Department of Pharmacology Faculty

Fu-Ming Zhou, Ph.D.

Fu-Ming Zhou, Ph.D.

Associate Professor
Crowe Building Room 315
Email: fzhou3@uthsc.edu
Phone: 901-448-1779
Fax: 901-448-7300

Education

  • M.D. -- SuZhou Medical College, SuZhou, China, 1985
  • Ph.D. -- Department of Physiology and Biophysics
    University of Alabama, Birmingham, Alabama, 1996
  • Postdoctoral Training -- Department of Neuroscience
    Baylor College Medicine, Houston, Texas

Research Interests

Dr. Zhou currently conducts a multidisciplinary research program designed to determine the molecular, cellular and neuropharmacological mechanisms of the brain monoamine systems. Particular attention is being paid to the contributions of these monoamine systems to neuropsychiatric disorders such as Parkinson's disease, depression, schizophrenia, drug abuse, and attention deficit hyperactivity disorder (ADHD). We use rodents as our experimental animals. Mutant mice are used in specific cases.

Several techniques are used in the laboratory:

  • Electrophysiology-patch clamp
  • Molecular biology (single cell RT-PCR in combination with patch clamp; gene expression profiling and manipulation)
  • Electrochemistry (fast cyclic voltammetry at the carbon fiber microelectrode; HPLC)
  • Immunohistochemistry (double and triple immunolabeling, confocal microscopy)

Funding

Dr. Zhou's research is funded by R01 grants from the National Institute on Drug Abuse and the National Institute of Mental Health and grants from private foundations.

Zhou research image

Publications

  1. Zhou FW, Jin Y, Matta SG, Xu M, Zhou F-M (2009) An ultra-short dopamine pathway regulates basal ganglia output neurons. J Neurosci 29:10424-35.
  2. Zhang T, Zhang, L, Liang Y, Siapas AG, Zhou F-M, Dani JA (2009) Dopamine signaling differences in the nucleus accumbens and striatum exploited by addictive nicotine. J Neurosci 29:4035-43.
  3. Zhou FW, Matta, SG, Zhou F-M (2008) Constitutively active TRPC3 channels regulate basal ganglia output neurons. J Neurosci. 28:473-482.
  4. Zhou F-M, Dani JA (2006) Antidepressants alter mesostriatal dopamine interactions with serotonin signaling. Current Psychiatry Reviews 2:453-461.
  5. Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou F-M (2006) Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. J Neurophysiol 96:1581-91.
  6. Chen R, Tilley MR, Wei H, Zhou F-W, Zhou F-M, Hill ER, Wei H, Nottoli T, Han DD, Gu HH (2006) Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc. Natl. Acad. Sci. USA 103:9333-8.
  7. Zhou F-M, Liang Y, Salas R, Zhang L, De Biasi M, Dani JA (2005) Co-release of dopamine and serotonin from striatal dopamine terminals. Neuron 46:65-74.
  8. Dani JA, De Biasi M, Liang Y, Peterson J, Zhang L, Zhang T, Zhou F-M (2004) Potential applications of nicotinic ligands in the laboratory and clinic. Bioorg Med Chem Lett. 14:1837-9.
  9. Dani JA, Zhou F-M (2004) Selective dopamine filter of glutamate striatal afferents. Neuron 42:522-524.
  10. Zhang L, Zhou F-M, Dani JA (2004) Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release. Mol. Pharmacol. 66:538-44.
  11. Zhou F-M, Wilson CJ, Dani JA (2003) Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. Neuroscientist 9:23-36.
  12. Zhou F-M, Wilson CJ, Dani JA (2002) Cholinergic interneuron characteristics and nicotinic properties in the striatum. J. Neurobiol. 53:590-605.
  13. Zhou F-M, Liang Y, Dani JA (2001) Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nat. Neurosci. 4:1224-1229.
  14. Dani JA, Ji D, Zhou F-M (2001) Synaptic plasticity and nicotine addiction. Neuron 31:349-352.
  15. Ennis M, Zhou F-M, Ciombor KJ, Aroniadou-Anderjaska V, Hayar A, Borrelli E, Zimmer LA, Margolis F, Shipley MT (2001) Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals. J. Neurophysiol. 86:2986-97.
  16. Chu Z-G, Zhou F-M, Hablitz JJ (2000) Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex. Brain Res. 887:399-405.
  17. Aroniadou-Anderjaska V, Zhou F-M, Priest CA, Ennis M, Shipley MT (2000) Tonic and synaptically evoked presynaptic inhibition of sensory input to the rat olfactory bulb via GABAB heteroreceptors. J Neurophysiol. 84:1194-1203.
  18. Zhou F-M, Hablitz JJ (1999) Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J. Neurophysiol. 82:2989-2999.
  19. Zhou F-M, Hablitz JJ (1999) Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex. J Neurophysiol. 81:967-976.
  20. Zhou F-M, Hablitz JJ (1998) Rapid kinetics of spontaneous EPSCs in rat neocortical layer II/III interneurons. Brain Res. 780:166-169.
  21. Zhou F-M, Hablitz JJ (1997) Metabotropic glutamate receptor enhancement of spontaneous IPSCs in rat neocortical interneurons. J. Neurophysiol. 78: 2287-2295.
  22. Zhou F-M, Hablitz JJ (1997) Rapid kinetics and inward rectification of miniature EPSCs in rat neocortical layer I neurons. J. Neurophysiol. 77: 2416-2426.
  23. Zhou F-M, Hablitz JJ (1996) Morphological properties of intracellularly labeled rat neocortical layer I neurons. J. Comp. Neurol. 376: 198-213.
  24. Zhou F-M, Hablitz JJ (1996) Rat neocortical layer I neurons. II. Voltage-dependent outward currents. J. Neurophysiol. 76: 668-681.
  25. Zhou F-M, Hablitz JJ (1996) Rat neocortical layer I neurons. I. Action potential and repetitive firing properties. J. Neurophysiol. 76: 651-667.
  26. Zhou F-M, Hablitz JJ (1996) Postnatal development of membrane properties of rat neocortical layer I neurons. J Neurosci. 16: 1131-1139.
  27. Zhou F-M, Hablitz JJ (1993) Zinc enhances GABAergic transmission in rat neocortical neurons. J. Neurophysiol. 70: 1264-1269.