Mark S. LeDoux, M.D., Ph.D.

Mark S. LeDoux, M.D., Ph.D.

Department of Neurology Department of Anatomy and Neurobiology

Division of Movement Disorders

Dystonia and Huntington Disease Clinics

Movement Disorders Research Laboratories

The University of Tennessee Health Science Center
855 Monroe Avenue
Suite 415 Link Building
Memphis, TN 38163
Phone: (901) 448-1662
Fax: (901) 448-7440
Email: Mark S. LeDoux



  • M.D. Institution: Louisiana State University School of Medicine
  • Ph.D. Institution: University of Alabama, Birmingham, Department of Neuroscience
  • Residency Training: University of Alabama at Birmingham; University of Tennessee Health Science Center


Research Interests

  • Genetics and pathobiology of primary dystonia
    • Using vertebrate and invertebrate models, human lymphoblastoid and fibroblast cell lines, and stable transfected cell lines, we study the cellular and systems biology of dystonia-associated proteins.
    • Genetic contributions to late-onset primary dystonia are being examined with whole-exome and whole genome sequencing with integrated linkage analysis and RNA-seq. We also utilize candidate gene, genome-wide association and whole-genome gene expression studies.
  • Mechanisms of neurodegeneration in Parkinson disease: several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson disease. To examine the potential role of TIQs in monoaminergic cell death, we have used enantiomeric-selective high-performance liquid chromatography with electrochemical detection, liquid chromatography with tandem mass spectroscopy, cell culture studies of neurotoxicity and assays of mitochondrial membrane potential.
  • Clinical trials of therapeutic interventions for movement disorders (dystonia, Huntington disease, Parkinson disease, restless legs syndrome)
  • Anatomy and computational organization of motor systems
    • The neural networks mediating suprasegmental control of the blink reflex and spontaneous blinking remain poorly understood. Viral transneuronal tracing is being used to define the integrated premotor cortical and subcortical control of levator palpebrae and orbicularis oculi motoneuron activity.
    • In isolation or via interactions with striatal-thalamo-cortical pathways, olivocerebellar structures play a critical role in disorders of motor control such as ataxia and dystonia. Using neurophysiological and molecular tools, we are dissecting the relative roles of individual network elements in the positive and negative signs characteristic of individual movement disorders.

Clinical Subspecialty Expertise

Adult and Pediatric Movement Disorders, Botulinum Toxin for Dystonia and Spasticity, Deep Brain Stimulation

Representative Publications

  • Hope KA, LeDoux MS, Reiter LT. The Drosophila melanogaster homolog of UBE3A is not imprinted in neurons. Epigenetics. 2016 Aug 11:1-6. [Epub ahead of print] PubMed PMID: 27599063.
  • Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Exp Neurol. 2016 Sep;283(Pt A):110-20. doi: 10.1016/j.expneurol.2016.05.006. Epub 2016 May 7. PubMed PMID: 27163549; PubMed Central PMCID: PMC4992595.
  • LeDoux MS, Vemula SR, Xiao J, Thompson MM, Perlmutter JS, Wright LJ, Jinnah HA, Rosen AR, Hedera P, Comella CL, Weissbach A, Junker J, Jankovic J, Barbano RL, Reich SG, Rodriguez RL, Berman BD, Chouinard S, Severt L, Agarwal P, Stover NP. Clinical and genetic features of cervical dystonia in a large multicenter cohort. Neurol Genet. 2016 Apr 11;2(3):e69. doi: 10.1212/NXG.0000000000000069. eCollection 2016 Jun. PubMed PMID: 27123488; PubMed Central PMCID: PMC4830199.
  • Xiao J, Thompson MM, Vemula SR, LeDoux MS. Blepharospasm in a multiplex African-American pedigree. J Neurol Sci. 2016 Mar 15;362:299-303. doi: 10.1016/j.jns.2016.02.003. Epub 2016 Feb 2. PubMed PMID: 26944167; PubMed Central PMCID: PMC4779500.
  • Murgai AA, LeDoux MS. Memantine-induced Myoclonus in a Patient with Alzheimer Disease. Tremor Other Hyperkinet Mov (N Y). 2015 Aug 14;5:337. doi: 10.7916/D8ZG6RD9. eCollection 2015. PubMed PMID: 26317045; PubMed Central PMCID: PMC4548970.
  • Li C, Fitzgerald ME, Del Mar N, Cuthbertson-Coates S, LeDoux MS, Gong S, Ryan JP, Reiner A. The identification and neurochemical characterization of central neurons that target parasympathetic preganglionic neurons involved in the regulation of choroidal blood flow in the rat eye using pseudorabies virus, immunolabeling and conventional pathway tracing methods. Front Neuroanat. 2015 Jun 2;9:65. doi: 10.3389/fnana.2015.00065. eCollection 2015. PubMed PMID: 26082687; PubMed Central PMCID: PMC4451581.

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