Malinda E.C. Fitzgerald, Ph.D.

Malinda E.C. Fitzgerald, Ph.D.

Professor
Department of Biology
Christian Brothers University

Adjunct Professor
Department of Anatomy and Neurobiology


Christian Brothers University
650 E. Parkway S.
Memphis, TN 38104
Phone: (901) 321-3262
Fax: (901) 321-4433
Email: Malinda E.C. Fitzgerald



Education

  • Ph.D. Institution: The University of Tennessee Health Science Center
  • Postdoctoral: The University of Tennessee Health Science Center

Link

Minority Health and Health Disparities International Research Training (MHIRT) Program

Christian Brothers University - Malinda E.C. Fitzgerald

Research Interests

Age-related macular degeneration (AMD) and diabetes are two ocular diseases that are responsible for most of the new blindness that occurs in the United States. In both diseases, new vessel growth and decreased blood flow occur in the eye. My research involves investigating the nature, basis and consequences of vascular abnormalities in the eye during these, and related, diseases. There are two vascular beds in most mammalian eyes that provide the blood supply to the retina. The inner retinal vessels, which originate from the central retinal artery, and the outer vascular bed termed the choroid, which originates from the ciliary arteries. One focus of my research has been to investigate the cell biological basis of retinal vascular endothelial cell proliferation, particularly the mechanisms controlling cell growth and migration within the eye. While the precise location of the new vessel growth is different in diabetes and AMD, they have a common result, ocular pathology. Parallel to this research, I have studied the role of the choroidal vasculature in retinal health. The choroid is the major vascular supply of the retina, yet little is known about the possible role that impairments in choroidal blood flow (ChBF) or its regulation may play in retinal disease. Decreases in ChBF may contribute to the etiology or progression of diseases such as, myopia, AMD, or glaucoma. Since decreased ChBF and vascular proliferation affect the health of the retina, research on the mechanisms controlling these vascular functions will provide information on the role of the normal vascular function in supporting retinal health and the role of defective vascular function in contributing to retinal disease.

I use an avian model (pigeons) and a variety of techniques in my research, electron microscopy, electrophysiology, pharmacology, biochemistry, cell and molecular biology in order to investigate the effects of vascular disease on the health of the retina.

Representative Publications

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