874 Union Avenue
Crowe Building Room 5P
Memphis, TN 38163
Tel: (901) 448-4135
Fax: (901) 448-6940
Current Office Hours
Charles R. Yates, Pharm.D., Ph.D.
- Pharm.D. (Pharmacy), The University of Tennessee, College of Pharmacy
- Ph.D., (Pharmaceutics), The University of Tennessee, College of Graduate Health Sciences
Dr. Yates' research is focused on the pharmacokinetics and pharmacodynamics of drugs used in the critically ill patient. A special emphasis is placed on elucidating the underlying mechanisms contributing to inter-individual variability in drug response (e.g., pharmacogenetics of drug metabolizing enzymes, disease progression, etc.). It is well appreciated that inflammation alters the disposition of drugs by affecting renal and hepatic clearance, as well as, protein binding of drugs. A better understanding of the mechanism(s) by which inflammation alters drug disposition will lead to more effective pharmacotherapy.
Dr. Yates' research group is actively collaborating with researchers and clinicians from the Memphis Lung Research Program and The University of Tennessee, Health Science Center Transplant Program (transplant.uthsc.edu).
- Reactor Controls Technician, USS Daniel Boone, Submarine Overhaul Facility, Newport News Naval Shipyard, Newport News, Virginia, 1986-1987.
- Reactor Controls Technician, USS Daniel Boone, United States Navy Group Six Submarine Force, Charleston Naval Base, Charleston, South Carolina, 1987-1988.
- Instructor, USS Samuel Rayburn, Nuclear Power Training Unit, Naval Weapons Station, Goose Creek, South Carolina, 1988-1991.
- Graduate Teaching and Research Associate, The University of Tennessee, Department of Pharmaceutical Sciences, Memphis, TN 38163, 1993-2000.
- Poison Information Specialist, Southern Poison Center, The University of Tennessee Health Science Center, TN 38163, 1999-2000.
- Assistant Professor, The University of Tennessee, Department of Pharmaceutical Sciences, Memphis, TN 38163, 2000-present.
HONORS AND AWARDS
- The University of Tennessee Alumni First Year Scholarship, 1993.
- Ralph R. Braund Young Investigator Award, 1997.
- Rho Chi Schering Plough American Foundation of Pharmaceutical Education First Year Graduate Scholarship, 1997.
- Fellow of the American Foundation of Pharmaceutical Education, 1998-2000.
- Feurt Scholar, The University of Tennessee, 1999.
- Van Vleet Scholar, The University of Tennessee, 2000.
- Mukherjee A, Kirkovsky L, Yao X-T, Yates CR, Miller DD, Dalton JT: Enantioselective binding of Casodex to the androgen receptor. Xenobiotica 1996 26(2):117-122.
- Tai H-L, Krynetski EY, Krynetskaia NF, Yates CR, Evans WE: Genetic basis for thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele (TPMT*3) in Caucasians. American Journal of Human Genetics 1996 58:694-702.
- Krynetski EY, Tai H-L, Yates CR, Fessing M, Loennchen T, Schutz JD, Relling MV, and Evans WE: Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. Pharmacogenetics 1996 6:279-280.