James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Moharramipour A, Mostame P, Hossein-Zadeh GA, Wheless JW, Babajani-Feremi A. Comparison of statistical tests in effective connectivity analysis of ECoG data. J Neurosci Methods. 2018 Sep 3. pii: S0165-0270(18)30262-0. doi: 10.1016/j.jneumeth.2018.08.026. [Epub ahead of print] PubMed PMID: 30189285.
  • Wheless JW, Phelps SJ. A Clinician's Guide to Oral Extended-Release Drug Delivery Systems in Epilepsy. J Pediatr Pharmacol Ther. 2018 Jul-Aug;23(4):277-292. doi: 10.5863/1551-6776-23.4.277. Review. PubMed PMID: 30181718; PubMed Central PMCID: PMC6117810.
  • Wheless JW, Gienapp AJ, Ryvlin P. Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav. 2018 Jul 12. pii: S1525-5050(18)30487-6. doi: 10.1016/j.yebeh.2018.06.032. [Epub ahead of print] Review. PubMed PMID: 30017839.
  • Babajani-Feremi A, Noorizadeh N, Mudigoudar B, Wheless JW. Predicting seizure outcome of vagus nerve stimulation using MEG-based network topology. Neuroimage Clin. 2018 Jun 18;19:990-999. doi: 10.1016/j.nicl.2018.06.017. eCollection 2018. PubMed PMID: 30003036; PubMed Central PMCID: PMC6039837.
  • Skalicky AM, Rentz AM, Liu Z, Said Q, Nakagawa JA, Frost MD, Wheless JW, Dunn DW. Economic burden, work, and school productivity in individuals with tuberous sclerosis and their families. J Med Econ. 2018 Jun 29:1-7. doi: 10.1080/13696998.2018.1487447. [Epub ahead of print] PubMed PMID: 29890870.
  • Kossoff EH, Zupec-Kania BA, Auvin S, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Guzel O, Jehle RS, Klepper J, Kang HC, Lambrechts DA, Liu YMC, Nathan JK, Nordli DR Jr, Pfeifer HH, Rho JM, Scheffer IE, Sharma S, Stafstrom CE, Thiele EA, Turner Z, Vaccarezza MM, van der Louw EJTM, Veggiotti P, Wheless JW, Wirrell EC; Charlie Foundation; Matthew's Friends; Practice Committee of the Child Neurology Society. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018 May 21;3(2):175-192. doi: 10.1002/epi4.12225. eCollection 2018 Jun. PubMed PMID: 29881797; PubMed Central PMCID: PMC5983110.

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