Sangmin Lee, Ph.D.

Sangmin Lee, Ph.D.

Instructor, Department of Neurology


Education

  • B.S. -Hanyang University, Department of Biochemistry, 1989
  • M.S. - Hanyang University, Department of Biochemistry, 1992
  • Ph.D - Hanyang University, Department of Biochemistry and Molecular Biology, 2000

Post-Graduate Training

  • Post-doctorial Fellow - University of Tennessee at Memphis, TN, Department of Neurology, 2000

Professional Experience

  • Lecturer - Hanyang University, 1998
    Department of Biochemistry and Molecular Biology, Korea
  • Director - Nucleogen Co., LTD., Korea, 2000
  • Technical adviser - Nongshim Co., LTD., Korea, 2000
  • Instructor - University of Tennessee at Memphis, TN, Department of Neurology, 2003

Technical Expertise

Cell culture, Protein purification, Gene cloning, Antibody production, GMO screening, Natural antibiotics screening and Proteomics.

Research Interests

A fundamental question concerning autoimmunity is the relationship between infection and the development of disease. One hypothesis that couples infection with autoimmune disease is molecular mimicry. Specifically, we study how patients infected with HTLV-1 (human T-lymphotropic virus type I) develop HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Current my research interest focus on two major areas : 1) Examine immune mechanisms by which viral infection causes neurological disease in an animal model of molecular mimicry. 2) Determine the neuropathological consequences of molecular mimicry.

Representative Publications

Books, Book Chapters, etc.

Lee SM, Morcos Y, Jang H, Stuart JM. Levin MC. HTLV-1 induced molecular mimicry in neurologic disease. Curr Top Microbiol Immunol. 296:125-36, 2005.

Peer Reviewed Journal Articles

Lee SM, Dunnavant FD, Jang H, Zunt J, Levin MC. Autoantibodies that recognize functional domains of hnRNPA1 implicate molecular mimicry in the pathogenesis of neurological disease. Neurosci Lett., 401(1-2):188-93, 2006.

Levin MC, Lee SM, Morcos Y. Autoimmunity to heterogeneous nuclear ribonucleoproteins in neurologic disease, Annals of Neurology, 57(6), 931-32, 2005.

Kim SY, Chudapongse N, Lee SM, Levin MC. Oh JT, Park HJ, Ho IK. Proteomic analysis of phosphotyrosyl proteins in morphine dependent rat brains. Molecular Brain Research, 133(1):58-70, 2005.

Kim SY, Chudapongse N, Lee SM, Levin MC, Oh JT, Park HJ, Ho IK. Proteomic analysis of phosphotyrosyl proteins in the rat brain: effect of butorphanol dependence. J of Neuroscience Research, 77:867-77, 2004.

Kalume F, Lee SM, Morcos Y, Callaway JC, Levin MC. Molecular mimicry in neurological disease: cross-reactive antibodies from patients with immune mediated neurological disease inhibit neuronal firing. J of Neuroscience Research 77:82-89, 2004.

Morcos Y, Lee SM, Levin MC. A role for hypertrophic astrocytes and astrocytes precursors in a case of rapidly progressive multiple sclerosis. Multiple Sclerosis 9:332-341, 2003.

Jernigan M, Morcos Y, Lee SM, Dohan Jr. FC, Raine C, Levin MC. IgG deposition in brain correlates with clincopathological damage in neurological disease. Neurology 60:1320-26, 2003.

Levin MC, Brady J, Lee SM, Morcos Y, Stuart J. Cross reactivity between immunodominant HTLV-1-tax and neurons: implications for molecular mimicry. J of Infectious Diseases, 186:1514-7, 2002.

Levin MC, Lee SM, Kalume F, Morcos Y, Dohan Jr FC, Hasty KA, Callaway JC, Zunt J, Desiderio D, Stuart J. Auto-immunity due to molecular mimicy as a cause of neurological disease. Nature Medicine 8(5):509-513, 2002.

