysis; mapping quantitative trait loci (QTLs) and radiation hybrid mapping; and 3D protein structure viewers and threading. Prerequisites: Bioinformatics I or permission of the instructor. Credit 1 (0-2).

MSCI 861 Cellular Signaling. The course will provide a comprehensive survey of cellular signaling, describing, mechanisms of signal transduction. The lectures will detail cellular signaling from the major classes of cell surface receptors to the impact on nuclear events. The class will emphasize the integration and coordination of signaling pathways in the cell and how this impacts on the fact of the cell. Prerequisites: IP 842 and IP 843 or permission of course directors. Credit: 3 (3-0).

MSCI 911 Applied Proteomics. The goal of this course will be to systematically evaluate the use of proteomics in defined experimental situations. In the first part of the course this will be accomplished by requiring students to read and present relevant articles from the proteomic literature to learn the strengths and weaknesses of different proteomic approaches. Subsequently, direct perspective of the practicality/efficiency of these approaches will be gained by applying proteomics to research projects of each student followed by class presentation, discussion, and analysis of real proteomics data and results. These research projects may be actual components of the graduate research project, or hypothetical, correct application of current methods relevant to the students’ graduate work or special interest. Credit: 2.

MSCI 926 Proteins and Enzymes. A course on structure of proteins and enzyme catalysis as well as regulation. Prerequisite: 811 MSCI. Offered in alternate years. Credit 3 (3-0).

MSCI 930 Molecular and Cellular Basis of Pathogenesis. The course will provide a comprehensive overview of both viral and bacterial pathogenesis from the perspective of both host and pathogen. The lectures are intended to complement the immunology and pathophysiology lectures in IP 842 “Systems Biologyâ€? to provide a comprehensive and fundamental understanding of the concepts that govern host-pathogen interactions. Lectures will present in detail the molecular genetic, structural, and cellular mechanisms that viral and bacterial pathogens use to infect cells and tissues of the host and the subsequent disease consequences of infection. Prerequisite: IP842 Systems Biology and IP843 Cellular and Molecular Biology or permission of the course director. Credit 3 (3-0). *Required of all Molecular Sciences graduate students.

PATH 826 Cell Biology. A course in cell biology that requires 811 BIOC as a prerequisite. The course covers introduction to the cell, cell motility/cell migration, cell cycle regulation/multiplication, nucleus/gene expression, membrane maintenance of cellular compartments, and extracellular matrix. Spring. Credit 4 (4 0).

CMED 711 Essentials of Animal Experimentation. This course is designed to provide an overview of appropriate and effective use of animals in biomedical research. Topics to be covered include regulatory requirements, biomethodology, principles of experimental animal surgery, postoperative veterinary care, and animal care and use procedures. Emphasis is placed on practical experience with living animals and practice of techniques under anesthesia. No text is required. Scheduling of lecture and laboratory will be done following registration to accommodate other courses and time obligations. Fall. Credit 2 (2-1).

CMED 712 Biology and Pathophysiology of Laboratory Animals I. This course expands on much of the material covered in 711 CMED. Emphasis will be placed on the following species: mice, rats, guinea pigs, rabbits, and hamsters. Subjects to be covered include the taxonomy, applied anatomy and physiology, pharmacology, genetics, immunology, nutrition, behavior, husbandry, use as an animal model, and in-depth pathophysiology of significant diseases of each species. Laboratory procedures available for diagnosing these diseases will be discussed, including their limitations and how adventitious pathogens disrupt and confound experimental results derived from infected animals. Emphasis will be placed on features that make a particular species uniquely suitable for certain types of research. Prerequisite: 711 COMED or permission of instructor. Spring, alternate years. Credit 2 (2-0).

PHAC 911 Delivery and Biocompatibility of Protein and Nucleic Acid Drugs. This course is designed to teach students about the use of biomaterials for delivery and biocompatibility of proteins, peptides, and various nucleic acid drugs. It will cover (1) design, synthesis, and characterization of polymers; (2) biocompatibility; (3) various approaches to proteins and peptide delivery; (4) introduction to different types of nucleic acid drugs; and (5) antisense and nonviral gene therapy. Prerequisites: 1 year of organic, medicinal, or physical chemistry (or equivalent) or B.S. in Pharmacy, Bioengineering, Biotechnology, Biochemistry, Pharmacology, or Medical Sciences (or equivalent) or permission of the instructor. A basic understanding of cell and molecular biology is desirable but is not required. Credit 3 (3-0).

6071. Human Genetics. (3). Genetic principles as they apply to humans, including pedigree analysis, genetic counseling, cancer, and genomics. PREREQUISITE: BIOL 3072.

