James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Division of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless



  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Papanicolaou AC, Rezaie R, Narayana S, Choudhri AF, Abbas-Babajani-Feremi, Boop FA, Wheless JW. On the relative merits of invasive and non-invasive pre-surgical brain mapping: New tools in ablative epilepsy surgery. Epilepsy Res. 2017 Jul 3. pii: S0920-1211(17)30232-2. doi: 10.1016/j.eplepsyres.2017.07.002. [Epub ahead of print] PubMed PMID: 28716297.
  • Heck DH, McAfee SS, Liu Y, Babajani-Feremi A, Rezaie R, Freeman WJ, Wheless JW, Papanicolaou AC, Ruszinkó M, Sokolov Y, Kozma R. Breathing as a Fundamental Rhythm of Brain Function. Front Neural Circuits. 2017 Jan 12;10:115. doi: 10.3389/fncir.2016.00115. eCollection 2016. PubMed PMID: 28127277; PubMed Central PMCID: PMC5226946.
  • Fulton SP, Van Poppel K, McGregor AL, Mudigoudar B, Wheless JW. Vagus Nerve Stimulation in Intractable Epilepsy Associated With SCN1A Gene Abnormalities. J Child Neurol. 2017 Apr;32(5):494-498. doi: 10.1177/0883073816687221. Epub 2017 Jan 12. PubMed PMID: 28079431.
  • Babajani-Feremi A, Wheless JW, Papanicolaou JW, Wang Y, Fifer MS, Flinker A, Korzeniewska A, Cervenka MC, Anderson WS, Boatman-Reich DF, Crone NE. Spatial-temporal functional mapping of language at the bedside with electrocorticography. Neurology. 2016 Dec 13;87(24):2604. PubMed PMID: 27956570.
  • Tompson DJ, Buraglio M, Andrews SM, Wheless JW. Adolescent Clinical Development of Ezogabine/Retigabine as Adjunctive Therapy for Partial-Onset Seizures: Pharmacokinetics and Tolerability. J Pediatr Pharmacol Ther. 2016 Sep-Oct;21(5):404-412. PubMed PMID: 27877093; PubMed Central PMCID: PMC5103647.
  • Mudigoudar B, Weatherspoon S, Wheless JW. Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies. Semin Pediatr Neurol. 2016 May;23(2):167-79. doi: 10.1016/j.spen.2016.06.003. Epub 2016 Jun 4. PubMed PMID: 27544474.

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