James W. Wheless, M.D.

James W. Wheless, M.D.

Professor and Chief
Department of Pediatric Neurology

Divison of Pediatric Neurology
Le Bonheur Children's Hospital

Le Bonheur Comprehensive Epilepsy Program

Le Bonheur Neuroscience Center

Clinical Director and Chief
Department of Pediatric Neurology
St. Jude Children's Research Hospital

The University of Tennessee Health Science Center
Pediatric Neurology
777 Washington Avenue, Suite 335
Memphis, TN 38105
Phone: (901) 287-5207
Fax: (901) 287-5325
Email: James W. Wheless


  • M.D. Institution: University of Oklahoma, Oklahoma City
  • Residency & Fellowship Training: University of Oklahoma Tulsa Medical College, Tulsa; Child Neurology Fellow, Children's Memorial Hospital, Northwestern University, Chicago; EEG/Epilepsy Fellow, Medical College of Georgia, Augusta

Research Interests

My interests are seizure disorders and epilepsy in children and adolescents. This includes drug therapy, the ketogenic diet, epilepsy surgery, vagus nerve stimulation and magnetoencephalography.

Representative Publications

  • Brittain ST, Wheless JW. Pharmacokinetic simulations of topiramate plasma concentrations following dosing irregularities with extended-release vs. immediate-release formulations. Epilepsy Behav. 2015 Sep 23;52(Pt A):31-36. doi: 10.1016/j.yebeh.2015.08.029. [Epub ahead of print] PubMed PMID: 26409125.
  • Alford EL, Wheless JW, Phelps SJ. Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients. J Pediatr Pharmacol Ther. 2015 Jul-Aug;20(4):260-89. doi: 10.5863/1551-6776-20.4.260. Review. PubMed PMID: 26380568; PubMed Central PMCID: PMC4557718.
  • Gennarino VA, Alcott CE, Chen CA, Chaudhury A, Gillentine MA, Rosenfeld JA, Parikh S, Wheless JW, Roeder ER, Horovitz DD, Roney EK, Smith JL, Cheung SW, Li W, Neilson JR, Schaaf CP, Zoghbi HY. NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation. Elife. 2015 Aug 27;4. doi: 10.7554/eLife.10782. PubMed PMID: 26312503; PubMed Central PMCID: PMC4586391.
  • Patterson AL, Mudigoudar B, Fulton S, McGregor A, Poppel KV, Wheless MC, Brooks L, Wheless JW. SmartWatch by SmartMonitor: Assessment of Seizure Detection Efficacy for Various Seizure Types in Children, a Large Prospective Single-Center Study. Pediatr Neurol. 2015 Oct;53(4):309-11. doi: 10.1016/j.pediatrneurol.2015.07.002. Epub 2015 Jul 15. PubMed PMID: 26272007.
  • Choudhri AF, Patel RM, Siddiqui A, Whitehead MT, Wheless JW. Cortical Activation Through Passive-Motion Functional MRI. AJNR Am J Neuroradiol. 2015 Sep;36(9):1675-81. doi: 10.3174/ajnr.A4345. Epub 2015 Jul 30. PubMed PMID: 26228890.
  • Rivas-Coppola MS, Patterson AL, Morgan R, Wheless JW. Bupropion Overdose Presenting as Status Epilepticus in an Infant. Pediatr Neurol. 2015 Sep;53(3):257-61. doi: 10.1016/j.pediatrneurol.2015.05.018. Epub 2015 Jun 14. PubMed PMID: 26183178.

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