Polly Hofmann, Ph.D.


phofmann

Professor
Sr. Executive Associate Dean of Faculty Affairs
910 Madison Suite 1006
Memphis TN 38163

Phone: 901-448-2464
Fax: 901-448-7683
Email: phofmann@uthsc.edu

Education

1982 B.S. University of Illinois, Champaign, IL
1987 Ph.D., University of Pittsburgh, School of Medicine
1987 - 1991 Postdoctoral Fellow, University of Wisconsin, Madison, Department of Physiology

Research Interests

Dr. Hofmann joined UTHSC in 1991.  Her NIH-funded research focused on short and long-term modification of various myocardial proteins through phosphorylation and their impact on cardiac survival following ischemia and myocardial function of the hypertrophied heart.  The main body of her work was on the molecular mechanisms by which ser/thr phosphatases, such as PP1 and PP2a, are modified/regulated and the role of phosphatases in altering myocardial function and survival. 

In 2008 Dr Hofmann became the Associate Dean of Faculty Affairs in the College of Medicine.  This was followed by a series of leadership roles and duties including Special Assistant to the Chancellor, Principle Investigator for a ~$3 million grant for interdisciplinary simulation in health care training awarded by Blue Cross Blue Shield of TN, Sr Associate Vice Chancellor of Research, and Interim Chair of multiple departments in the College of Medicine.  Currently, she is a Professor and Senior Executive Associate Dean of Faculty Affairs in the College of Medicine.

hoffmann-interest-diagram

 

Representative Publications

  • Deshmukh, P.D., B.C. Blunt and P.A. Hofmann. Acute modulation of PP2a and troponin I phosphorylation in ventricular myocytes: studies with a novel PP2a peptide inhibitor. American Journal of Physiology, 292(2):H792-9, 2007.
  • Zhu, Z., P. Hofmann and J.K. Buolamwini.  Cardioprotective effects of novel tetrahydroisoquinoline analogues of nitrobenzymercaptopurine riboside in perfuse isolated hearts. American Journal of Physiology, 292(6):H2921-6, 2007.
  • Blunt, B.C., Creek A.T., Henderson D.C., and P.A. Hofmann. H2O2 activation of HSP25/27 protects desmin from calpain proteolysis in rat ventricular myocytes. American Journal of Physiology, 293(3):H1518-25, 2007.
  • Morrison, R.R., X. Tan, C. Ledent, S.J Mustafa and P.A. Hofmann.  Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning. American Journal of Physiology, 293(4):H2523-9, 2007.
  • Hofmann, P.A., M. Israel, Y. Koseki, J.J. Jenkins, M. Arsura, A. Janik, T.W. Sweatman, and L. Lothstein.  N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC activation.  Journal of Pharmacology and Experimental Therapeutics, 323(2):658-64, 2007.
  • Leary P.J., Rajasekaran S., Morrison R.R., Tuomanen E.I., Chin T.K., and P.A. Hofmann. A cardioprotective role for platelet activating factor through NOS dependent S-nitrosylation. Am J Physiol Heart Circ Physiol.  294(6):H2775-84, 2008.
  • Cai C, Lothstein L, Morrison RR, Hofmann PA. Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline n-benzyladriamycin-14-valerate (AD 198). J Pharmacol Exp Ther. 2010 Oct;335(1):223-30 .
  • Russell CK, Shreve R, Hofmann PA, Scarbecz M, Scheid C, Brescia W, Schwab C, Robinson MM. Assessing Teaching Activities on an Academic Health Science Center Campus.  Transformative Dialogues: Teaching & Learning Journal, 2010 3(3): 1-10.
  • Reichelt ME, Ashton KJ, Tan XL, Mustafa SJ, Ledent C, Delbridge LM, Hofmann PA, Headrick JP, Morrison RR.The adenosine A(2A) receptor - Myocardial protectant and coronary target in endotoxemia Int J Cardiol. 2013 Jul 1;166(3):672-80.
  • Ashton KJ, Reichelt ME, Mustafa SJ, Teng B, Ledent C, Delbridge LM, Hofmann PA, Morrison RR, Headrick JP. Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. Purinergic Signal. 2016 Sep 30. [Epub ahead of print]

Additional Information