Lu Lu, M.D.

Lu Lu, M.D.

Professor
Department of Anatomy and Neurobiology


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-7557
Fax: (901) 448-1716
Lab: 521 Johnson Building
Email: Lu Lu



Education

  • M.D. Institution: Nantong Medical College, Nantong, China
  • Postdoctoral: Columbia University, New York, NY; University of Tennessee, Memphis, TN

Research Interests

I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. RI mice are an excellent resource for these studies and allow us to examine multiple types of data in a reference population. In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. In combination with the previously developed BXD strains this is the largest RI strain set in existence.

Many problems can be efficiently addressed using RI mice. One of these questions is the mechanism of genetic control over brain architecture. In order to study this issue we have collected extensive neuroanatomical and gene expression data in the brains of BXD strains. Because all animals are isogenic, we can collect data of the same and differing types from multiple animals and meaningfully relate each data set. This allows us to determine, for instance, whether steady state expression of a gene is related to an observed phenotype, for instance an aspect of brain architecture or a behavioral difference between strains.

Another fascinating problem that we are able to address with RI lines is the modulation of transcriptional control in response to environmental influences. Using the LXS and BXD RI strains we are examining the modulation of transcriptional control in response to alcohol, stress, and the combination of alcohol and stress treatments. By examining modulatory changes in response to these conditions, we hope to gain insight into the molecular substrates underlying differences in ethanol and stress responses?a question thought to be very important in understanding human alcoholism.

Representative Publications

  • Varedi M, Lu L, Howell CR, Partin RE, Hudson MM, Pui CH, Krull KR, Robison LL, Ness KK, McKenna RF. Peripheral Neuropathy, Sensory Processing, and Balance in Survivors of Acute Lymphoblastic Leukemia. J Clin Oncol. 2018 May 29:JCO2017767871. doi: 10.1200/JCO.2017.76.7871. [Epub ahead of print] PubMed PMID: 29812998.
  • Fernandez-Pineda I, Davidoff AM, Lu L, Rao BN, Wilson CL, Srivastava DK, Klosky JL, Metzger ML, Krasin MJ, Ness KK, Pui CH, Robison LL, Hudson MM, Sklar CA, Green DM, Chemaitilly W. Impact of ovarian transposition before pelvic irradiation on ovarian function among long-term survivors of childhood Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study. Pediatr Blood Cancer. 2018 May 11:e27232. doi: 10.1002/pbc.27232. [Epub ahead of print] PubMed PMID: 29750388.
  • Luo J, Xu P, Cao P, Wan H, Lv X, Xu S, Wang G, Cook MN, Jones BC, Lu L, Wang X. Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses. Front Mol Neurosci. 2018 Apr 5;11:102. doi: 10.3389/fnmol.2018.00102. eCollection 2018. PubMed PMID: 29674951; PubMed Central PMCID: PMC5895640.
  • Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, Bartolomei MS, De Plaen IG, Wang P, Yu J, Qian J, Tan XD. In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. Gastroenterology. 2018 Jul;155(1):144-155. doi: 10.1053/j.gastro.2018.03.058. Epub 2018 Apr 3. PubMed PMID: 29621481.
  • Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J. Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway. Biochem Biophys Res Commun. 2018 Apr 6;498(3):573-578. doi: 10.1016/j.bbrc.2018.03.021. Epub 2018 Mar 6. PubMed PMID: 29522718; PubMed Central PMCID: PMC5920696.
  • Delprato A, Bonheur B, Algéo MP, Murillo A, Dhawan E, Lu L, Williams RW, Crusio WE. A quantitative trait locus on chromosome 1 modulates intermale aggression in mice. Genes Brain Behav. 2018 Feb 19:e12469. doi: 10.1111/gbb.12469. [Epub ahead of print] PubMed PMID: 29457871.

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