Jena J. Steinle, Ph.D.

Jena J. Steinle, Ph.D.

Associate Professor
Department of Ophthalmology
Department of Anatomy and Neurobiology
Hamilton Eye Institute


The University of Tennessee Health Science Center
930 Madison Ave, Suite 768A
Memphis, TN 38163
Tel: (901) 448-1910
Fax: (901) 448-5028
Email: Jena J. Steinle



Education

  • Ph.D. Institution: University of Kansas Medical Center, Kansas City, KS
  • Postdoctoral: Texas A&M University Health Science Center, Temple, TX

Links

Ophthalmology - Jena Steinle

Research Interests

Research in our lab investigates changes in the choroid and retina in age-related macular degeneration and diabetic retinopathy. We are currently working on the effects of loss in sympathetic innervation (the fight or flight system) on the retinal pathology associated with diabetic retinopathy and choroidal pathology with macular degeneration. We use modern cellular and molecular biology techniques on cell culture and animal samples to evaulate the mechanisms for the disease processes. We are also interested in the interactions between sympathetic nerves and the vasculature they innervate.

Representative Publications

  • Jiang Y, Zhang Q, Steinle JJ. Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina. PLoS One. 2014 Apr 2;9(4):e93788. doi: 10.1371/journal.pone.0093788. eCollection 2014. PubMed PMID: 24695399; PubMed Central PMCID: PMC3973588.
  • He H, Williams-Guy K, Pagadala J, Presley CS, Miller DD, Steinle JJ, Yates CR. A sensitive and fast LC-MS/MS method for determination of β-receptor agonist JP-49b: Application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:86-91. doi: 10.1016/j.jchromb.2014.01.031. Epub 2014 Feb 8. PubMed PMID: 24576769; PubMed Central PMCID: PMC3985067.
  • Zhang Q, Jiang Y, Toutounchian J, Wilson MW, Morales-Tirado V, Miller DD, Yates CR, Steinle JJ. Novel quinic acid derivative KZ-41 prevents retinal endothelial cell apoptosis without inhibiting retinoblastoma cell death through p38 signaling. Invest Ophthalmol Vis Sci. 2013 Sep 3;54(9):5937-43. doi: 10.1167/iovs.13-12326. PubMed PMID: 23942968; PubMed Central PMCID: PMC3762329.
  • Jiang Y, Liu L, Pagadala J, Miller DD, Steinle JJ. Compound 49b protects against blast-induced retinal injury. J Neuroinflammation. 2013 Jul 30;10(1):96. doi: 10.1186/1742-2094-10-96. PubMed PMID: 23899290; PubMed Central PMCID: PMC3751549.
  • Jiang Y, Zhang Q, Liu L, Tang J, Kern TS, Steinle JJ. β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. PLoS One. 2013 Jul 24;8(7):e70555. doi: 10.1371/journal.pone.0070555. Print 2013. PubMed PMID: 23894672; PubMed Central PMCID: PMC3722144.
  • Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ. IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis. Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5376-84. doi: 10.1167/iovs.13-12497. PubMed PMID: 23868984; PubMed Central PMCID: PMC3741024.

View more references (pubmed link)