Edward Chaum, M.D., Ph.D.

Edward Chaum, M.D., Ph.D.

Acting Director of Research

Plough Foundation Professor of Retinal Diseases
Hamilton Eye Institute
Department of Ophthalmology

Department of Pediatrics
Department of Anatomy and Neurobiology
Department of Biomedical Engineering

The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Avenue, Suite 731
Memphis, TN 38163
Tel: (901) 448-5975
Email: Edward Chaum



  • Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
  • M.D. Institution: Cornell University Medical College


Ophthalmology - Edward Chaum

Research Interests

The focus of the basic science research program in our laboratory is in five major areas:

  • Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
  • Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
  • Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
  • Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
  • Tele-ophthalmology and automated diagnostics

Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:

  • Genomic analysis of RPE gene expression,
  • The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
  • The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
  • Electrochemical quantification of blood metabolites and drugs, and
  • Nanotechnology applications in retinal surgery, and
  • Clinical research studies.

Representative Publications

  • Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group, Natarajan R. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9. PubMed PMID: 27162351.
  • Chaum E, Huddleston S, Mastellone J. Nasal Hemiretinal Vein Occlusion. Ophthalmology. 2016 Feb;123(2):399. doi: 10.1016/j.ophtha.2015.12.013. PubMed PMID: 26802710.
  • Myers MH, Li Y, Kivlehan F, Lindner E, Chaum E. A Feedback Control Approach to Organic Drug Infusions Using Electrochemical Measurement. IEEE Trans Biomed Eng. 2016 Mar;63(3):506-11. doi: 10.1109/TBME.2015.2464771. Epub 2015 Aug 5. PubMed PMID: 26258937.
  • Eny KM, Orchard TJ, Miller RG, Maynard J, Grant DM, Costacou T, Cleary PA, Braffett BH, Paterson AD; DCCT/EDIC Research Group. Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes. Diabetes Technol Ther. 2015 Oct;17(10):726-34. doi: 10.1089/dia.2015.0017. Epub 2015 Jul 20. PubMed PMID: 26192006; PubMed Central PMCID: PMC4575521.
  • Chaum E, Winborn CS, Bhattacharya S. Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. Mamm Genome. 2015 Jun;26(5-6):210-21. doi: 10.1007/s00335-015-9568-9. Epub 2015 May 12. PubMed PMID: 25963977; PubMed Central PMCID: PMC4450138.
  • DCCT/EDIC Research Group, Aiello LP, Sun W, Das A, Gangaputra S, Kiss S, Klein R, Cleary PA, Lachin JM, Nathan DM. Intensive diabetes therapy and ocular surgery in type 1 diabetes. N Engl J Med. 2015 Apr 30;372(18):1722-33. doi: 10.1056/NEJMoa1409463. PubMed PMID: 25923552; PubMed Central PMCID: PMC4465212.

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