Suleiman W. Bahouth, Ph.D.

Suleiman W. Bahouth, Ph.D.

Professor
Department of Pharmacology

The University of Tennessee
Health Science Center
Department of Medicine, Division of Cardiovascular Diseases
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-6009
Fax: (901) 448-7300
Lab: 309 Crowe Research Building
Email: Suleiman W. Bahouth



Education

  • Ph.D. Institution: New York University, Department of Pharmacology
  • Postdoctoral: State University of New York at Stony Brook, Department of Molecular Pharmacology

Links

Pharmacology - Suleiman W. Bahouth

Research Interests

My research program is focused on analyzing the mechanism(s) by which hormones and neurotransmitters regulate transmembranal signalling. The approach involves determining the regions in G protein coupled receptors and GTP binding regulatory proteins (G proteins) that are involved in regulating the sensitivity of the cell to hormones and neurotransmitters.

The sensitivity of the heart to the neurotransmitter norepinephrine or to its circulating counterpart epinephrine, is profoundly influenced by thyroid hormones (T3). In the heart, it appears that the dominant receptor mediating the functions of catecholamines is the beta-adrenergic receptor. T3 upregulate the number of beta-adrenergic receptors in the heart cell and increase their sensitivity to catecholamines. With respect to the receptor, T3 exert their effects by increasing the transcription of the beta-adrenergic receptor gene. The goal of our ongoing studies is to identify the cis-acting DNA sequences in the beta-adrenergic receptor gene and trans-acting nuclear proteins that are involved in the stimulation of beta-adrenergic receptor gene transcription by T3.

The sensitivity of the receptor to catecholamines is modulated by T3 through a complex mechanism operating at a point distal to the receptor. Activation of the beta-adrenergic receptor results in the initiation of a cascade that results in the generation of the intracellular messenger cyclic AMP. The activity of the effector enzyme that catalyzes the conversion of ATP to cyclic AMP is regulated by G proteins. Our studies are focused on identifying the mechanism by which T3 regulate the abundance and coupling of G proteins to the receptor and effector.

Representative Publications

  • Nooh MM, Chumpia MM, Hamilton TB, Bahouth SW. Sorting of β1-adrenergic receptors is mediated by pathways that are either dependent on or independent of type I PDZ, protein kinase A (PKA), and SAP97. J Biol Chem. 2014 Jan 24;289(4):2277-94. doi: 10.1074/jbc.M113.513481. Epub 2013 Dec 9. PubMed PMID: 24324269; PubMed Central PMCID: PMC3900972.
  • Li X, Nooh MM, Bahouth SW. Role of AKAP79/150 protein in β1-adrenergic receptor trafficking and signaling in mammalian cells. J Biol Chem. 2013 Nov 22;288(47):33797-812. doi: 10.1074/jbc.M113.470559. Epub 2013 Oct 11. PubMed PMID: 24121510; PubMed Central PMCID: PMC3837123.
  • Fain JN, Company JM, Booth FW, Laughlin MH, Padilla J, Jenkins NT, Bahouth SW, Sacks HS. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism. 2013 Oct;62(10):1503-11. doi: 10.1016/j.metabol.2013.05.021. Epub 2013 Jul 5. PubMed PMID: 23831442; PubMed Central PMCID: PMC3779497.
  • Sacks HS, Fain JN, Bahouth SW, Ojha S, Frontini A, Budge H, Cinti S, Symonds ME. Adult epicardial fat exhibits beige features. J Clin Endocrinol Metab. 2013 Sep;98(9):E1448-55. doi: 10.1210/jc.2013-1265. Epub 2013 Jul 3. PubMed PMID: 23824424.
  • Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW. SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. PLoS One. 2013 May 16;8(5):e63379. doi: 10.1371/journal.pone.0063379. Print 2013. PubMed PMID: 23696820; PubMed Central PMCID: PMC3656048.
  • Hajjhussein H, Gardner LA, Fujii N, Anderson NM, Bahouth SW. The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the β(1)-adrenergic receptor to G(s). J Recept Signal Transduct Res. 2013 Apr;33(2):79-88. doi: 10.3109/10799893.2012.759590. Epub 2013 Jan 25. PubMed PMID: 23351074.

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