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Distinguished Lecture Series

"The Ubiquitin Proteolytic System: From Basic Mechanisms Thru Human Diseases and on to Drug Targeting" presented by Dr. Aaron Ciechanover

The University of Tennessee Health Science Center’s Office of Research is honored to welcome Dr. Aaron Ciechanover to Memphis for the first time. Dr. Ciechanover is an Israeli Biochemist who won the Nobel Prize in Chemistry “for the discovery of the ubiquitin-mediated protein degradation” in 2004. Together with Avram Hershko of the Technion- Israel Institute of Technology and American biologist Irwin Rose, the trio were awarded for characterizing the process in our cells which allows for the degradation and recycling of proteins using ubiquitin. His discoveries have opened up opportunities in drug discovery, and in the diagnostics and treatment for a range of disorders, from cancer to neurodegeneration. 

On January 16, 2018, Dr. Ciechanover will deliver a scientific talk on "The Ubiquitin Proteolytic System: From Basic Mechanisms Thru Human Diseases and on to Drug Targeting" from Noon to 1PM in the College of Pharmacy Building (881 Madison Ave.), Room 101. Several alternative viewing rooms have been reserved on UTHSC's campus as well including the College of Pharmacy Building, Rooms 102, 118/119, and the Freeman Auditorium (930 Madision Avenue, 3rd Floor).

UTHSC is honored to host one of the world’s leading experts in the field of biochemistry and we invite you to learn from Dr. Ciechanover alongside us. More details regarding Dr. Ciechanover’s talk will be given in the upcoming days.

About Dr. Ciechanover

Aaron Ciechanover was born in Haifa, Israel in 1947. He is currently a Distinguished Research Professor in the Faculty of medicine at the Technion- Israel Institute of Technology in Haifa, Israel. He received his MSc (1971) and MD (1973) from the Hebrew University in Jerusalem. He then completed his national service (1973-1976) as military physician, and continued his studies to obtain a doctorate in biological sciences in the Faculty of Medicine in the Technion (DSc; 1982). There, as a graduate student with Dr. Avram Hershko and in collaboration with Dr. Irwin A. Rose from the Fox Chase Cancer Center in Philadelphia, USA, they discovered that covalent attachment of ubiquitin to a target protein signals it for degradation. They deciphered the mechanism of conjugation, described the general proteolytic functions of the system, and proposed a model according to which this modification serves as a recognition signal for a specific downstream protease. As a post-doctoral fellow with Dr. Harvey Lodish at the MIT, he continued his studies on the ubiquitin system and made additional important discoveries. 

Along the years it has become clear that ubiquitin-mediated proteolysis plays major roles in numerous cellular processes, and aberrations in the system underlie the pathogenetic mechanisms of many diseases, among them certain malignancies and neurodegenerative disorders. Consequently, the system has become an important platform for drug development. Among the numerous prizes Ciechanover received are the 2000 Albert Lasker Award, the 2003 Israel Prize, and the 2004 Nobel Prize (Chemistry; shared with Drs. Hershko and Rose). Among many academies, Ciechanover is member of the Israeli National Academy of Sciences and Humanities, The European Molecular Biology Organization (EMBO), the American Academy of Arts and Sciences (Foreign Fellow), the American Philosophical Society, the National Academies of Sciences (NAS) and Medicine (NAM) of the USA (Foreign Associate), the Pontifical Academy of Sciences at the Vatican, the Chinese Academy of Sciences (CAS; Foreign Member), the Russian Academy of Sciences (Foreign Member), and the German Academy of Sciences (Leopoldina).


Date: Tuesday, January 16, 2018
Time: 12 to 1 pm
Location: College of Pharmacy Building, Room 101 (881 Madison Avenue)*
*Alternative Locations: College of Pharmacy Building, Rooms 102, 118/119, and the Freeman Auditorium (930 Madison Avenue, 3rd Floor)

Light refreshments will be served

Parking Information: Attendees may park in the Memphis Bioworks Foundation Parking garage located at the corner of Dudley Street and Union Avenue during Dr. Ciechanover's talk. The parking garage entrance is off of Dudley Street directly across from TriMetis. Please enter via the "Permit" or "Reserved Parking" driveways. You may park anywhere in the garage. Once parked, please exit the garage walking North toward Madison Avenue and follow the signage to the College of Pharmacy Building or the Freeman Auditorium.

Please see the directional map for reference.

Last Published: Dec 14, 2017