James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Divison of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless


  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Papanicolaou AC, Rezaie R, Narayana S, Choudhri AF, Wheless JW, Castillo EM, Baumgartner JE, Boop FA. Is it time to replace the Wada test and put awake craniotomy to sleep? Epilepsia. 2014 May;55(5):629-32. doi: 10.1111/epi.12569. Epub 2014 May 9. PubMed PMID: 24815532.
  • Skalicky AM, Rentz AM, Liu Z, Wheless JW, Pelletier CL, Dunn DW, Frost MD, Nakagawa J, Magestro M, Prestifilippo J, Pashos C. The Burden of Subependymal Giant Cell Astrocytomas Associated With Tuberous Sclerosis Complex: Results of a Patient and Caregiver Survey. J Child Neurol. 2014 Mar 24. [Epub ahead of print] PubMed PMID: 24667738.
  • Choudhri AF, Narayana S, Rezaie R, Whitehead MT, McAfee SS, Wheless JW, Boop FA, Papanicolaou AC. Same day tri-modality functional brain mapping prior to resection of a lesion involving eloquent cortex: technical feasibility. Neuroradiol J. 2013 Oct;26(5):548-54. Epub 2013 Nov 7. PubMed PMID: 24199815.
  • Choudhri AF, Whitehead MT, McGregor AL, Einhaus SL, Boop FA, Wheless JW. Diffusion tensor imaging to evaluate commissural disconnection after corpus callosotomy. Neuroradiology. 2013 Nov;55(11):1397-403. doi: 10.1007/s00234-013-1286-y. Epub 2013 Oct 10. PubMed PMID: 24113714.
  • Wheless JW, Klimo P Jr. Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex:: Considerations for Surgical or Pharmacotherapeutic Intervention. J Child Neurol. 2013 Oct 7. [Epub ahead of print] PubMed PMID: 24105488.
  • Wheless JW, Almoazen H. A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex. J Child Neurol. 2013 Jul;28(7):933-6. doi: 10.1177/0883073813488664. Epub 2013 May 16. PubMed PMID: 23680945.

View more references (pubmed link)