Current Meibohm Lab Members


Graduate Students

Nageshwar R Budha in lab

Nageshwar R Budha

874 Union Ave
Suite 105p, Crowe Research bldg
University of Tennessee Health Science Center
Memphis, TN-38163
Email: nbudha@uthsc.edu
Phone: 901-448-6274 (Lab)

Education

  • Graduate School: University of Tennessee 2004 - present
  • M.Pharm (Pharmaceutics): University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
  • B.Pharm: University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India

Teaching Experience

  • 2005 - present : Graduate teaching assistant - Pharmacokinetics & Dose optimization

Professional Affiliations

  • Rho Chi Scholastic Pharmacy Honor Society, Alpha Nu Chapter - inducted 02/06
  • American College of Clinical Pharmacology (ACCP) - joined 01/05
  • American Association of Pharmaceutical Scientists (AAPS) - joined 08/2004

Awards & Honors

  • Podium presentation finalist - South East Regional Interdisciplinary Symposium (SERIS) - 2006
  • Inducted into Rho Chi Scholastic National Pharmacy Honor Society, Alpha Nu Chapter - 2006
  • First Rank in M.Pharm (Pharmaceutics) - Kakatiya University, Warangal, India - 2004
  • Junior Research Fellowship - All India Council for Technical Education (AICTE) - 2002-2004
  • Indian Drug Manufacturers Association (IDMA) - G P Nair Award - 2002
  • Indian Pharmaceutical Association (IPA) - Gold Medal - 2002
  • University First Rank in B.Pharm - Kakatiya University, Warangal, India - 2001
  • All India 2nd Rank in GATE-2001 (99.92 percentile score) in Pharmaceutical Sciences - 2001

Yi Zhang

874 Union Ave
Suite 4.5p, Crowe Research bldg
University of Tennessee Health Science Center
Memphis, TN-38163
Phone: 901-448-3385 (Lab)

Education

  • M.D Tianjin Medical University, China

Professional Experience

  • Graduate Student: Department of Pharmaceutical Sciences, UTHSC
  • Senior Research Assistant: Department of Pharmaceutical Sciences
  • Physician: Department of Tianjin Medical University Hospital, China

Publications and Abstracts

  1. Shen Li, Yi Zhang, Les Stuart, Steven Gurley, Bob M Moore, and Charles R Yates. The novel phenyl-substituted cannabinoid KM-233 protects against lipopolysaccharide induced lung neutrophil infiltration and vascular injury. The AAPS Journal. 2005; 7(S2): Abstract T2097.
  2. Shen Li, Les Stuart, Yi Zhang, Himanshu Bhattacharjee, Mathangi Krishnamurthy, Bob M Moore, Charles R Yates. The novel phenyl-substituted cannabinoid KM-233 protects endotoxin induced acute lung injury. (podium presentation at the PharmForum 2005 meeting, Oxford, MS, May 2005).
  3. Shuzhi Feng, Yi Zhang, and Jie Luo. A case of non-Hodgkin lymphoma was misdiagnosed as tuberculous pleuritis. (admitted)
  4. Guangming Zhang, and Yi Zhang. A study of the multidrug resistance (MDR1) gene and the multidrug resistance associated protein (MRP) gene expression in gastric carcinoma. Tianjin Medical Journal. 2002, July, Vol.30: 23-24.
  5. Jianli Tian, Hui Wang, Wen Sun, and Yi Zhang. A multidimensional evaluation of psychosomatic health status of the elderly in Tianjin. Chin J Geriatri. 2002, Jun, Vol.21, No.3: 222-223.
  6. Shuzhi Feng, Yi Zhang, Wen Sun, et al. The changes of lipids and plasma homocysteine in aged patients with isolated systolic hypertension. Journal of Tianjin Medical University. 2001 Vol.7 No.3: 406-408.
  7. Shuzhi Feng, Yi Zhang, Wen Sun, and Meishu Ren. The initial study of the platelet activated function and hemorheology in the aged patients with malignant tumor. Chinese Practical New Medicine. 2001, Vol.3, No.11: 968-969.
  8. Yi Zhang, and Shuzhi Feng. Hiatal hernias in the elderly misdiagnosed to be coronary heart disease: 3 cases report. Tianjin Medical Journal. 2000, Vol.28, No.3: 186-187.

Post Doctoral Trainees

Nitin Mehrotra

874 Union Ave
Suite 4.5p, Crowe Research bldg
University of Tennessee Health Science Center
Memphis, TN-38163
Phone: 901-448-3385 (Lab)

About Dr. Mehrotra

Dr. Nitin Mehrotra graduated in pharmacy from Dr. K.N. MIPER, India in 1999 following which he joined Birla Institute of Technology and Sciences (BITS), Pilani to pursue his Masters in Pharmacy. In 2001, he joined Pharmacokinetics and Metabolism Division, Central Drug Research Institute (CDRI) to work towards his doctoral degree while being affiliated to BITS, Pilani.

He worked in CDRI on various projects involving pharmacokinetics and metabolism studies of potential CDRI candidate drugs using advanced analytical techniques like liquid chromatography-hyphenated mass spectrometry. He also performed pattern profiling (finger printing) of some potent herbal preparations of CDRI. In June 2005, he joined Dr. Meibohms research group, UTHSC. Since then he has assisted in various projects:

  1. Association of various factors with mortality in patients with obstructive airway disease using various survival analysis techniques.
  2. Clinical trial simulation, which is a powerful technique in predicting the power of clinical trial and test various scenarios using simulations.
  3. Pharmacokinetic-pharmacodynamic modeling of a hypolipidaemic drug using mechanism based modeling.

His research interest includes integrating pharmacokinetics and pharmacodynamics using computer based modeling to understand the exposure-response relationship in a quantitative fashion. Population pharmacokinetic analysis, which uses models based on pharmacology, physiology and disease for quantitative analysis of interactions between drugs and patients. Clinical trial simulation to predict the power of clinical trial upfront (utilizing established PK and/or PK-PD model with estimates of variability) by running various ‘what if’ scenarios on virtual populations generated using Monte Carlo simulations. Survival analysis using non-parametric approaches (Kaplan Meier analysis and Cox proportional hazards regression modeling).

Fellowships/Awards

  1. Graduate Aptitude Test in Engineering (GATE) qualified with 97.98 percentile (April 1999) with All India Rank 50.
  2. Junior Research Fellowship (University Grants Commission, India) at BITS, Pilani, Rajasthan (India) during M. Pharm (January 2000-June 2001).
  3. M.Pharm Gold Medalist for the year 2000-2001.
  4. CDRI Research Scholarship (August 2001-February 2004).

Research Technicians

Shailly Mehrotra

874 Union Ave
Suite 4.5p, Crowe Research bldg
University of Tennessee Health Science Center
Memphis, TN-38163
Phone: 901-448-3385 (Lab)

Shailly Mehrotra did her graduation in Pharmacy from Delhi College of Pharmacy, India. She worked for Dabur Research Foundation in area of Novel Drug Delivery Systems before joining UTHSC. Her responsibilities as a research assistant include performing various molecular biology techniques with main emphasis on isolation of RNA, DNA from clinical samples and performing real time polymerase chain reaction (RT-PCR) which helps establishing a correlation between various genes, inflammatory markers associated with obstructive lung disease.