Fu-Ming Zhou, Ph.D.

Fu-Ming Zhou, Ph.D.

Associate Professor
Department of Pharmacology


The University of Tennessee Health Science Center
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-1779
Lab: 315 Crowe Building
Email: Fu-Ming Zhou



Education

  • Ph.D. Institution: Department of Physiology and Biophysics, University of Alabama at Birmingham
  • Postdoctoral: Department of Neurobiology, University of Alabama at Birmingham

Link

Pharmacology - Fu-Ming Zhou

Research Interests

Dr. Zhou currently conducts a multidisciplinary research program designed to determine the molecular, cellular and neuropharmacological mechanisms of the brain monoamine systems. Particular attention is being paid to the contributions of these monoamine systems to neuropsychiatric disorders such as Parkinsonās disease, depression, schizophrenia, drug abuse, and attention deficit hyperactivity disorder (ADHD). We use rodents as our experimental animals. Mutant mice are used in specific cases.

Several techniques are used in the laboratory:

  1. Electrophysiology-patch clamp
  2. Molecular biology (single cell RT-PCR in combination with patch clamp; gene expression profiling and manipulation)
  3. Electrochemistry (fast cyclic voltammetry at the carbon fiber microelectrode; HPLC)
  4. Immunohistochemistry (double and triple immunolabeling, confocal microscopy)

Funding

Dr. Zhou's research is funded by R01 grants from the National Institute on Drug Abuse and National Institute of Mental Health and grants from private foundations.

brain illustration

Representative Publications

  • Ding S, Li L, Zhou FM. Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection. J Neurosci. 2013 Mar 13;33(11):4875-85. doi: 10.1523/JNEUROSCI.4111-12.2013. PubMed PMID: 23486958; PubMed Central PMCID: PMC3617555.
  • Li L, Zhou FM. Parallel dopamine D1 receptor activity dependence of l-Dopa-induced normal movement and dyskinesia in mice. Neuroscience. 2013 Apr 16;236:66-76. doi: 10.1016/j.neuroscience.2012.12.065. Epub 2013 Jan 26. PubMed PMID: 23357114; PubMed Central PMCID: PMC3616626.
  • Li L, Qiu G, Ding S, Zhou FM. Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain Res. 2013 Jan 23;1491:236-50. doi: 10.1016/j.brainres.2012.11.010. Epub 2012 Nov 15. PubMed PMID: 23159831; PubMed Central PMCID: PMC3596263.
  • Dong HW, Davis JC, Ding S, Nai Q, Zhou FM, Ennis M. Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb. Neurosci Lett. 2012 Aug 22;524(1):49-54. doi: 10.1016/j.neulet.2012.07.013. Epub 2012 Jul 20. PubMed PMID: 22820212.
  • Ding S, Zhou FM. Profiling voltage-gated potassium channel mRNA expression in nigral neurons using single-cell RT-PCR techniques. J Vis Exp. 2011 Sep 27;(55). doi:pii: 3136. 10.3791/3136. PubMed PMID: 21989393.
  • Ding S, Wei W, Zhou FM. Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra. J Neurophysiol. 2011 Dec;106(6):3019-34. doi: 10.1152/jn.00305.2011. Epub 2011 Aug 31. PubMed PMID: 21880943; PubMed Central PMCID: PMC3234097.

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