Fu-Ming Zhou, Ph.D.

Fu-Ming Zhou, Ph.D.

Professor
Department of Pharmacology


The University of Tennessee Health Science Center
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-1779
Lab: 315 Crowe Building
Email: Fu-Ming Zhou

 

Education

  • Ph.D. Institution: Department of Physiology and Biophysics, University of Alabama at Birmingham
  • Postdoctoral: Department of Neurobiology, University of Alabama at Birmingham

Link

Pharmacology - Fu-Ming Zhou

Research Interests

Dr. Zhou currently conducts a multidisciplinary research program designed to determine the molecular, cellular and neuropharmacological mechanisms of the brain monoamine systems. Particular attention is being paid to the contributions of these monoamine systems to neuropsychiatric disorders such as Parkinson's disease, depression, schizophrenia, drug abuse, and attention deficit hyperactivity disorder (ADHD). We use rodents as our experimental animals. Mutant mice are used in specific cases.

Several techniques are used in the laboratory:

  1. Electrophysiology-patch clamp
  2. Molecular biology (single cell RT-PCR in combination with patch clamp; gene expression profiling and manipulation)
  3. Electrochemistry (fast cyclic voltammetry at the carbon fiber microelectrode; HPLC)
  4. Immunohistochemistry (double and triple immunolabeling, confocal microscopy)

Funding

Dr. Zhou's research is funded by R01 grants from the National Institute on Drug Abuse and National Institute of Mental Health and grants from private foundations.

Zhou BG Brain

Representative Publications

  • Sagot B, Li L, Zhou FM. Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice. Front Neural Circuits. 2018 Jul 30;12:57. doi: 10.3389/fncir.2018.00057. eCollection 2018. PubMed PMID: 30104963; PubMed Central PMCID: PMC6077202.
  • Zhou FM, Huang YY, Tian T, Li XY, Tang YB. Knockdown of Chloride Channel-3 Inhibits Breast Cancer Growth In Vitro and In Vivo. J Breast Cancer. 2018 Jun;21(2):103-111. doi: 10.4048/jbc.2018.21.2.103. Epub 2018 Jun 20. PubMed PMID: 29963105; PubMed Central PMCID: PMC6015970.
  • Du Y, Tu YS, Tang YB, Huang YY, Zhou FM, Tian T, Li XY. Requirement of ClC-3 in G0/G1 to S Phase Transition Induced by IGF-1 via ERK1/2-Cyclins Cascade in Multiple Myeloma Cells. Clin Lab. 2018 Jun 1;64(6):929-936. doi: 10.7754/Clin.Lab.2018.171205. PubMed PMID: 29945325.
  • Bouabid S, Zhou FM. Cyclic AMP-producing chemogenetic activation of indirect pathway striatal projection neurons and the downstream effects on the globus pallidus and subthalamic nucleus in freely moving mice. J Neurochem. 2018 Jun;145(6):436-448. doi: 10.1111/jnc.14331. Epub 2018 Apr 22. PubMed PMID: 29500819; PubMed Central PMCID: PMC6030436.
  • Guo R, Zhou FM, Su CJ, Liu TT, Zhou Y, Fan L, Wang ZH, Liu X, Huang Y, Liu T, Yang J, Chen LH. Epigallocatechin-3-gallate attenuates acute and chronic psoriatic itch in mice: Involvement of antioxidant, anti-inflammatory effects and suppression of ERK and Akt signaling pathways. Biochem Biophys Res Commun. 2018 Feb 19;496(4):1062-1068. doi: 10.1016/j.bbrc.2018.01.122. Epub 2018 Feb 1. PubMed PMID: 29402411.
  • Wang Y, Zhou FM. Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation. Front Pharmacol. 2017 Dec 21;8:935. doi: 10.3389/fphar.2017.00935. eCollection 2017. PubMed PMID: 29311936; PubMed Central PMCID: PMC5742616.

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