James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Chair
Division of Pediatric Neurology
Le Bonheur Children's Hospital

Director
Le Bonheur Comprehensive Epilepsy Program


Director
Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless

 

Education

  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Tompson DJ, Buraglio M, Andrews SM, Wheless JW. Adolescent Clinical Development of Ezogabine/Retigabine as Adjunctive Therapy for Partial-Onset Seizures: Pharmacokinetics and Tolerability. J Pediatr Pharmacol Ther. 2016 Sep-Oct;21(5):404-412. PubMed PMID: 27877093; PubMed Central PMCID: PMC5103647.
  • Mudigoudar B, Weatherspoon S, Wheless JW. Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies. Semin Pediatr Neurol. 2016 May;23(2):167-79. doi: 10.1016/j.spen.2016.06.003. PubMed PMID: 27544474.
  • Babajani-Feremi A, Narayana S, Rezaie R, Choudhri AF, Fulton SP, Boop FA, Wheless JW, Papanicolaou AC. Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation. Clin Neurophysiol. 2016 Mar;127(3):1822-36. doi: 10.1016/j.clinph.2015.11.017. PubMed PMID: 26679420.
  • Rivas-Coppola MS, Shah N, Choudhri AF, Morgan R, Wheless JW. Chronological Evolution of Magnetic Resonance Imaging Findings in Children With Febrile Infection-Related Epilepsy Syndrome. Pediatr Neurol. 2016 Feb;55:22-9. doi: 10.1016/j.pediatrneurol.2015.09.003. PubMed PMID: 26597039.
  • Wheless JW. Use of the mTOR inhibitor everolimus in a patient with multiple manifestations of tuberous sclerosis complex including epilepsy. Epilepsy Behav Case Rep. 2015 Aug 12;4:63-6. doi: 10.1016/j.ebcr.2015.06.008. PubMed PMID: 26543807; PubMed Central PMCID: PMC4543076.
  • Brittain ST, Wheless JW. Pharmacokinetic simulations of topiramate plasma concentrations following dosing irregularities with extended-release vs. immediate-release formulations. Epilepsy Behav. 2015 Nov;52(Pt A):31-6. doi: 10.1016/j.yebeh.2015.08.029. PubMed PMID: 26409125.

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