Francesca-Fang Liao, Ph.D.

Francesca-Fang Liao, Ph.D.

Professor
Department of Pharmacology


The University of Tennessee Health Science Center
874 Union Avenue
Memphis, TN 38163
Tel: (901) 448-2752
Fax: (901) 448-1822
Email: Francesca-Fang Liao

 

Education

  • Ph.D. Institution: Department of Molecular & Cellular Biology, Albert Einstein College of Medicine, New York
  • Postdoctoral: Laboratory of Cellular Physiology and Immuniology, The Rockefeller University, New York

Link

Research Interests

Molecular mechanism underlying neurotoxicity and neuroprotection.

  1. Study of the molecular mechanisms for the actions of several neuroprotective agents via activating the production of the soluble APP. Currently we conduct comparative studies in the in vitro and in vivo settings on the following chemical agents (statins, estrogen, melatonin, EGCG/anti-oxidant from green tea extract, and bryostatin/PKC activator).
  2. Study of novel functional roles of PTEN in adult CNS and in particular in neurodegeneration using Alzheimer mouse models. This study involves the following areas: 1) newly identified role of nuclear PTEN in neuronal cell cycle regulation 2) validation of the cell cycle hypothesis in neuronal degeneration and 3) redox regulation of PTEN as a crucial mechanism in neuronal function.
  3. Study of redox regulation of cell cycle regulators in neurons that contribute to neurodegeneration. We will employ both the acute (stroke) and chronic Alzheimer mouse models to investigate the interplay between PTEN, Akt, cell cycle molecules and neuronal death.
  4. Study of functional coupling between PTEN and a number of CNS receptors involved in drug addiction and in neuronal plasticity. Approaches will include structurefunction relationship analysis and eventually develop disruptive peptides/small molecule inhibitors as potential therapeutic interventions.

Representative Publications

  • Kim E, Sakata K, Liao FF. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation. PLoS Genet. 2017 Jul 5;13(7):e1006849. doi: 10.1371/journal.pgen.1006849. eCollection 2017 Jul. PubMed PMID: 28678786; PubMed Central PMCID: PMC5517072.
  • Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF. Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region. Mol Psychiatry. 2017 Jul;22(7):935. doi: 10.1038/mp.2017.125. PubMed PMID: 28638149.
  • Zhang C, Chen RX, Zhang Y, Wang J, Liu FY, Cai J, Liao FF, Xu FQ, Yi M, Wan Y. Erratum: Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain. Sci Rep. 2017 May 4;7:46778. doi: 10.1038/srep46778. PubMed PMID: 28471421; PubMed Central PMCID: PMC5417012.
  • Zheng J, Jiang YY, Xu LC, Ma LY, Liu FY, Cui S, Cai J, Liao FF, Wan Y, Yi M. Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes Differentially to Environmental Enrichment Combined with Voluntary Exercise in Alleviating Chronic Inflammatory Pain in Mice. J Neurosci. 2017 Apr 12;37(15):4145-4157. doi: 10.1523/JNEUROSCI.3333-16.2017. Epub 2017 Mar 14. PubMed PMID: 28292830.
  • Zhang C, Chen RX, Zhang Y, Wang J, Liu FY, Cai J, Liao FF, Xu FQ, Yi M, Wan Y. Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain. Sci Rep. 2017 Feb 2;7:41439. doi: 10.1038/srep41439. Erratum in: Sci Rep. 2017 May 04;7:46778. PubMed PMID: 28150719; PubMed Central PMCID: PMC5288727.
  • Zhang M, Liu J, Zhou MM, Wu H, Hou Y, Li YF, Yin Y, Zheng L, Cai J, Liao FF, Liu FY, Yi M, Wan Y. Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury. J Neurochem. 2017 Apr;141(1):137-150. doi: 10.1111/jnc.13965. Epub 2017 Mar 2. PubMed PMID: 28129443.

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