Research

Fellows have opportunities to learn and get involved in both clinical and basic science research. They can do research with the faculty inside and outside of the division of neonatology. The research interests of the faculty vary from basic science research in infection/ immunology to cerebral circulation and physiology. Varied clinical science projects are also underway and we have been part of several multicenter trials.

The NICU also has a database for the past 30 years which makes it easy for faculty and fellows to obtain background information for clinical projects.

Selected Recent Publications

  1. Rouse DJ, Hirtz and the Eunice Kennedy Shriver Maternal-fetal Medicine Network Units: A randomized, controlled trial of Magnesium sulfate for the prevention of cerebral palsy, The New England Journal of Medicine, August; 359 (9): 895-905, 2008.
  2. Talati AJ, Kim H-J, Kim YI, Yi AK, English, BK: Role of bacterial DNA in macrophage activation by Group B streptococci, Microbes and Infection,10: 1106-1113, 2008.
  3. Crumby T, Rinehart E, Carby M, Kuhl D, Talati AJ : Evaluation of Vancomycin First Dose Kinetics for Therapy Guidance in the Neonatal Intensive Care Unit, American Journal of Health-System Pharmacy, January; 66: 149-53, 2009.
  4. Weisman L, Thackray H, Steinhorn R, Walsh W, Lassiter H, Dhanireddy R, Brozanski B, et al. A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis in premature infants. Pediatrics. 2011 Aug;128(2):271-9. Epub 2011 Jul 25.
  5. Whitton GB, Dhanireddy R, Jain SK. Effect of prematurity on protein glycosylation in the newborns. Pediatr Int. 2011 Aug;53(4):480-2.
  6. Subramanian S, Mohandes A, Dhanireddy R, Koch M. Association of Bronchopulmonary dysplasia and hypercarbia in ventilated infants with birth weights of 500- 1499 grams. Matern and Child Health J. 2011 Dec;15 Suppl 1:S17-26.
  7. Elabiad MT, MD and Jie Zhang, MD; Pulmonary Pepsinogen C in Gastroesophageal Reflux Disease; Journal of Pediatric Gastroenterology and Nutrition Volume 53, Issue 4, October 2011, Pages 401-403
  8. Elabiad MT, MD and Rebecca Hook, MD; Mercury in Blood Transfusions in Extremely Low Birth Weight Infants; Pediatrics Volume 128, Issue 2, August 2011, Pages 331-334.
  9. Spentzas T, Kudumula R, Acuna C, Talati AJ, Meals EA and English BK: Role of Phenol-Soluble Modulin-alpha and Delta-toxin in Macrophage Activation by Community-Associated, Methicillin-Resistant strains of Staphylococcus aureus . Cell Immunol. (2011). Doi:10.1016/j.cellimm.2011.03.009.
  10. Chilakala SK, Boulden TF, Pourcyrous M. Ruptured remnant of urachal diverticulum: an unusual cause of congenital urinary ascites. Journal of Perinatology, (2012), 1-3.
  11. Goodwin AJ, Reed-Day H, VandeWalle-Ramirez K, Boulden TF, Pourcyrous M. A preterm infant with early Bacteroides Fragilis meningitis and bilateral subdural empyema: Literature review and treatment options. Journal of Neonatal-Perinatal Medicine 5(2012) 1-5.
  12. Jones KL, Pivnick EK, Hines-Dowell S, Weese-Mayer D, Berry-Kravis E, Santiago T, Lasater O, Nnorom C, Pourcyrous M. A triple threat: Infant presents with Down syndrome, congenital central hypoventilation syndrome, and Hirschsprung disease. Pediatrics. Accepted for publication.
  13. Xie Y, Pivnick EK, Cohen HL, Adams-Graves PE, Pourcyrous M, Augun B, Hankins JS. Phenocopy of Warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload. Journal of Pediatric Hematology/Oncology. Accepted.
  14. Rana D, Abughali N, Kumar D, Super DM, Jacobs MR, Kumar ML: Staphylococcus aureus infections including community acquired (CA) MRSA in level III NICU: 2001-2008. American Journal of Perinatology. 2012, 29(6): 401-408.
  15. Talati AJ and Koneru P. Neonates at risk for Congenital Syphilis: Radiographic and Cerebrospinal fluid Evaluations. Southern Medical Journal, 2011, 104 (12) : 827-30.
  16. Hasan M, Pourcyrous MP, Talati AJ. Bacillus cereus meningo-encephalitis with diabetes insipidus in a preterm infant. Accepted for publication in Journal of Neonatal –Perinatal Medicine, October 2011.

