Transcranial Magnetic Stimulation (TMS)

TMS is a methodology that is used to study brain function by introducing a localized magnetic fields using coils of wire encased in plastic, and applied on a person’s scalp in a safe and painless manner. TMS is used by itself or as a complement with other neuroimaging methods in the study of motor and cognitive functions. Unlike other imaging methods, only TMS allows the determination the true functional significance of a brain region and the causal relationship between brain activity and behavior. Since its introduction by Barker et al., in 1985, TMS has become a popular tool to study motor and cognitive systems in healthy and clinical populations. TMS is emerging as an important diagnostic tool in investigating limb motor, speech, language, and other cognitive functions in various neurological and psychiatric disorders. In addition, TMS has shown great promise as a therapeutic tool in several neurological and psychiatric disorders. The focus of the TMS laboratory at UTHSC and Le Bonheur Children's Hospital is to enhance the precision and ease with which TMS can be used for the diagnosis and treatment of neurological and psychiatric disorders and for neuroscience research.

The clinical usefulness of TMS demonstrated by numerous studies carried out in the last decade, and its excellent safety record has led the FDA to approve the use of TMS for the following:

  • Pre-surgical motor mapping in children and adults.
  • Pre-surgical speech lateralization in children and adults.
  • Treatment of major depressive disorder that has failed at least one pharmacological treatment in adults.

Personnel

Shalini Narayana, MBBS, PhD -- Assistant Professor, Division of Clinical Neurosciences, Department of Pediatrics, Department of Pediatrics, University of Tennessee College of Medicine, and Neuroscience Institute, Le Bonheur Children's Hospital.

Andrew C. Papanicolaou, PhD -- Professor and Chief, Division of Clinical Neurosciences, Department of Pediatrics, University of Tennessee College of Medicine, and Neuroscience Institute, Le Bonheur Children's Hospital

Roozbeh Rezaie, PhD -- Assistant Professor, Division of Clinical Neurosciences, Department of Pediatrics, Department of Pediatrics, University of Tennessee College of Medicine, and Neuroscience Institute, Le Bonheur Children's Hospital

Samuel Stewart McAfee, BS -- TMS Technician, Neuroscience Institute, Le Bonheur Children's Hospital.

Holly Smith, RN, BSN, CPN -- TMS coordinator, Neuroscience Institute, Le Bonheur Children's Hospital

TMS System Specifications

The division of clinical neurosciences at UT and Le Bonheur uses Nexstim navigated brain stimulation system 4 TMS unit with Nexspeech module (www.nexstim.com).

The NBS System 4 has the following features:

  • Navigation: MRI-guided targeting of E-field
  • Integrated, powerful TMS with precision coils
  • Dual screens for side-by-side display of intracranial E-field and EMG responses
  • DICOM export of images to surgical navigation systems and microscopes
  • Navigated rTMS delivery
  • Proprietary software for clinical ease-of-use
  • Compact and mobile
  • NexSpeech® module (option) for speech mapping that includes:
    • 17" LCD screen for displaying image stack to the patient
    • Video camera for recording speech behavior in baseline and stimulation sessions
    • Main Software for control of image display, audio and video recording of exams and synchronization of rTMS with image display
    • Analyzer Software for comparison of speech performance between the baseline and stimulation sessions
    • For clinical research into applications of repetitive TMS (rTMS), the new NBS System 4 offers one of the most powerful stimulators available. Precision-manufactured therapy coils and accurate navigation allow rTMS protocols to be accurately and reliably targeted to the desired intracranial structures and to be replicated in later sessions with the highest possible precision.

For more information on MEG technology or to make a referral, please call (901) 287-6026 or email Dr. Shalini Narayana, TMS Lab Director, at snaraya2@uthsc.edu.

Contact Us

Clinical Neurosciences
Department of Pediatrics
UTHSC College of Medicine
and
The Neuroscience Institute
Le Bonheur Children's Hospital
777 Washington Ave.
Memphis, TN 38105

Holly Smith, RN, BSN, CPN
MEG Coordinator
901-287-7126 (phone)
901-287-4540 (fax)
Holly.Smith@lebonheur.org