Hassan Almoazen, Ph.D.


Hassan Almoazen, Ph.D.

Assistant Professor

Office

Johnson Building Room 205T
847 Monroe Avenue
Memphis, TN 38163
Tel: (901) 448-2239
Fax: (901) 448-3446
Email: halmoaze@uthsc.edu

Office Hours

by appointment

Downloadable CVLink to Microsoft Word file

CURRICULUM VITAE

Degree

  • B.S. Pharmacy (Pharmaceutical Chemistry), Damascus University, College of Pharmacy, Syria.
  • Ph.D. Pharmaceutical Sciences (Pharmaceutics), Long Island University, Brooklyn, New York. (Major Advisor: Professor Anthony P. Simonelli)

Professional Experience

  • Assistant Professor, University of Tennessee, College of Pharmacy, Memphis, Tennessee, 2007- Current.
  • Assistant Professor, Drake University, College of Pharmacy, Des Moines, Iowa, 2003-2007.
  • Research Scientist, Wyeth Pharmaceutical, Pearl River, New York, 2002-2003.
  • Research Professional, Novartis Pharmaceutical, East Hanover, New Jersey, 2000.

Professional Affiliations

  • American Association of Pharmaceutical Scientists AAPS
  • American Chemical Society ACS
  • American Association of Colleges of Pharmacy AACP

Grants Awarded

  • Effect of Modifying the Structure of Benzyl Esters and the effect on Degradation in Sodium Dodecyl Sulfate Micelles. Approved and funded from Iowa Space Grant Consortium and NASA.
  • Characterizing Solubility of Benzyl Esters in Sodium Dodecyl Sulfate Micelles. Approved and funded from Drake Undergraduate Science Consortium Institute.
  • Enhancing Technology and Product Commercialization Through the Drake University College of Pharmacy & Health Sciences DELTA Rx Institute and Drake Undergraduate Science Collaboration Institute (DUSCI): Approved and funded by the Iowa board of regents Iowa value funds.
  • Determination of Surface Tensions/Energies of Benzyl Esters in Sodium Dodecyl Sulfate Surfactant Solutions. Approved and funded from Drake Undergraduate Science Consortium Institute.

RESEARCH INTERESTS

Dr. Almoazen’s research is focused on improving solubility and stability of drugs in dosage forms. A special emphasis is placed on understanding the mechanism of molecular degradation and the contributing factors leading to the instability of molecules. Techniques proposed to improve stability and solubility of drug molecules are complexation, cocrystal formation, altering crystal structure and incorporating the drug in colloidal dispersions such as micelles and emulsions.

SELECTED PUBLICATIONS

  1. Alternative high-performance liquid chromatography assay for p-aminohippuric acid (PAH): effect of aging on PAH excretion in the isolated perfused rat kidney. Ishani A. Savant, Michelle Kalis, Hassan Almoazen, Stephan R. Ortis, Malaz Abu Tarif and David R. Taft. Journal of Pharmaceutical and Biomedical Analysis 2001 December; 26 (5-6): 687-99.
  2. Investigation of solubility and Dissolution of Free base and two different salt forms as a function of pH. Shoufeng Li, SuiMing Wong, Sundeep Sethia, Hassan Almoazen, Yatindra M. Joshi, and Abu T. M. Serajuddin. Pharmaceutical Research, Vol. 22, No. 4, April 2005. P. 628-635
  3. Stability of Sotalol Hydrochloride in Extemporaneously Prepared Oral Suspension Formulations. Madiha Sidhom, Nadya Rivera, Hassan Almoazen, David Taft, and Harold Kirschenbaum. International Journal of Pharmaceutical Compounding, Vol. 9, No. 5, Sep/Oct 2005, P. 402-406.
  4. Lack of a Physicochemical Interaction between Metronidazole and Cholestyramine Geoffrey Wall, Hassan Almoazen, and Erik Maki. International Journal of Antimicrobial Agents, 2007, October 30 (4):372-4.
  5. Determining the Critical Micelle Concentration in O/W Emulsion Using the Rate Constant of Hydrolysis for Benzyl Acetate. Hassan Almoazen and Anthony P. Simonelli. Accepted for publication in the Journal of Dispersion Science and Technology.

Podium Presentations

  • Comparison study of the aggregation behavior of sodium dodecyl sulfate in o/w emulsion using the equilibrium distribution rate constant and reaction rate constant of benzyl acetate hydrolysis. 75th Colloidal and Surface Science Symposium, Carnegie Mellon University, Pittsburgh June 10-13th 2001.
  • Kinetic and mechanistic approach to study benzyl acetate hydrolysis in multiphasic system of o/w emulsion Graduate Research Association of Students of Pharmacy GRASP, XXI Annual meeting at the University of Connecticut, Storrs, June 8-10th 2001.
  • Studying the reaction kinetics of benzyl acetate hydrolysis in multiphasic system of O/W microemulsion. The 13th International symposium of surfactant in solution SIS, Florida, June 11th 2000.
  • Developing of a model to account for the reactant and product of benzyl acetate hydrolysis in multiphasic system of o/w emulsion. The 220th National meeting of the American Chemical Society ACS, Colloidal Society session Washington, DC August 24th 2000.