Abstracts Presented

  1. Yanamandra K, Aryama JG, Napper D, Pramanik A, Bocchini Jr, JA, Dhanireddy R: Do NOS3 Haplotypes influence cardiopulmonary transition in premature infants? Abstract (control number 20017) accepted for inclusion in the 12th International Congress of Human Genetics. Paper presented (Poster) at the 61st Annual Meeting of the American Society Human Genetics, Montreal, Canada, October 11-15, 2011.
  2. Yanamandra, K, Pourcyrous M, Dhanireddy R. C-reactive Protein Gene Polymorphisms and Neonatal Sepsis. Publication Number 1155.6 Paper (Poster) presented at the 2012 Annual Meeting of Southern Society for Pediatric Research (SSPR), New Orleans, LA, Feb. 2-11, 2012.
  3. Upadhyay K, Dhanireddy R, Pourcyrous M, Talati AJ. Neonates Born after Multiple Gestations at the Edge of Viability – A Review of Mortality and Morbidity over 20 Years. Publication Number 4526.408 Paper (Poster) presented at the 2012 Annual Meeting of Southern Society for Pediatric Research (SSPR), New Orleans, LA, Feb. 2-11, 2012.
  4. Upadhyay K, Dhanireddy R, Talati AJ. A 22 Year Review of Major Congenital Malformations in a Level 3 NICU. Publication Number 4524.317. Paper (Poster) presented at the 2012 Annual Meeting of Southern Society for Pediatric Research (SSPR), New Orleans, LA, Feb. 2-11, 2012.
  5. Dolapo O, Dhanireddy R, Talati AJ. The Demographics and Clinical Characteristics of Staphylococcus Sepsis in a Neonatal Intensive Care Unit – A 10 Year Review. Platform presentation at the 2012 Annual Meeting of Southern Society for Pediatric Research (SSPR), New Orleans, LA, Feb. 2-11, 2012.
  6. Arrindell E, Dhanireddy R, Talati AJ. Admission Hypothermia Reduction and Its Impact on Morbidity. Paper (Poster) presented at the Pediatric Academic Societies Annual Meeting (PAS), Boston, MA, April 28, 2012. EPAS:2920.308.
  7. Dolapo O, Dhanireddy R, Talati AJ. Staphylococcus Sepsis in a Neonatal Intensive care unit – A 10 year review. Paper (Poster) presented at the Pediatric Academic Societies Annual Meeting (PAS), Boston, MA, April 29, 2012. EPAS:1524.390.
  8. Atherton J and Mohamad T. Elabiad, MD, An Algorithm to Reduce the Number of C – Reactive Proteins (CRP) Ordered without Affecting Patient Safety in Newborns, Poster, Fourth Annual Pediatrics Research Day, University of Tennessee Health Science Center, Memphis, Tennessee Oct. 2011.
  9. Mimily Harsono, MD; Ramasubbareddy Dhanireddy, MD; Ajay J. Talati, MD; Mohamad T. Elabiad, MD. Association between Packed Red Blood Cell Transfusions and Necrotizing Enterocolitis in Very Low Birth Weight Infants, American Academy of Pediatrics Perinatal and Developmental Medicine Symposium Marco Island, Florida; Oral presentation; Nov. 2011.
  10. Matano, B.A, Krishnan R, Paul, J.A, Brown M, Hayes MJ. Neurodevelopment and Motor Sequelae in Methadone-Exposed Infants: Synergistic Effects of Alcohol (Abstract #: 754673). Platform presentation, Pediatric Academic Society meeting, Boston, May 2012.
  11. Jones KL, Pivnick EK, Hines-Dowel S, Weese-Mayer D, Berry-Kravis E, Santiago T, Lasater O, Nnorom C, Pourcyrous M. A triple threat: Infant presents with trisomy 21, congenital central hypoventilation syndrome, and Hirschsprung disease. Pediatric Research day. (Poster) Nov 16, 2011. Memphis, TN.
  12. Chilakala S, Pourcyrous M, Parfenova H, Leffler CW. Prolonged hypercapnia and cerebrovascular reactivity in newborn pigs. Pediatric Research day. (Poster) Nov 16, 2011. Memphis, TN.
  13. Chilakala S, Pourcyrous M, Parfenova H, Leffler CW. Prolonged hypercapnia and cerebrovascular reactivity in newborn pigs. Southern Society of Pediatric Research. New Orleans, LA, Feb 2012 (platform). Clinical Research, 2012.
  14. Chilakala S, Pourcyrous M, Parfenova H, Leffler CW. Prolonged hypercapnia and cerebrovascular reactivity in newborn pigs. The Society of Pediatric Research. Boston, Massachusetts, May 2012 (Platform). Pediatric Research. E-PAS 2012.
  15. Harsono M, Parfenova H, Leffler CW, Pourcyrous M. Head cooling protects postictal cerebrovascular function in newborn piglets. The Society of Pediatric Research. Boston, Massachusetts, May 2012 (Platform). Pediatric Research. E-PAS 2012.
  16. Hiregoudar B, Meals E, Talati AJ, English B. Group B streptococci exposed to azithromycin alone or with ampicillin (compared with ampicillin alone) stimulate decreased macrophage tumor necrosis factor secretion. Poster presentation at the AAP annual meeting, Section of Perinatal Pediatrics. October 14, 2011.
  17. Harsono M, Dhanireddy R, Talati AJ, Elabiad MT. Association between Packed Red Blood Cell Transfusions and Necrotizing Enterocolitis in Very Low Birth Weight Infants. Poster presentation at the AAP annual meeting, Section of Perinatal Pediatrics. October 14, 2011.
  18. Arrindell E, Talati AJ. Lactobezoar in a Neonate. Poster presentation at Southern Regional Meetings, New Orleans, February 2012.
  19. Hiregoudar B, Meals E, Talati AJ, English B Azithromycin (AZ) Inhibits Tumor Necrosis Factor (TNF) Secretion by Murine Macrophages Stimulated with AZ-Susceptible or AZ-Resistant Group B Streptococci. Accepted for poster presentation at PAS meetings, April 28, 2012, Boston. EPAS: 1519.33.
  20. Dolapo O, Dhanireddy R, Talati AJ. Staphylococcus sepsis in a Neonatal Intensive care unit- A 10 year review. Accepted for poster presentation at PAS meetings, April 29, 2012, Boston. EPAS:
  21. Smith K, Gruber L, Spence G, Talati AJ. “My life is in your hands” – CLABSI reduction quality improvement project – poster presentation at NICQ7 collaborative meeting in Denver, March 2012.

Contact Information

Division of Neonatal-Perinatal Medicine

For further information please email Dr. Ajay Talati
or Leeanna Fox Irwin

853 Jefferson Ave #201
Memphis, TN 38163
Phone: 901-287-5265