Jonathan H. Jaggar, Ph.D.
Maury Bronstein Professor
Department of Physiology
The University of Tennessee Health Science Center
894 Union Avenue
Memphis, TN 38163
Phone: (901) 448-1208
Office: 402 Nash Research Building
Email: Jonathan H. Jaggar
- Ph.D. Institution: University of Sheffield, United Kingdom
Arterial diameter, a primary determinant of systemic blood pressure, is regulated by the contractile state of smooth muscle cells in the arterial wall. One critical regulator of smooth muscle contractility is the intracellular calcium ion concentration. Smooth muscle cells control intracellular calcium concentration by regulating cellular influx, release, sequestration and extrusion. Since membrane potential regulates calcium entry in smooth muscle cells, ion channels that modulate membrane potential also change cellular contractility. Recent studies have discovered that local and global elevations in cytosolic calcium occur in smooth muscle cells. These different calcium signaling events not only regulate contractility, but may also regulate a number of other physiological functions. We are currently investigating sarcolemma ion channels that control membrane potential and calcium entry in arterial smooth muscle cells and the properties, physiological targets, and regulation of arterial diameter by different intracellullar calcium signals. Research in the laboratory involves a multi-faceted approach, studying events at molecular, cellular and intact artery levels. Techniques include patch clamp electrophysiology, rapid confocal calcium imaging, conventional calcium imaging, diameter measurement of pressurized arteries, and molecular biology.
- Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH. Dynamic regulation of Î²1 subunit trafficking controls vascular contractility. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2361-6. doi: 10.1073/pnas.1317527111. Epub 2014 Jan 24. PubMed PMID: 24464482; PubMed Central PMCID: PMC3926029.
- Bulley S, Jaggar JH. Cl(-) channels in smooth muscle cells. Pflugers Arch. 2013 Sep 28. [Epub ahead of print] PubMed PMID: 24077695.
- Narayanan D, Bulley S, Leo MD, Burris SK, Gabrick KS, Boop FA, Jaggar JH. Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries. J Physiol. 2013 Oct 15;591(Pt 20):5031-46. doi: 10.1113/jphysiol.2013.258319. Epub 2013 Jul 15. PubMed PMID: 23858011; PubMed Central PMCID: PMC3810807.
- Bannister JP, Leo MD, Narayanan D, Jangsangthong W, Nair A, Evanson KW, Pachuau J, Gabrick KS, Boop FA, Jaggar JH. The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator. J Physiol. 2013 Jun 15;591(Pt 12):2987-98. doi: 10.1113/jphysiol.2013.251926. Epub 2013 Apr 8. PubMed PMID: 23568894; PubMed Central PMCID: PMC3832115.
- Schwingshackl A, Teng B, Ghosh M, Lim KG, Tigyi G, Narayanan D, Jaggar JH, Waters CM. Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L276-86. doi: 10.1152/ajplung.00299.2012. Epub 2012 Dec 28. PubMed PMID: 23275623; PubMed Central PMCID: PMC3567358.
- Adebiyi A, Thomas-Gatewood CM, Leo MD, Kidd MW, Neeb ZP, Jaggar JH. An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension. 2012 Nov;60(5):1213-9. doi: 10.1161/HYPERTENSIONAHA.112.198820. Epub 2012 Oct 8. PubMed PMID: 23045459; PubMed Central PMCID: PMC3632264.