Dominic M. Desiderio, Ph.D.

Dominic M. Desiderio, Ph.D.

Professor
Department of Neurology


The University of Tennessee Health Science Center
847 Monroe Avenue
Memphis, TN 38163
Tel: (901) 448-5488
Fax: (901) 448-7842
Lab: 117 Johnson Building
Email: Dominic M. Desiderio



Education

  • Ph.D. Institution: Massachusetts Institute of Technology, Department of Chemistry

Research Interests

The hypothesis for this study is that differentially expressed nitroproteins (DENPÖs) exist between human pituitary controls and adenomas. We base our hypothesis on our recent discovery of sixteen 3-nitrotyrosine-containing proteins (3NT proteins; nitroproteins) and several nitroprotein:protein complexes in human pituitaries. Biomarker DENPÖs provide a window into oxidative stress, reactive nitrogen species (RNS), reactive oxygen species (ROS), free radicals, and tumorigenesis. We focus on brain tumors, and specifically on pituitary adenomas. The molecular mechanisms that participate in the formation of non-secreting macroadenomas are largely unknown; more is known about hormone-secreting microadenomas.

Although reversible and non-reversible protein modifications occur, we focus on a chemically stable end-product biomarker, 3-nitro tyrosine (3NT). We analyze nitroproteins in human pituitary tissues (post-mortem controls; post-surgical adenomas) to identify DENPÖs. Those biomarker DENPÖs will clarify molecular events that occur in brain tumors and pituitary adenomas. Those results are readily translatable to other cancer studies.

We have extensive preliminary data on human pituitaries from collaborations with our neurosurgeon colleagues J. T. Robertson, M.D. (University of Tennessee) and Nelson M. Oyesiku, M.D. (Emory University). We have published the quantitation of neuropeptides (controls; adenomas), comparative proteomics to discover differentially expressed proteins (DEPÖs), qualitative phosphoproteomics to discover phosphoproteins, and qualitative nitroproteomics to discover nitroproteins. We have compared our DEPÖs with differential genes.

Representative Publications

  • Grech G, Zhan X, Yoo BC, Bubnov R, Hagan S, Danesi R, Vittadini G, Desiderio DM. EPMA position paper in cancer: current overview and future perspectives. EPMA J. 2015 Apr 15;6(1):9. doi: 10.1186/s13167-015-0030-6. eCollection 2015. PubMed PMID: 25908947; PubMed Central PMCID: PMC4407842.
  • Zhan X, Wang X, Long Y, Desiderio DM. Heterogeneity analysis of the proteomes in clinically nonfunctional pituitary adenomas. BMC Med Genomics. 2014 Dec 24;7:69. doi: 10.1186/s12920-014-0069-6. PubMed PMID: 25539738; PubMed Central PMCID: PMC4302698.
  • Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang do W, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933-9. doi: 10.1093/bioinformatics/btu741. Epub 2014 Nov 10. PubMed PMID: 25388151; PubMed Central PMCID: PMC4375401.
  • Heck A, Desiderio DM, Uggerud E, Lebrilla C, Vouros P. Obituary. Mass Spectrom Rev. 2014 Nov-Dec;33(6):415-6. doi: 10.1002/mas.21446. Epub 2014 Sep 29. Erratum in: Mass Spectrom Rev. 2015 Jan-Feb;34(1):1. PubMed PMID: 25267091.
  • Zhan X, Desiderio DM, Wang X, Zhan X, Guo T, Li M, Peng F, Chen X, Yang H, Zhang P, Li X, Chen Z. Identification of the proteomic variations of invasive relative to non-invasive non-functional pituitary adenomas. Electrophoresis. 2014 Aug;35(15):2184-94. doi: 10.1002/elps.201300590. PubMed PMID: 24729304.
  • Dwivedi N, Neeli I, Schall N, Wan H, Desiderio DM, Csernok E, Thompson PR, Dali H, Briand JP, Muller S, Radic M. Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity. FASEB J. 2014 Jul;28(7):2840-51. doi: 10.1096/fj.13-247254. Epub 2014 Mar 26. PubMed PMID: 24671707.

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