Susan E. Senogles, Ph.D.
858 Madison Ave.
301 I Molecular Science Building
Memphis, TN 38163
The D2 Dopamine receptors exist in two isoforms the D2 short and D2 long, which differ only by an insert region of 29 amino acids in the third cytoplasmic loop. As determined initially by my laboratory, the two receptors differ in their specificity of coupling to the Gi family of G proteins. My laboratory is investigating which receptor residues are important for selectivity of G protein coupling as well as the residues important for receptor-mediated activation of G proteins. As well, my laboratory is studying the pathway of D2 Dopamine receptor mediated inhibition of growth. The signaling pathway which leads to the antiproliferative effects of the D2 Dopamine receptor appears to involve activation of Phospholipase D and and Arachidonic Acid release. We are currently investigating this signaling pathway using Small Cell Lung Cancer cell lines, which endogenously express the D2 Dopamine receptor. A third project involves the elucidation of the signaling pathway for the D3 Dopamine receptor. A number of anti-Parkinson drugs are D3 dopamine receptor agonists, and we are focused on elucidating the signaling pathway used by this receptor to mediate a neuroprotective response.
- B.S. Biochemistry from University of Minnesota, Twin Cities Campus, 1973-1977
- Ph.D. Biochemistry/Biophysical Biochemistry from University of Minnesota, Twin Cites, 1980-1984
- Post-Doctoral Fellow at Dept. of Cell Biology, Duke University, 1985-1989.