James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Russell GR, Phelps SJ, Shelton CM, Wheless JW. Impact of Drug Interactions on Clobazam and N-Desmethylclobazam Concentrations in Pediatric Patients with Epilepsy. Ther Drug Monit. 2018 May 4. doi: 10.1097/FTD.0000000000000530. [Epub ahead of print] PubMed PMID: 29746397.
  • Babajani-Feremi A, Holder CM, Narayana S, Fulton SP, Choudhri AF, Boop FA, Wheless JW. Predicting postoperative language outcome using presurgical fMRI, MEG, TMS, and high gamma ECoG. Clin Neurophysiol. 2018 Mar;129(3):560-571. doi: 10.1016/j.clinph.2017.12.031. Epub 2018 Jan 4. PubMed PMID: 29414401.
  • Mudigoudar B, Wheless JW. Response to Correspondence on "A Better Understanding of Brain Involvement in 22q11.2 Deletion Syndrome". Pediatr Neurol. 2018 Jan;78:e7. doi: 10.1016/j.pediatrneurol.2017.10.009. Epub 2017 Oct 12. PubMed PMID: 29174003.
  • Mudigoudar B, Nune S, Fulton S, Dayyat E, Wheless JW. Epilepsy in 22q11.2 Deletion Syndrome: A Case Series and Literature Review. Pediatr Neurol. 2017 Nov;76:86-90. doi: 10.1016/j.pediatrneurol.2017.08.011. Epub 2017 Aug 26. PubMed PMID: 28969878.
  • Wheless JW. Safety of Supratherapeutic Doses of Newer Antiepileptic Drugs in Children: What Have We Really Learned? J Pediatr Pharmacol Ther. 2017 Jul-Aug;22(4):244-245. doi: 10.5863/1551-6776-22.4.244. PubMed PMID: 28943816; PubMed Central PMCID: PMC5562201.
  • Papanicolaou AC, Wheless JW, Babajani-Feremi A, Narayana S, Rezaie R, Choudhri A, Boop F. Letter re: Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 Aug 8;89(6):640. doi: 10.1212/WNL.0000000000004204. PubMed PMID: 28784636.

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