Research Applications of TMS
Expanding a Neural Model of Speech Using Virtual Lesions and Connectivity Studies.
R21 DC 009467-01A1, Shalini Narayana (PI)
The long-range goal of this research program is the development of a system-level model of the human speech-motor system that encompasses normal and disordered speech motor control. The goal of the current proposal is to test portions of the Directions into Velocities of Articulators (DIVA) a model of speech production that has both behavioral and neural components using transcranial magnetic stimulation and multimodal imaging.
Mechanisms of Action of TMS-Induced Performance Enhancement. VA merit award, PT Fox
PI (University of Texas Health Science Center at San Antonio), Shalini Narayana Co-I.
The overall goal of this project is 1) to determine the mechanisms of action of short-term (single stimulation session) TMS-induced performance enhancement. 2) To determine the mechanisms of action of long-term (multiple stimulation sessions) TMS-induced performance enhancement.
Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in Baboons. R21
NS065431 Szabo PI (University of Texas Health Science Center at San Antonio), Shalini
This study is part of an ongoing effort to develop a neurophysiological and neuroimaging model of photosensitive, generalized epilepsy in the baboon. TMS, PET and electrophysiological recordings are being used to develop a comprehensive neural network model of epilepsy.
A Baboon Model of TMS/PET As a Vehicle for Rational Development of TMS Treatments.
R21 NS062254 PT Fox - PI (University of Texas Health Science Center at San Antonio),
Shalini Narayana Co-I.
Ultimately, this work will lead to rational, theoretically grounded development of TMS as a treatment modality and as a tool for quantifying network property changes of TMS and other therapeutic modalities which modify local or network properties of neuronal populations.