Poster presentations

S. Lee, Y. Morcos, H. Jang and M.C. Levin, "Epitope mapping of recombinant hnRNP A1 protein by HAM/TSP polyclonal antibodies - implications for molecular mimicry." The 35nd Annual meeting of the Neuroscience society, Washington DC, November 2005

M.C. Levin, H. Jang, J.L. Marler and S. Lee, "Peroxiredoxin 1 identified as an autoantigen in HAM/TSP by proteomic analysis." The 35nd Annual meeting of the Neuroscience society, Washington DC, November 2005

S. Lee, Y. Morcos, H. Jang and M.C. Levin, "Novel heterogeneous nuclear ribo- nucleoprotein A1 sequences derived from human neurons identified as autoantigens" The 34nd Annual meeting of the Neuroscience society, Sandiego, November 2004

S.Y. Kim, N. Chudapongse, S.M. Lee, M.C. Levin and I.K. Ho, "Proteomic analysis of phosphotyrosyl proteins in the frontal cortex of butorphanol-dependent rats" Experimental Biology, Washington D.C., May 2004

S.Y. Kim, N. Chudapongse, S.M. Lee, M.C. Levin, I.K. Ho, "Proteomic analysis of frontal cortex of the brain in opioid-dependent rats" 33rd Neuroscience Meeting, New Orleans, November 2003

Kim SY, Chudapongse N, Lee SM, Levin MC, Law PY, Loh HH and Ho IK. "Agonist-specific phosphorylation of an epitope-tagged mu-opioid receptor expressed in Neuro2A cells" The Annual meeting of Experimental Biology, SanDiego, April 2003

Levin MC, Lee SM, Kalume F, Morcos Y, Dohan Jr FC, Hasty KA, Callaway JC, Zunt J, Desterio D and Stuart J. "Molecular mimicry as a cause of neurological disease" Paper presented to: American Neurological Assoc. (New York, October 2002)

Levin MC, Lee SM, Kalume F, Morcos Y, Dohan Jr FC, Callaway JC and Stuart J "Molecular mimicry to neurons results in neurological disease" The 32nd Annual meeting of the Neuroscience society, Orlando, November 2002

Morcos Y, Lee SM and Levin MC " Reactive astrocytes in chronic prograssive multiple sclerosis are involved in lesion development and expansion." The 32nd Annual meeting of the Neuroscience society, Orlando, November 2002

Sang Min Lee, Jung Eun Park, Min Young Kong, Key Seung Cho and Hyo Joon Kim. "Cloning and Purification of Human Adenylate Kinase Isozymes." The Annual Meeting of the Biochemical Society of the Republic of Korea, May 2000.

Sang Min Lee, Sang Ho Lee, Won Jin Lee, Key Seung Cho and Hyo Joon Kim "Studies on the Tissue-specific Expression of Human Adenylate Kinase and its Clinical Applications for the Markers of Myocardial Injury." The Annual Meeting of the Biochemical Society of the Republic of Korea, May 2000.

Sang Min Lee, Jung Eun Park, Sang Ho Lee, Key Seung Cho, Hyo Joon Kim and Young Sik Kim "Cloning and Purification of Heparanase from Human Lymphocyte." The Annual Meeting of the Biochemical Society of the Republic of Korea, May 2000.

Sang Min Lee, Young Tae Koo, Sang Ho Lee, Yong Chan Kim and Key Seung Cho "Development and Application of a Selective Detection Method for Genetically Modified Soybean." The Annual Meeting of the Biochemical Society of the Republic of Korea, May 2000.

Contact Us

Department of Neurology

415 Link Building
855 Monroe Avenue
Memphis, Tennessee 38163
Phone: (901) 448-6199
Fax: (901) 448-7440

David M. Stern, M.D.
Executive Dean

Andrei V. Alexandrov, M.D.
Chairman, Department of Neurology
Semmes-Murphey Professor
aalexa30@uthsc.edu