Brain Plasticity, Injury and Stoke

Functional Brain Reorganization in Stroke Recovery (Supported by P01 NS46588-01A2), Andrew C. Papanicolaou, P.I.

The objective of this project was to use MEG study of the effects of aphasia therapy after stroke on brain functioning. In particular, this study sought to understand how therapy for aphasia may change the way the brain functions following the occurrence of a stroke. We examined brain activity prior to and after a period of intense aphasia therapy to determine what impact therapy has on brain function, with a view to designing and evaluating therapies for aphasia.

Mission Connect Mild TBI Translational Research Consortium (Supported by D.O.D Award # W81XWH-08-2-0135), Neuroimaging Project, Andrew C. Papanicolaou, P.I.

The overarching goal of this project is to use MEG to detect and characterize focal abnormalities in neurophysiological function in patients with mTBI and PTSD for the purpose of distinguishing between the two. MEG has been shown to be sensitive to cognitive complaints in patients with mTBI. In addition neurophysiological abnormalities differentiate patients with mTBI and PTSD in some studies. As well as the aforementioned goal, we also propose to explore the relationship between diffusion tensor imaging (DTI) and MEG findings. While MEG provides data regarding focal abnormalities in neural response in the cortex, DTI reveals the status of white matter tracts that form the intracortical connections. Thus, MEG, in combination with DTI, may lead to identification of more distinct, replicable patterns of brain abnormalities in subjects with PTSD and mTBI that may lead to better differentiation between these groups of patients, as well as from patients with a combination of both disorders.