J. Paul Taylor, M.D., Ph.D.

J. Paul Taylor, M.D., Ph.D.

Adjunct Member/Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center


Primary Appointment: St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6047
Fax: (901) 595-5947
Email: J. Paul Taylor



Education

  • M.D./Ph.D. Institution: Jefferson Medical College, Philadelphia, PA
  • Neurology Residency: Hospital of the University of Pennsylvania
  • Neurogenetics Fellowship: Neurogenetics Branch, NINDS/NIH

Link

Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
  • Screen small molecules to identify compounds that can be translated to clinical use

Representative Publications

  • Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015 Aug 26. doi: 10.1038/nature14974. [Epub ahead of print] PubMed PMID: 26308899.
  • Taylor JP. Multisystem proteinopathy: Intersecting genetics in muscle, bone, and brain degeneration. Neurology. 2015 Aug 25;85(8):658-60. doi: 10.1212/WNL.0000000000001862. Epub 2015 Jul 24. PubMed PMID: 26208960.
  • Oh SY, He F, Krans A, Frazer M, Taylor JP, Paulson HL, Todd PK. RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Hum Mol Genet. 2015 Aug 1;24(15):4317-26. doi: 10.1093/hmg/ddv165. Epub 2015 May 7. PubMed PMID: 25954027; PubMed Central PMCID: PMC4492395.
  • Norris KL, Hao R, Chen LF, Lai CH, Kapur M, Shaughnessy PJ, Chou D, Yan J, Taylor JP, Engelender S, West AE, Lim KL, Yao TP. Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. J Biol Chem. 2015 May 29;290(22):13862-74. doi: 10.1074/jbc.M114.634063. Epub 2015 Apr 10. PubMed PMID: 25861987; PubMed Central PMCID: PMC4447961.
  • Sanhueza M, Chai A, Smith C, McCray BA, Simpson TI, Taylor JP, Pennetta G. Network analyses reveal novel aspects of ALS pathogenesis. PLoS Genet. 2015 Mar 31;11(3):e1005107. doi: 10.1371/journal.pgen.1005107. eCollection 2015 Mar. PubMed PMID: 25826266; PubMed Central PMCID: PMC4380362.
  • Scoto M, Rossor AM, Harms MB, Cirak S, Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A, Mansour S, Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, Overweg-Plandsoen WC, Baas F, Taylor JP, Benatar M, Connolly AM, Al-Lozi MT, Nixon J, de Goede CG, Foley AR, Mcwilliam C, Pitt M, Sewry C, Phadke R, Hafezparast M, Chong WK, Mercuri E, Baloh RH, Reilly MM, Muntoni F. Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology. 2015 Feb 17;84(7):668-79. doi: 10.1212/WNL.0000000000001269. Epub 2015 Jan 21. PubMed PMID: 25609763; PubMed Central PMCID: PMC4336105.

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