Lu Lu, M.D.
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-7557
Fax: (901) 448-1716
Lab: 521 Johnson Building
Email: Lu Lu
- M.D. Institution: Nantong Medical College, Nantong, China
- Postdoctoral: Columbia University, New York, NY; University of Tennessee, Memphis, TN
I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. RI mice are an excellent resource for these studies and allow us to examine multiple types of data in a reference population. In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. In combination with the previously developed BXD strains this is the largest RI strain set in existence.
Many problems can be efficiently addressed using RI mice. One of these questions is the mechanism of genetic control over brain architecture. In order to study this issue we have collected extensive neuroanatomical and gene expression data in the brains of BXD strains. Because all animals are isogenic, we can collect data of the same and differing types from multiple animals and meaningfully relate each data set. This allows us to determine, for instance, whether steady state expression of a gene is related to an observed phenotype, for instance an aspect of brain architecture or a behavioral difference between strains.
Another fascinating problem that we are able to address with RI lines is the modulation of transcriptional control in response to environmental influences. Using the LXS and BXD RI strains we are examining the modulation of transcriptional control in response to alcohol, stress, and the combination of alcohol and stress treatments. By examining modulatory changes in response to these conditions, we hope to gain insight into the molecular substrates underlying differences in ethanol and stress responses?a question thought to be very important in understanding human alcoholism.
- Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A. Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function. PLoS One. 2016 Mar 31;11(3):e0152581. doi: 10.1371/journal.pone.0152581. eCollection 2016. PubMed PMID: 27031617; PubMed Central PMCID: PMC4816557.
- Lu H, Lu L, Williams RW, Jablonski MM. Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice. Mol Vis. 2016 Mar 4;22:224-33. eCollection 2016. PubMed PMID: 27011731; PubMed Central PMCID: PMC4783577.
- Boland AM, Gibson TM, Lu L, Kaste SC, DeLany JP, Partin RE, Lanctot JQ, Howell CR, Nelson HH, Chemaitilly W, Pui CH, Robison LL, Mulrooney DA, Hudson MM, Ness KK. Dietary Protein Intake and Lean Muscle Mass in Survivors of Childhood Acute Lymphoblastic Leukemia: Report From the St. Jude Lifetime Cohort Study. Phys Ther. 2016 Feb 18. [Epub ahead of print] PubMed PMID: 26893509.
- Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW. Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun. 2016 Feb 2;7:10464. doi: 10.1038/ncomms10464. PubMed PMID: 26833085; PubMed Central PMCID: PMC4740880.
- Lu L, Pandey AK, Houseal MT, Mulligan MK. The Genetic Architecture of Murine Glutathione Transferases. PLoS One. 2016 Feb 1;11(2):e0148230. doi: 10.1371/journal.pone.0148230. eCollection 2016. PubMed PMID: 26829228; PubMed Central PMCID: PMC4734686.
- Urquhart KR, Zhao Y, Baker JA, Lu Y, Yan L, Cook MN, Jones BC, Hamre KM, Lu L. A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors. Neurogenetics. 2016 Apr;17(2):91-105. doi: 10.1007/s10048-015-0470-0. Epub 2016 Jan 18. PubMed PMID: 26780340.