Types of Research

BIOMATERIALS RESEARCH

Listed below is a summary of the different types of research being conducted in the dental research centers across campus. This list is not exhaustive. To inquire about dental research at UT, please contact: Franklin Garcia-Godoy, D.D.S., M.S., Ph.D, Ph.D.

Biomaterials Development

  • Microtensile fracture strength testing
  • Profilometer fracture mode testing
  • Fatigue, thermocycling and load testing
  • Scanning electron microscope evaluation
  • Confocal electron microscope evaluation
  • Leakage testing
  • Hybrid layer evaluation
  • Remineralization and demineralization studies
  • Color and gloss analysis
  • Implant coatings

Clinical Testing

  • Whitening kits
  • Restorative materials
  • Endodontic materials
  • Periodontal therapies
  • Prosthodontic devices
  • Toothpaste
  • Mouthwash
  • Adhesives
  • Disinfectants
  • Analgesics
  • Drugs
  • Lasers
  • Dental instruments and devices
  • Toothbrushes (manual or power)
  • Ortho appliances/devices
  • Dental floss
  • Implants
  • Plaque and gingivitis

Toothbrushing

  • Dentifrice testing
  • Abrasion testing
  • Wear testing
  • Clinical testing
  • Biofilm

Biocompatibility Testing

  • Drugs and biomaterials
  • In vitro cytotoxicity
  • In vivo biocompatibility
  • Histological assessment
  • Genotoxicity assessment

Molecular Assays

  • Protein/Gene activation
  • PCR
  • Gene silencing
  • Gene isolation
  • Molecular pathway elucidation
  • Stem cells

CRANIOFACIAL RESEARCH

Inflammation Research

  • Tissue alterations in periodontal diseases
  • Cellular response to anti-inflammatory drugs (i.e., COX inhibitors, transcription factor inhibitors), natural products (i.e., myrrh oil, tea tree oil, cranberry components), and oral rinses
  • Levels of arachidonic acid metabolites in gingival crevicular fluid in gingivitis/periodontitis
  • Role of fibroblast production of matrix metalloproteinases and inflammatory mediators in periodontal diseases and inflammatory TMJ destruction
  • Effects of methamphetamine on gingival fibroblasts and neutrophils in periodontitis

Innate Immunity

  • Role of peroxidase enzymes of leukocytes and saliva in producing antimicrobial oxidizing agents that protect tissues against microbial infection and inflammation
  • Antibiotic peptides produced by human leukocytes, oral epithelial cells, and the salivary glands. Mechanisms of antimicrobial activity and the molecular basis for microbial resistance

Oral Cancer

  • Analysis of tumor cell invasion and metastatic potential
  • Testing therapeutic potential of anti-tumor agents
  • Immunolocalization of specific tumor antigens in cells and tissue

Proteomic Analysis and Protein Expression Patterns

  • Proteomic analysis of cells and tissues
  • Tumor marker identification, characterization, and prognostic value

Bone Metabolism

  • Effects of drugs (i.e., bisphosphonates and statins) and natural products (i.e., cranberry components) on soft tissue cell (gingival fibroblast and epithelial cell) production of mediators of bone metabolism (i.e., IL-6, RANKL, OPG)

Gingival Fibroses

  • Gingival fibroblast production/regulation of extracellular matrix molecules and matrix metalloproteinases in gingival fibroses (hereditary/idiopathic, drug-induced)

Molecular Assays

  • PCR
  • Bacterial gene isolation and gene product identification
  • Protein expression from isolated gene
  • DNA analysis

Clinical Testing

  • Assay for efficacy of mouthwash and toothpaste, using in vitro analysis
  • Evaluation of periodontal therapy products
  • Effects of natural products such as cannabidiol
  • Testing for biofilm in dental waterline (screening and enumeration of microbial populations in dental waterlines; culturing anaerobic bacteria)

Biomaterials Testing

  • Cellular and tissue response to implant materials and other biomaterials
  • Cytotoxicity of implant and other biomaterials
  • Genotoxicity testing
  • Biofilm formation

Craniofacial Pain

  • Therapy and treatment of neck and facial pain that is associated with temporomandibular joint disorders (TMD)
  • Treatment of sleep apnea and other sleep disordered breathing conditions through development and use of oral appliances
UTHSC Dental logo

Contact Us

Department of Bioscience Research
875 Union Avenue
Memphis, TN 38163

Senior Executive Associate Dean for Research
Franklin Garcia-Godoy, D.D.S., M.S., Ph.D., Ph.D.
Phone: (901) 448-6333