Kafait U. Malik, Ph.D.

Kafait U. Malik, Ph.D.

Department of Pharmacology

The University of Tennessee Health Science Center
216 Crowe Research Building
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-6075
Fax: (901) 448-7300
Email: Kafait U. Malik


  • D.Sc. Institution: University of Zagreb, Department of Pharmaceutics, Zagreb, Yugoslavia
  • Ph.D. Institution: University of Sarajevo, Department of Pharmacology, Sarajevo, Yugoslavia
  • Postdoctoral: University of Mainz, Department of Pharmacology, Mainz, W. Germany; University of Ottawa, Department of Pharmacology, Ottawa, Ontario


Research Interests

The objective of the research in this laboratory is to investigate the regulation of adrenergic neuroeffector events in the cardiovascular system. A variety of physiological, pharmacological, cellular and molecular techniques are used to define interaction of these neurohormonal systems in several experimental preparations of different species, both in vitro and in vivo.

The specific aims are: 1) characterization of receptors and the underlying signal transduction mechanisms (coupling of receptors to phospholipases via different G proteins) involved in adrenergically-induced release of arachidonic acid for prostaglandin synthesis; 2) investigation of the mechanism of action of arachidonic acid metabolites on release of the adrenergic transmitter ; and 3) examination of the mechanism of interaction of angiotensins and adrenergic nervous system in the regulation of cardiovascular function.

Representative Publications

  • Pingili AK, Davidge KN, Thirunavukkarasu S, Khan NS, Katsurada A, Majid DSA, Gonzalez FJ, Navar LG, Malik KU. 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. Hypertension. 2017 Apr 17. pii: HYPERTENSIONAHA.117.09175. doi: 10.1161/HYPERTENSIONAHA.117.09175. [Epub ahead of print] PubMed PMID: 28416584.
  • Temiz-Resitoglu M, Kucukkavruk SP, Guden DS, Cecen P, Sari AN, Tunctan B, Gorur A, Tamer-Gumus L, Buharalioglu CK, Malik KU, Sahan-Firat S. Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats. Eur J Pharmacol. 2017 May 5;802:7-19. doi: 10.1016/j.ejphar.2017.02.034. Epub 2017 Feb 20. PubMed PMID: 28228357.
  • Thirunavukkarasu S, Khan NS, Song CY, Ghafoor HU, Brand DD, Gonzalez FJ, Malik KU. Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. Am J Pathol. 2016 Aug;186(8):2204-19. doi: 10.1016/j.ajpath.2016.04.005. Epub 2016 Jun 11. PubMed PMID: 27301358; PubMed Central PMCID: PMC4973656.
  • Pingili AK, Thirunavukkarasu S, Kara M, Brand DD, Katsurada A, Majid DS, Navar LG, Gonzalez FJ, Malik KU. 6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice. Hypertension. 2016 May;67(5):916-26. doi: 10.1161/HYPERTENSIONAHA.115.06936. Epub 2016 Feb 29. PubMed PMID: 26928804; PubMed Central PMCID: PMC4833582.
  • Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock. Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13. PubMed PMID: 26875149.
  • Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL, Estes AM, Zaidi S, Bridges D, Tso P, Gonzalez FJ, Malik KU. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension. 2016 Jan;67(1):206-13. doi: 10.1161/HYPERTENSIONAHA.115.06427. Epub 2015 Nov 16. PubMed PMID: 26573711; PubMed Central PMCID: PMC4672747.

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