Research Applications of TMS

Expanding a Neural Model of Speech Using Virtual Lesions and Connectivity Studies. R21 DC 009467-01A1, Shalini Narayana (PI)
The long-range goal of this research program is the development of a system-level model of the human speech-motor system that encompasses normal and disordered speech motor control. The goal of the current proposal is to test portions of the Directions into Velocities of Articulators (DIVA) a model of speech production that has both behavioral and neural components using transcranial magnetic stimulation and multimodal imaging.

Mechanisms of Action of TMS-Induced Performance Enhancement. VA merit award, PT Fox PI (University of Texas Health Science Center at San Antonio), Shalini Narayana Co-I.
The overall goal of this project is 1) to determine the mechanisms of action of short-term (single stimulation session) TMS-induced performance enhancement. 2) To determine the mechanisms of action of long-term (multiple stimulation sessions) TMS-induced performance enhancement.

Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in Baboons. R21 NS065431 Szabo PI (University of Texas Health Science Center at San Antonio), Shalini Narayana Co-I.
This study is part of an ongoing effort to develop a neurophysiological and neuroimaging model of photosensitive, generalized epilepsy in the baboon. TMS, PET and electrophysiological recordings are being used to develop a comprehensive neural network model of epilepsy.

A Baboon Model of TMS/PET As a Vehicle for Rational Development of TMS Treatments. R21 NS062254 PT Fox - PI (University of Texas Health Science Center at San Antonio), Shalini Narayana Co-I.
Ultimately, this work will lead to rational, theoretically grounded development of TMS as a treatment modality and as a tool for quantifying network property changes of TMS and other therapeutic modalities which modify local or network properties of neuronal populations.