Alessandro Iannaccone, M.D., M.S.

Alessandro Iannaccone, M.D., M.S.

Retinal Degeneration & Ophthalmic Genetics Service
Lions Visual Function Diagnostic Lab

Associate Professor
Department of Ophthalmology
The University of Tennessee Health Science Center

The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Ave, Suite 731 (academic)
930 Madison Ave, Suite 400 (clinical)
Memphis, TN 38163 (USA)
Phone: (901) 448-7831 (academic)
(901) 448-6445/6185 (lab)
(901) 448-1241 (UTMG front desk)
Fax: (901) 448-5028 (UT)/1021 (UTMG)
Email: Alessandro Iannaccone


  • M.D. Institution: University La Sapienza, School of Medicine, Rome, Italy
  • M.S. Institution: (Epidemiology) College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN
  • Postdoctoral: (Medical Retina Research) Scheie Eye Institute, University of Pennsylvania, Philadelphia; (Pediatric Retinal and Optic Nerve Diseases) University of Tennessee Health Science Center, Memphis
  • Residency: School of Ophthalmology, Institute of Ophthalmology, University of Rome, Italy


Research Interests

Presently, stronger emphasis in my research is on 1) inflammatory and autoimmune aspects of age related macular degeneration and panretinal retinopathies; 2) hereditary retinal diseases such as X-linked and dominant retinitis pigmentosa (RP), Leber's congenital amaurosis, Usher syndrome (RP with hearing loss) and Bardet-Biedl syndrome (RP with obesity, polydactyly, and other systemic manifestations); and 3) nutritional influences on macular function and macular pigment.

Recent Publications

  • Lucariello A, Perna A, Sellitto C, Baldi A, Iannaccone A, Cobellis L, De Luca A, De Falco M. Modulation of wolframin expression in human placenta during pregnancy: comparison among physiological and pathological states. Biomed Res Int. 2014;2014:985478. doi: 10.1155/2014/985478. Epub 2014 Jan 23. PubMed PMID: 24588001; PubMed Central PMCID: PMC3920918.
  • Jackson GR, Scott IU, Kim IK, Quillen DA, Iannaccone A, Edwards JG. Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014 Mar 10;55(3):1427-31. doi: 10.1167/iovs.13-13745. PubMed PMID: 24550363; PubMed Central PMCID: PMC3954002.
  • Vishwanathan R, Iannaccone A, Scott TM, Kritchevsky SB, Jennings BJ, Carboni G, Forma G, Satterfield S, Harris T, Johnson KC, Schalch W, Renzi LM, Rosano C, Johnson EJ. Macular pigment optical density is related to cognitive function in older people. Age Ageing. 2014 Mar;43(2):271-5. doi: 10.1093/ageing/aft210. Epub 2014 Jan 15. PubMed PMID: 24435852; PubMed Central PMCID: PMC3927776.
  • Roma C, Esposito C, Rachiglio AM, Pasquale R, Iannaccone A, Chicchinelli N, Franco R, Mancini R, Pisconti S, De Luca A, Botti G, Morabito A, Normanno N. Detection of EGFR mutations by TaqMan mutation detection assays powered by competitive allele-specific TaqMan PCR technology. Biomed Res Int. 2013;2013:385087. doi: 10.1155/2013/385087. Epub 2013 Dec 1. PubMed PMID: 24364033; PubMed Central PMCID: PMC3864078.
  • Branham K, Othman M, Brumm M, Karoukis AJ, Atmaca-Sonmez P, Yashar BM, Schwartz SB, Stover NB, Trzupek K, Wheaton D, Jennings B, Ciccarelli ML, Jayasundera KT, Lewis RA, Birch D, Bennett J, Sieving PA, Andreasson S, Duncan JL, Fishman GA, Iannaccone A, Weleber RG, Jacobson SG, Heckenlively JR, Swaroop A. Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8232-7. doi: 10.1167/iovs.12-11025. PubMed PMID: 23150612; PubMed Central PMCID: PMC3522443.
  • Cox KF, Kerr NC, Kedrov M, Nishimura D, Jennings BJ, Stone EM, Sheffield VC, Iannaccone A. Phenotypic expression of Bardet-Biedl syndrome in patients homozygous for the common M390R mutation in the BBS1 gene. Vision Res. 2012 Dec 15;75:77-87. doi: 10.1016/j.visres.2012.08.005. Epub 2012 Aug 24. PubMed PMID: 22940089.

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