Lu Lu, M.D.
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-7557
Fax: (901) 448-1716
Lab: 521 Johnson Building
Email: Lu Lu
- M.D. Institution: Nantong Medical College, Nantong, China
- Postdoctoral: Columbia University, New York, NY; University of Tennessee, Memphis, TN
I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. RI mice are an excellent resource for these studies and allow us to examine multiple types of data in a reference population. In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. In combination with the previously developed BXD strains this is the largest RI strain set in existence.
Many problems can be efficiently addressed using RI mice. One of these questions is the mechanism of genetic control over brain architecture. In order to study this issue we have collected extensive neuroanatomical and gene expression data in the brains of BXD strains. Because all animals are isogenic, we can collect data of the same and differing types from multiple animals and meaningfully relate each data set. This allows us to determine, for instance, whether steady state expression of a gene is related to an observed phenotype, for instance an aspect of brain architecture or a behavioral difference between strains.
Another fascinating problem that we are able to address with RI lines is the modulation of transcriptional control in response to environmental influences. Using the LXS and BXD RI strains we are examining the modulation of transcriptional control in response to alcohol, stress, and the combination of alcohol and stress treatments. By examining modulatory changes in response to these conditions, we hope to gain insight into the molecular substrates underlying differences in ethanol and stress responses?a question thought to be very important in understanding human alcoholism.
- Delprato A, Bonheur B, Algéo MP, Rosay P, Lu L, Williams RW, Crusio WE. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. 2015 Oct 9. doi: 10.1111/gbb.12259. [Epub ahead of print] Review. PubMed PMID: 26449520.
- Zhao W, Zhao T, Chen Y, Zhao F, Gu Q, Williams RW, Bhattacharya SK, Lu L, Sun Y. A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain. PLoS One. 2015 Aug 4;10(8):e0133132. doi: 10.1371/journal.pone.0133132. eCollection 2015. PubMed PMID: 26241864; PubMed Central PMCID: PMC4524617.
- Ashbrook DG, Williams RW, Lu L, Hager R. A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder. Front Behav Neurosci. 2015 Jul 1;9:171. doi: 10.3389/fnbeh.2015.00171. eCollection 2015. PubMed PMID: 26190982; PubMed Central PMCID: PMC4486840.
- Xue Y, Li J, Yan L, Lu L, Liao FF. Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. Behav Brain Res. 2015 Oct 1;292:83-94. doi: 10.1016/j.bbr.2015.06.023. Epub 2015 Jun 16. PubMed PMID: 26092713.
- Cook MN, Baker JA, Heldt SA, Williams RW, Hamre KM, Lu L. Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. Physiol Genomics. 2015 Aug;47(8):308-17. doi: 10.1152/physiolgenomics.00114.2014. Epub 2015 May 19. PubMed PMID: 25991709; PubMed Central PMCID: PMC4525077.
- Ness KK, DeLany JP, Kaste SC, Mulrooney DA, Pui CH, Chemaitilly W, Karlage RE, Lanctot JQ, Howell CR, Lu L, Srivastava DK, Robison LL, Hudson MM. Energy balance and fitness in adult survivors of childhood acute lymphoblastic leukemia. Blood. 2015 May 28;125(22):3411-9. doi: 10.1182/blood-2015-01-621680. Epub 2015 Mar 26. PubMed PMID: 25814529; PubMed Central PMCID: PMC4447859.