Lu Lu, M.D.

Lu Lu, M.D.

Professor
Department of Anatomy and Neurobiology


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-7557
Fax: (901) 448-1716
Lab: 521 Johnson Building
Email: Lu Lu



Education

  • M.D. Institution: Nantong Medical College, Nantong, China
  • Postdoctoral: Columbia University, New York, NY; University of Tennessee, Memphis, TN

Research Interests

I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. RI mice are an excellent resource for these studies and allow us to examine multiple types of data in a reference population. In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. In combination with the previously developed BXD strains this is the largest RI strain set in existence.

Many problems can be efficiently addressed using RI mice. One of these questions is the mechanism of genetic control over brain architecture. In order to study this issue we have collected extensive neuroanatomical and gene expression data in the brains of BXD strains. Because all animals are isogenic, we can collect data of the same and differing types from multiple animals and meaningfully relate each data set. This allows us to determine, for instance, whether steady state expression of a gene is related to an observed phenotype, for instance an aspect of brain architecture or a behavioral difference between strains.

Another fascinating problem that we are able to address with RI lines is the modulation of transcriptional control in response to environmental influences. Using the LXS and BXD RI strains we are examining the modulation of transcriptional control in response to alcohol, stress, and the combination of alcohol and stress treatments. By examining modulatory changes in response to these conditions, we hope to gain insight into the molecular substrates underlying differences in ethanol and stress responses?a question thought to be very important in understanding human alcoholism.

Representative Publications

  • Walsh N, Zhang H, Hyland PL, Yang Q, Mocci E, Zhang M, Childs EJ, Collins I, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Canzian F, Duell EJ, Gallinger S, Giles GG, Goggins M, Goodman GE, Goodman PJ, Hung RJ, Kooperberg C, Kurtz RC, Malats N, LeMarchand L, Neale RE, Olson SH, Scelo G, Shu XO, Van Den Eeden SK, Visvanathan K, White E, Zheng W; PanScan and PanC4 consortia, Albanes D, Andreotti G, Babic A, Bamlet WR, Berndt SI, Borgida A, Boutron-Ruault MC, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Chaffee KG, Chanock S, Cleary S, Cotterchio M, Foretova L, Fuchs C, M Gaziano JM, Giovannucci E, Goggins M, Hackert T, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Herman J, Holcatova I, Holly EA, Hoover R, Hung RJ, Janout V, Klein EA, Kurtz RC, Laheru D, Lee IM, Lu L, Malats N, Mannisto S, Milne RL, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Real FX, Rothman N, Sesso HD, Severi G, Silverman D, Strobel O, Sund M, Thornquist MD, Tobias GS, Wactawski-Wende J, Wareham N, Weiderpass E, Wentzensen N, Wheeler W, Yu H, Zeleniuch-Jacquotte A, Kraft P, Li D, Jacobs EJ, Petersen GM, Wolpin BM, Risch HA, Amundadottir LT, Yu K, Klein AP, Stolzenberg-Solomon RZ. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer. J Natl Cancer Inst. 2018 Dec 12. doi: 10.1093/jnci/djy155. [Epub ahead of print] PubMed PMID: 30541042.
  • Chen Y, Zhu L, Ji L, Yang Y, Lu L, Wang X, Zhou G. Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK. Med Sci Monit. 2018 Dec 12;24:9007-9018. doi: 10.12659/MSM.912862. PubMed PMID: 30541014.
  • Ashbrook DG, Roy S, Clifford BG, Riede T, Scattoni ML, Heck DH, Lu L, Williams RW. Born to Cry: A Genetic Dissection of Infant Vocalization. Front Behav Neurosci. 2018 Oct 29;12:250. doi: 10.3389/fnbeh.2018.00250. eCollection 2018. PubMed PMID: 30420800; PubMed Central PMCID: PMC6216097.
  • Mulligan MK, Zhao W, Dickerson M, Arends D, Prins P, Cavigelli SA, Terenina E, Mormede P, Lu L, Jones BC. Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice. Front Genet. 2018 Sep 25;9:370. doi: 10.3389/fgene.2018.00370. eCollection 2018. PubMed PMID: 30319684; PubMed Central PMCID: PMC6167410.
  • Zhang FF, Hudson MM, Huang IC, Bhakta N, Ness KK, Brinkman TM, Klosky J, Lu L, Chen F, Ojha RP, Lanctot JQ, Robison LL, Krull KR. Lifestyle factors and health-related quality of life in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. Cancer. 2018 Oct 1;124(19):3918-3923. doi: 10.1002/cncr.31647. Epub 2018 Sep 11. PubMed PMID: 30204245; PubMed Central PMCID: PMC6226352.
  • Wilson CL, Howell CR, Partin RE, Lu L, Kaste SC, Mulrooney DA, Pui CH, Lanctot JQ, Srivastava DK, Robison LL, Hudson MM, Ness KK. Influence of fitness on health status among survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 Nov;65(11):e27286. doi: 10.1002/pbc.27286. Epub 2018 Jul 29. PubMed PMID: 30058279; PubMed Central PMCID: PMC6150801.

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