Mark S. LeDoux, M.D., Ph.D.

Mark S. LeDoux, M.D., Ph.D.

Professor, Department of Neurology
Professor, Anatomy and Neurobiology
Director, Dystonia and Huntington Disease Clinics
Director, Movement Disorders Research Laboratories


Education

  • B.S. - University of Louisiana, Lafayette, 1983
  • M.D. - Louisiana State University School of Medicine, 1988
  • Ph.D. - University of Alabama at Birmingham, 1995

Post-Graduate Training

  • Fellow - Neuroanatomy/Neurophysiology, L.S.U. School of Medicine, 1985-1986
  • Intern - General Surgery, University of Alabama at Birmingham, 1988-1989
  • Resident - Neurosurgery, University of Alabama at Birmingham, 1989-1992
  • Cushing Fellow - American Association of Neurological Surgeons, 1992-1993
  • Resident - Neurology, University of Tennessee College of Medicine, 1995-1997

Professional Certification & Licensing

  • Alabama, 1989
  • Tennessee, 1995
  • Diplomate-American Board of Psychiatry and Neurology

Clinical Subspecialty Expertise

Adult and Pediatric Movement Disorders, Botulinum Toxin for Dystonia and Spasticity

Research Interests

  • Genetics and pathobiology of primary dystonia
    • Using vertebrate and invertebrate models, human lymphoblastoid cell lines and stable transfected cell lines, we study the cellular and systems biology of dystonia-associated proteins (torsinA, THAP1, caytaxin, carbonic anhydrase 8 and epsilon-sarcoglycan).
    • Genetic contributions to late-onset primary dystonia are being examined with candidate gene, genome-wide and gene expression studies.
  • Mechanisms of neurodegeneration in Parkinson disease: several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson disease. To examine the potential role of TIQs in monoaminergic cell death, we have used enantiomeric-selective high-performance liquid chromatography with electrochemical detection, liquid chromatography with tandem mass spectroscopy, cell culture studies of neurotoxicity and assays of mitochondrial membrane potential.
  • Clinical trials of therapeutic interventions for movement disorders (dystonia, Huntington disease, Parkinson disease, restless legs syndrome)
  • Anatomy and computational organization of motor systems
    • The neural networks mediating suprasegmental control of the blink reflex and spontaneous blinking remain poorly understood. Viral transneuronal tracing is being used to define the integrated premotor cortical and subcortical control of levator palpebrae and orbicularis oculi motoneuron activity.
    • In isolation or via interactions with striatal-thalamo-cortical pathways, olivocerebellar structures play a critical role in disorders of motor control such as ataxia and dystonia. Using neurophysiological and molecular tools, we are dissecting the relative roles of individual network elements in the positive and negative signs characteristic of individual movement disorders.

Representative Publications

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Contact Us

Department of Neurology

415 Link Building
855 Monroe Avenue
Memphis, Tennessee 38163
Phone: (901) 448-6199
Fax: (901) 448-7440

David M. Stern, M.D.
Executive Dean

Andrei V. Alexandrov, M.D.
Chairman, Department of Neurology
Semmes-Murphey Professor
aalexa30@uthsc.edu