Poster Presentations

  • Characterization study of micellar partition coefficients of benzyl esters obtained through degradation kinetics with the ones determined in water/hydrophobic solvents.
    Alex Grill, Scott Newharth, Tram Hoang, Ngoc Dang, Melissa Odorzynski, Alex Bulochnik, Gholam Mirafzal* and Hassan Almoazen
    Annual Meeting of AAPS, San Antonio, Texas, AAPS Journal, Vol. 8, No. S2, 2006.
  • Characterizing reactivity of benzyl esters in sodium dodecyl sulfate micelles
    Melissa Odorzynski, Alex Bulochnik and Hassan Almoazen
    Annual Meeting of AAPS, Baltimore, Maryland, the AAPS Journal, Vol. 6, No. 4, abstract M1230, 2004.
  • Mathematical evaluation of the experimental activation energy to obtain the microenvironmental activation energy parameters for benzyl acetate alkaline hydrolysis in a biphasic system
    Mashfiqur Mandal, Hassan Almoazen and Anthony P. Simonelli
    The 226th ACS National Meeting, New York, NY, September 7-11, 2003.
  • Effect of salts form and diffusion layer pH on dissolution of a basic drug
    SuiMing Wong, Shoufeng Li, Sundeep Sethia, Hassan Almoazen, Stephanie Metz, Yatindra Joshi and Abu Serajuddin. Novartis Pharmaceuticals, Pharmaceutical Research and Development, East Hanover, New Jersey Presented at AAPS PDD meeting in Arlington, Virginia April 22-26 2002.
  • Comparison Study between Kinetic controlled and transport controlled hydrolysis reaction
    H Almoazen and AP. Simonelli
    AAPS PDD meeting in Arlington Virginia April 22-26 2002.
  • Mathematical Approach to determine kinetic and equilibrium parameters of hydrolysis reaction in multiphasic system “ case study I: o/w emulsion”
    H Almoazen and AP. Simonelli
    AAPS PDD meeting in Arlington Virginia April 22-26 2002.
  • Examination of surfactant behavior in triphasic o/w emulsion using benzyl acetate hydrolysis as a probe
    H Almoazen and AP. Simonelli
    AAPS Annual meeting Denver Colorado 2001 Abstract Published AAPS supplement Vol.3 No.3.
  • The Development and Use of ternary model to obtain kinetic parameters of drug hydrolysis in emulsions.
    H Almoazen and AP. Simonelli
    Pharmaceutical Congress of the Americas, March 24-29th Orlando Florida, 2001.
  • Evaluation of the micro-affinity of benzyl acetate in bi-phasic system of aqueous and micelles using kinetics and equilibrium studies.
    H Almoazen and AP. Simonelli
    Fourth Annual Meeting of the North Eastern Regional Discussion Group of AAPS, NERDG Connecticut, April 23rd 2001.
  • A novel method to determine the effective critical micelle concentration in o/w emulsion using the kinetic of benzyl acetate hydrolysis
    H Almoazen and AP. Simonelli
    AAPS National meeting Indianapolis Indiana 2000, AAPS supplement Vol.2 No.2
  • Studying the effect of the oil phase in o/w microemulsion on the reaction kinetic of benzyl acetate hydrolysis.
    H Almoazen and AP. Simonelli
    AAPS Annual meeting New Orleans Louisiana 1999, AAPS supplement Vol.1 No.4 S501.
  • Effect of aging on the disposition of para amino hippurate in isolated perfused rat kidney.
    H Almoazen and David R. Taft.
    AAPS Annual meeting San Francisco California 1998, AAPS supplement Vol.1 No.1 S465.
  • A new technique for conducting dissolution under constant hydrodynamic conditions
    Maysara Rabah, Anthony P. Simonelli, Fai Jim, Amar Venkatarangan and Hassan Almoazen
    The Sixteenth Annual Meeting of Graduate Research Association of Students in Pharmaceutics GRASP at the University of Georgia Athens May 30-June 1, 1996

Invited Speaker

  • Division of Pharmaceutics, College of Pharmacy, University of Iowa. Hydrolysis reactions of benzyl esters in colloidal systems. November, 28th 2005.

Scientific Reviewer

  • Journal of Pharmaceutical Research
  • International Journal of Pharmaceutics
  • American Journal of Pharmaceutical Education
  • Current Medical Research and Opinion
  • AAPS PharmSci Tech
  • International Journal of Pharmaceutical Compounding