Kafait U. Malik, Ph.D.

Kafait U. Malik, Ph.D.

Department of Pharmacology

The University of Tennessee Health Science Center
216 Crowe Research Building
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-6075
Fax: (901) 448-7300
Email: Kafait U. Malik


  • D.Sc. Institution: University of Zagreb, Department of Pharmaceutics, Zagreb, Yugoslavia
  • Ph.D. Institution: University of Sarajevo, Department of Pharmacology, Sarajevo, Yugoslavia
  • Postdoctoral: University of Mainz, Department of Pharmacology, Mainz, W. Germany; University of Ottawa, Department of Pharmacology, Ottawa, Ontario


Research Interests

The objective of the research in this laboratory is to investigate the regulation of adrenergic neuroeffector events in the cardiovascular system. A variety of physiological, pharmacological, cellular and molecular techniques are used to define interaction of these neurohormonal systems in several experimental preparations of different species, both in vitro and in vivo.

The specific aims are: 1) characterization of receptors and the underlying signal transduction mechanisms (coupling of receptors to phospholipases via different G proteins) involved in adrenergically-induced release of arachidonic acid for prostaglandin synthesis; 2) investigation of the mechanism of action of arachidonic acid metabolites on release of the adrenergic transmitter ; and 3) examination of the mechanism of interaction of angiotensins and adrenergic nervous system in the regulation of cardiovascular function.

Representative Publications

  • Mukherjee K, Song CY, Estes AM, Dhodi AN, Ormseth BH, Shin JS, Gonzalez FJ, Malik KU. Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice. J Am Heart Assoc. 2018 Sep 18;7(18):e010065. doi: 10.1161/JAHA.118.010065. PubMed PMID: 30371217; PubMed Central PMCID: PMC6222936.
  • Sahan-Firat S, Temiz-Resitoglu M, Guden DS, Senol SP, Sari AN, Cil M, Unsal D, Korkmaz B, Tunctan B, Malik KU, Buharalioglu CK. NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock. Clin Exp Pharmacol Physiol. 2019 Feb;46(2):173-182. doi: 10.1111/1440-1681.13045. PubMed PMID: 30347478.
  • Zou Y, Chen Z, Jennings BL, Zhao G, Gu Q, Bhattacharya A, Cui Y, Yu B, Malik KU, Yue J. Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation. Sci Rep. 2018 Jan 23;8(1):1468. doi: 10.1038/s41598-018-19660-z. PubMed PMID: 29362439; PubMed Central PMCID: PMC5780492.
  • Song CY, Khan NS, Liao FF, Wang B, Shin JS, Bonventre JV, Malik KU. Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice. Am J Hypertens. 2018 Apr 13;31(5):622-629. doi: 10.1093/ajh/hpy009. PubMed PMID: 29342227; PubMed Central PMCID: PMC5905655.
  • Sahan-Firat S, Temiz-Resitoglu M, Guden DS, Kucukkavruk SP, Tunctan B, Sari AN, Kocak Z, Malik KU. Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB Signalling Pathway. Inflammation. 2018 Feb;41(1):276-298. doi: 10.1007/s10753-017-0686-2. PubMed PMID: 29110153.
  • Unsal D, Kacan M, Temiz-Resitoglu M, Guden DS, Korkmaz B, Sari AN, Buharalioglu CK, Yildirim-Yaroglu H, Tamer-Gumus L, Tunctan B, Malik KU, Sahan-Firat S. The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock. Clin Exp Pharmacol Physiol. 2018 Feb;45(2):155-165. doi: 10.1111/1440-1681.12864. Epub 2017 Nov 28. PubMed PMID: 28949404.

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