The CPPT is dedicated to the development of optimal drug therapies in neonates, infants and children. Nearly 80% of medications marketed in the United States today carry no recommendations for use in children. The lack of pediatric labeling has resulted in our children being described as “therapeutic orphans.” The development of new drugs in the last three decades has revolutionized the therapeutic armamentarium of present day clinicians. Almost in parallel with the substantive benefits of many potent new drugs has been a balancing the increment of risk. The need to evaluate the risk-reward equation has given rise to new biomedical research directives in pediatric clinical trial design, developmental pharmacology, pharmacokinetics, pharmacodynamics, pharmacogenetics, quantitative drug analysis in biologic fluids, and mathematical modeling, interfaced with clinical medicine. More recently, the CPPT has expanded its academic focus to include research and education in the emerging areas of genomics, and, more specifically, pharmacogenomics.
The scope of the programs of the CPPT reflects both an extension of ongoing independent research efforts, as well as new initiatives, which would be impossible without the resources provided through the Center. The CPPT is unique in that it combines the expertise of clinical and basic pharmaceutical scientists, and academic pharmacists and physicians. This is accomplished through a partnership among the Colleges of Pharmacy and Medicine: the Departments of Clinical Pharmacy, Pharmaceutical Sciences, Hematology/Oncology, Molecular Pharmacology, and Pediatrics; and the institutions of St. Jude Children’s Research Hospital, Le Bonheur Children’s Medical Center and the University of Tennessee Health Science Center.
The Center for Pediatric Pharmacokinetics and Therapeutics is an accomplished research and education program made possible by the State of Tennessee. The CPPT is dedicated to the improvement of our children’s health by development of optimal drug therapies. Through research, education, and patient care, the CPPT continues to bring national and international prominence to the University of Tennessee Health Science Center, its Colleges of Pharmacy and Medicine, and our partner institutions, St. Jude Children’s Research Hospital and Methodist/Le Bonheur Health Systems. CPPT faculty directly care for our children making the Center unique among Center of Excellence programs around the State.