6350. Microbial Biotechnology. (3). Principles underlying practical applications of microorganisms, including synthesis of commercial products, vaccines and antibodies, bioremediation and biomass utilization, plant biotechnology, and food production. PREREQUISITES: BIOL 3550 and CHEM 3312.

6380. Histology: Tissue and Organ Biology (4). Histology, with emphasis on the relationship between structure and function in mammalian tissues and organs; human histology emphasized. Three lecture, three laboratory hours per week. PREREQUISITE: BIOL 1120 and 1121.

6445. Immunology. (3). (BIOL 6444). Antigens, immunoglobulin classes, cells and cytokines of immune response, complement system, hypersensitivities, blood groups, vaccines, and immunity. PREREQUISITES: BIOL 3130 or 3500 and CHEM 1120.

6470. Molecular Genetics. (4). Structure, function, and replication of DNA, recombination, colinearity of DNA with genetic map, mutagenesis, plasmids, genetic code, protein synthesis, suppression, regulation of gene expression, genetic engineering, and immunogenetics. For students without formal training in molecular genetics. Four lecture hours per week. PREREQUISITES: BIOL 3072 and BIOL 3130 or 3500.

6480. Cellular and Molecular Pharmacology. (3). Provides basic understanding of mechanisms by which therapeutic agents regulate physiological function of cells comprising organ systems such as the heart and central nervous system; drug action (pharmacodynamics) addressed at the molecular, cellular, and organ level, as well as common diseases affecting a system. PREREQUISITES: CHEM 1120 and BIOL 3130.

6511. Biochemistry I. (3). (Same as CHEM 6511). Chemistry of amino acids and proteins related to their properties in biochemical systems; enzymology, including kinetics and conformation studies; coenzymes and their functions; importance of pH; bioenergetics; chemistry of carbohydrates, lipids, and nucleotides. PREREQUISITE: CHEM 3312.

6512. Biochemistry II. (3). (Same as CHEM 6512). Metabolism of carbohydrates, amino acids, and nucleotides, with emphasis on mammalian systems; biochemistry of RNA and DNA, including their relationship to biosynthesis of proteins, DNA and RNA. PREREQUISITE: BIOL 6511 or CHEM 6511.

7031-8031. Cellular Physiology. (3). Cellular thermodynamics, membrane transport systems, ion channels, oxidative phosphorylation, electron transport, cytoskeleton and mechanochemical coupling systems. Three lecture hours per week.

7040-8040. Light Microscopy and Image Processing. (3). Light microscope optics, theory and practice of confocal microscopy, current techniques in fluorescence microscopy, digital image acquisition and processing. Lectures occasionally supplemented with demonstrations.

7051-8051. Vertebrate Cell Culture. (3) Theory, principles, and protocols in use of vertrebrate cell cultures and cell lines in biomedical research.

7131-8131. Cell and Molecular Biology. (4). Introduction to principles of molecular biology as they apply to eukaryotic cells including transcription, translation, regulation of protein function, DNA replication, membrane biogenesis, secretion, hormone action, signal transduction, and ligand receptor interaction. Four lecture hours per week.

7135-8135. Protein Trafficking. (3). Modern theories of co-translational and post-translational protein targeting in eukaryotic cells to include function and evolution of classical trafficking pathway elements. PREREQUISITES: BIOL 3130 and BIOL 4512-6512.

7140-8140. Receptors and Signaling. (3). Develops state-of-the-art understanding of issues in cell receptors and signaling, covering receptor-ligand interactions including methods of identification and quantification; emphasizes specific characteristics of G protein-coupled receptors, receptor tyrosine kinases, and ligand-activate transcription factors including mechanisms of action and signaling pathways activated by each receptor.

7290-8290. Molecular Computing. (3). (Same as COMP 7290-8290). Basics of cell biology and genetics (DNA structure and enzymes, replication, and translation); feasible DNA-based solution of hard computational problems; issues in the design of molecular computers; foundations of nanotechnology. PREREQUISITE: COMP 6030 or permission of instructor.

7440-8440. Molecular Biology of Cancer. (3). Introduction to molecular basis of cancer, cancer therapy and prevention; includes disease-, chemical carcinogen-, and viral-based views of cancer process; surveys modern tools for identifying cancer susceptibility genes and classifying tumors. PREREQUISITES: BIOL 4503-6503 or BIOL 4470-6470, or permission of instructor.

7464-8464. Advanced Immunology. (4). Selected topics and laboratories in molecular and cellular immunology, immunobiology, tumor immunology, and medical aspects of immunology. Three lecture, two laboratory hours per week. PREREQUISITES: BIOL 6445 and 6511 or their equivalent.

May 26, 2022