Lu Lu, M.D.
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-7557
Fax: (901) 448-1716
Lab: 521 Johnson Building
Email: Lu Lu
- M.D. Institution: Nantong Medical College, Nantong, China
- Postdoctoral: Columbia University, New York, NY; University of Tennessee, Memphis, TN
I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. RI mice are an excellent resource for these studies and allow us to examine multiple types of data in a reference population. In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. In combination with the previously developed BXD strains this is the largest RI strain set in existence.
Many problems can be efficiently addressed using RI mice. One of these questions is the mechanism of genetic control over brain architecture. In order to study this issue we have collected extensive neuroanatomical and gene expression data in the brains of BXD strains. Because all animals are isogenic, we can collect data of the same and differing types from multiple animals and meaningfully relate each data set. This allows us to determine, for instance, whether steady state expression of a gene is related to an observed phenotype, for instance an aspect of brain architecture or a behavioral difference between strains.
Another fascinating problem that we are able to address with RI lines is the modulation of transcriptional control in response to environmental influences. Using the LXS and BXD RI strains we are examining the modulation of transcriptional control in response to alcohol, stress, and the combination of alcohol and stress treatments. By examining modulatory changes in response to these conditions, we hope to gain insight into the molecular substrates underlying differences in ethanol and stress responses?a question thought to be very important in understanding human alcoholism.
- Jones BC, O'Callaghan JP, Lu L, Williams RW, Alam G, Miller DB. Genetic correlational analysis reveals no association between MPP(+) and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains. Neurotoxicol Teratol. 2014 Sep-Oct;45:91-2. doi: 10.1016/j.ntt.2014.08.005. Epub 2014 Sep 2. PubMed PMID: 25192776.
- Gu J, Lu L, Chen M, Xu L, Lan Q, Li Q, Liu Z, Chen G, Wang P, Wang X, Brand D, Olsen N, Zheng SG. TGF-Î²-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells. J Immunol. 2014 Oct 1;193(7):3388-97. doi: 10.4049/jimmunol.1400207. Epub 2014 Aug 25. PubMed PMID: 25156367.
- Huang Y, Zhu X, Wang L, Liu X, Lu L, Gu W, Jiao Y. Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains. ScientificWorldJournal. 2014;2014:584910. doi: 10.1155/2014/584910. Epub 2014 Jul 14. PubMed PMID: 25133246; PubMed Central PMCID: PMC4123512.
- Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand DD, Ryffel B, Horwitz DA, Quismorio FP, Liu Z, Li B, Olsen NJ, Zheng SG. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3432-40. doi: 10.1073/pnas.1408780111. Epub 2014 Aug 6. PubMed PMID: 25099355; PubMed Central PMCID: PMC4143025.
- Goldowitz D, Lussier AA, Boyle JK, Wong K, Lattimer SL, Dubose C, Lu L, Kobor MS, Hamre KM. Molecular pathways underpinning ethanol-induced neurodegeneration. Front Genet. 2014 Jul 15;5:203. doi: 10.3389/fgene.2014.00203. eCollection 2014. PubMed PMID: 25076964; PubMed Central PMCID: PMC4097813.
- Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE. Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9295-300. doi: 10.1073/pnas.1323543111. Epub 2014 Jun 10. PubMed PMID: 24927528; PubMed Central PMCID: PMC4078852.