Paula Dietrich, Ph.D.

Photo of Paula Dietrich, Ph.D.

Assistant Professor
Department of Physiology


The University of Tennessee Health Science Center
894 Union Avenue
Memphis, TN 38163
Office: (901) 448-3118
Fax: (901) 448-7126
Email: Paula Dietrich



Education

  • Ph.D. Institution: Department of Genetics and Development, Columbia University, New York, NY
  • Postdoctoral: Department of Neurology, Columbia University, New York, NY; Department of Physiology, The University of Tennessee, Memphis, TN

Research Interests

Analyses of mouse models of human neurodegenerative disorders, in particular models for Huntington's disease and Familial Dysautonomia. Analyses of the normal function of huntingtin in brain development and function.

Representative Publications

  • Dietrich P, Alli S, Shanmugasundaram R, Dragatsis I. IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia. Hum Mol Genet. 2012 Dec 1;21(23):5078-90. doi: 10.1093/hmg/dds354. Epub 2012 Aug 24. PubMed PMID: 22922231; PubMed Central PMCID: PMC3490515.
  • Dietrich P, Yue J, E S, Dragatsis I. Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality. PLoS One. 2011;6(10):e27015. doi: 10.1371/journal.pone.0027015. Epub 2011 Oct 28. PubMed PMID: 22046433; PubMed Central PMCID: PMC3203942.
  • Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest. 2011 Nov;121(11):4372-82. doi: 10.1172/JCI57552. Epub 2011 Oct 10. PubMed PMID: 21985783; PubMed Central PMCID: PMC3223861.
  • Reiner A, Dragatsis I, Dietrich P. Genetics and neuropathology of Huntington's disease. Int Rev Neurobiol. 2011;98:325-72. doi: 10.1016/B978-0-12-381328-2.00014-6. Review. PubMed PMID: 21907094.
  • Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron. 2010 Aug 12;67(3):392-406. doi: 10.1016/j.neuron.2010.06.027. PubMed PMID: 20696378.
  • Dietrich P, Shanmugasundaram R, Shuyu E, Dragatsis I. Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum Mol Genet. 2009 Jan 1;18(1):142-50. doi: 10.1093/hmg/ddn324. Epub 2008 Oct 6. PubMed PMID: 18838463; PubMed Central PMCID: PMC3298867.

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