Michael R. Taylor, Ph.D.

Michael R. Taylor, Ph.D.

Assistant Member
Department of Chemical Biology and Therapeutics
St. Jude Children's Research Hospital

Affiliated Assistant Professor
Department of Anatomy and Neurobiology


St. Jude Children's Research Hospital
262 Danny Thomas Place, MS-1000
Memphis, TN 38105-3678
Tel: (901) 595-6269
Email: Michael R. Taylor



Education

  • Ph.D. Institution: Department of Biochemistry, University of Washington, Seattle
  • Postdoctoral: University of Washington; University of California, San Francisco

Link

St. Jude Faculty - Michael Taylor

Research Interests

  • Establishing zebrafish as a model to study blood-brain barrier function and development.
  • Characterizing and cloning zebrafish mutants with synaptic transmission defects.
  • Developing high-throughput and high-content small-molecule screens aimed to identify biologically-active compounds.

Representative Publications

  • Ju B, Chen W, Orr BA, Spitsbergen JM, Jia S, Eden CJ, Henson HE, Taylor MR. Oncogenic KRAS promotes malignant brain tumors in zebrafish. Mol Cancer. 2015 Feb 3;14(1):18. [Epub ahead of print] PubMed PMID: 25644510; PubMed Central PMCID: PMC4320811.
  • Henson HE, Parupalli C, Ju B, Taylor MR. Functional and genetic analysis of choroid plexus development in zebrafish. Front Neurosci. 2014 Nov 10;8:364. doi: 10.3389/fnins.2014.00364. eCollection 2014. PubMed PMID: 25426018; PubMed Central PMCID: PMC4226144.
  • Eden CJ, Ju B, Murugesan M, Phoenix TN, Nimmervoll B, Tong Y, Ellison DW, Finkelstein D, Wright K, Boulos N, Dapper J, Thiruvenkatam R, Lessman CA, Taylor MR, Gilbertson RJ. Orthotopic models of pediatric brain tumors in zebrafish. Oncogene. 2015 Mar 26;34(13):1736-1742. doi: 10.1038/onc.2014.107. Epub 2014 Apr 21. PubMed PMID: 24747973; PubMed Central PMCID: PMC4205223.
  • Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, Easton J, Edmonson M, Ma X, Lu C, Nagahawatte P, Hedlund E, Rusch M, Pounds S, Lin T, Onar-Thomas A, Huether R, Kriwacki R, Parker M, Gupta P, Becksfort J, Wei L, Mulder HL, Boggs K, Vadodaria B, Yergeau D, Russell JC, Ochoa K, Fulton RS, Fulton LL, Jones C, Boop FA, Broniscer A, Wetmore C, Gajjar A, Ding L, Mardis ER, Wilson RK, Taylor MR, Downing JR, Ellison DW, Zhang J, Baker SJ; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014 May;46(5):444-50. doi: 10.1038/ng.2938. Epub 2014 Apr 6. PubMed PMID: 24705251; PubMed Central PMCID: PMC4056452.
  • Ju B, Chen W, Spitsbergen JM, Lu J, Vogel P, Peters JL, Wang YD, Orr BA, Wu J, Henson HE, Jia S, Parupalli C, Taylor MR. Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis. 2014 Mar 31;3:e96. doi: 10.1038/oncsis.2014.10. PubMed PMID: 24686726; PubMed Central PMCID: PMC4038393.
  • Jia S, Muto A, Orisme W, Henson HE, Parupalli C, Ju B, Baier H, Taylor MR. Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation. Hum Mol Genet. 2014 Jun 1;23(11):2981-94. doi: 10.1093/hmg/ddu009. Epub 2014 Jan 12. PubMed PMID: 24419318; PubMed Central PMCID: PMC4014194.

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