Kazuko Sakata, Ph.D.

Kazuko Sakata, Ph.D.

Associate Professor
Department of Pharmacology
Department of Psychiatry

The University of Tennessee Health Science Center
874 Union Ave., Room 430 Crowe Research Building
Memphis, TN 38163
Phone: (901) 448-2662
Fax: (901) 448-7206
Email: Kazuko Sakata



  • Ph.D. Institution: Osaka University School of Medicine, Osaka, Japan
  • Postdoctoral: Neural Development and Plasticity, National Institutes of Health

Research Interests

Our current projects in my laboratory focus on studying the roles of gene regulation of BDNF (Brain Derived Neurotrophic Factor) in depression and anxiety, using genetically modified mice. We study from gene to behavior, using molecular and biochemical, electrophysiological, and behavioral techniques.

Representative Publications

  • Jha S, Dong BE, Xue Y, Delotterie DF, Vail MG, Sakata K. Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV. Transl Psychiatry. 2016 Sep 20;6(9):e896. doi: 10.1038/tp.2016.160. PubMed PMID: 27648918; PubMed Central PMCID: PMC5048201.
  • Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF. A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Mol Psychiatry. 2016 Jul 26. doi: 10.1038/mp.2016.104. [Epub ahead of print] PubMed PMID: 27457810; PubMed Central PMCID: PMC5323357.
  • Chen Y, Wang B, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci. 2014 Feb 12;34(7):2464-70. doi: 10.1523/JNEUROSCI.0151-13.2014. PubMed PMID: 24523537; PubMed Central PMCID: PMC3921421.
  • Sakata K, Duke SM. Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus. Neuroscience. 2014 Feb 28;260:265-75. doi: 10.1016/j.neuroscience.2013.12.013. Epub 2013 Dec 15. PubMed PMID: 24345476.
  • Sakata K, Martinowich K, Woo NH, Schloesser RJ, Jimenez DV, Ji Y, Shen L, Lu B. Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15103-8. doi: 10.1073/pnas.1222872110. Epub 2013 Aug 26. PubMed PMID: 23980178; PubMed Central PMCID: PMC3773762.
  • Sakata K, Mastin JR, Duke SM, Vail MG, Overacre AE, Dong BE, Jha S. Effects of antidepressant treatment on mice lacking brain-derived neurotrophic factor expression through promoter IV. Eur J Neurosci. 2013 Jun;37(11):1863-74. doi: 10.1111/ejn.12148. Epub 2013 Feb 13. PubMed PMID: 23406189.

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