Kazuko Sakata, Ph.D.

Kazuko Sakata, Ph.D.

Associate Professor
Department of Pharmacology
Department of Psychiatry


The University of Tennessee Health Science Center
874 Union Ave., Room 430 Crowe Research Building
Memphis, TN 38163
Phone: (901) 448-2662
Fax: (901) 448-7206
Email: Kazuko Sakata

 

Education

  • Ph.D. Institution: Osaka University School of Medicine, Osaka, Japan
  • Postdoctoral: Neural Development and Plasticity, National Institutes of Health

Research Interests

Our current projects in my laboratory focus on studying the roles of gene regulation of BDNF (Brain Derived Neurotrophic Factor) in depression and anxiety, using genetically modified mice. We study from gene to behavior, using molecular and biochemical, electrophysiological, and behavioral techniques.

Representative Publications

  • Sakata K, Overacre AE. Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. J Neurochem. 2017 Jul 19. doi: 10.1111/jnc.14129. [Epub ahead of print] PubMed PMID: 28722769.
  • Kim E, Sakata K, Liao FF. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation. PLoS Genet. 2017 Jul 5;13(7):e1006849. doi: 10.1371/journal.pgen.1006849. eCollection 2017 Jul. PubMed PMID: 28678786; PubMed Central PMCID: PMC5517072.
  • Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF. Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region. Mol Psychiatry. 2017 Jul;22(7):935. doi: 10.1038/mp.2017.125. PubMed PMID: 28638149.
  • Jha S, Dong BE, Xue Y, Delotterie DF, Vail MG, Sakata K. Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV. Transl Psychiatry. 2016 Sep 20;6(9):e896. doi: 10.1038/tp.2016.160. PubMed PMID: 27648918; PubMed Central PMCID: PMC5048201.
  • Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF. A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Mol Psychiatry. 2017 Jul;22(7):990-1001. doi: 10.1038/mp.2016.104. Epub 2016 Jul 26. PubMed PMID: 27457810; PubMed Central PMCID: PMC5323357.
  • Chen Y, Wang B, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci. 2014 Feb 12;34(7):2464-70. doi: 10.1523/JNEUROSCI.0151-13.2014. PubMed PMID: 24523537; PubMed Central PMCID: PMC3921421.

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