Dr. Andreas Schwingshackl
Assistant Professor of Pediatrics and Physiology,
Associate Fellowship Director
Dr. Schwingshackl received his medical degree from the University of Innsbruck in Innsbruck, Austria, in 1997 and received his Ph.D. in Physiology from the University of Alberta in Edmonton, Canada, in 2003. Dr. Schwingshackl was a Pediatric Resident at St. Joseph Hospital in Phoenix, Arizona, and a Fellow in Pediatric Critical Care Medicine at Mattel Children’s Hospital UCLA in Los Angeles, California, before joining the Critical Care Faculty at UTHSC in July, 2009.
Dr. Schwingshackl’s research interest lies in investigating the role of stretch-activated ion channels (SAC) in inflammatory mediator secretion in the lung. Both, mechanical stretch and hyperoxia appear to induce expression of stretch-activated ion channels (SAC) in the lung. Inhibition of these channels may constitute a novel target to reduce inflammation in the lungs of mechanically ventilated children.
- Schwingshackl, A, Teng, B., Ghosh, M., West, N., Makena, M., Gorantla, V., Sinclair, CE., Waters, CM. Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 302:L93-L102 (2012).
- Schwingshackl, A, Teng, B., Ghosh, M., Lim, KG., Tigyi, G., Narayanan, D., Jaggar, JH., Waters, CM. Regulation of Interleukin-6 Secretion by the Two-Pore-Domain Potassium (K2P) Channel Trek-1 in Alveolar Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. Feb 15;304(4):L276-86 (2013).
- Ghosh, M., Gorantla, V., Makena, P., Luellen, C., Sinclair, SE., Schwingshackl, A, Waters, CM. Insulin like growth factor-1 stimulates differentiation of AT II cells to AT I-like cells through activation of Wnt5a. Am J Physiol Lung Cell Mol Physiol. Aug 1;305(3):L222-8 (2013).
- Schwingshackl, A, Teng, B., Ghosh, M, and Waters, CM. Regulation of Monocyte Chemotactic Protein-1 (MCP-1) Secretion by the Two-Pore-Domain Potassium (K2P) Channel Trek-1 in Human Alveolar Epithelial Cells. Am J Transl Res. Aug 15;5(5):530-42 (2013).
- Philip, R., Schwingshackl, A, Anand, KS., Huang, X., Blakely, D., Velasquez, A., Arevalo, A., and Alpert, B. Inverse Relationship between Cardio-Ankle Vascular Index and Body Mass in Healthy Children. Pediatrics 2013 (submitted).
- Schwingshackl, A, Makena, P, Teng, B., Ghosh, M, Sinclair, SE., Luellen, C., Balasz, L., Bryan, RM., Lloyd, EE., and Waters, CM. Deficiency of the Two-Pore-Domain Potassium (K2P) Channel Trek-1 Promotes Hyperoxia-Induced Acute Lung injury. Journal of Critical Care Medicine 2013, (J Crit Care Med, submitted).
- Roan, E, Waters, CM, Teng, B, Ghosh, M, and Schwingshackl, A The 2-Pore Domain Potassium Channel TREK-1 Regulates Stretch-induced Detachment of Alveolar Epithelial Cells. (PLoS ONE 9(2): e89429.
Awards and Grants
- NIH/K12 award, 2013-14
- NIH/K08, 2014-18
- American Lung Association Biomedical Research Grant, 2013-15
- Le Bonheur faculty award for Excellence in Research, 2013
- Associate Editor for Frontiers in Pediatric Critical Care
- Early Career Reviewer (ECR) at the Center for Scientific Review (CSR), National Institutes of Health (NIH)
- Co-investigator: "The Role of Steroids in Pediatric ARDS". Open, single-center study at Le Bonheur Children’s Hospital, 2010-present
Department of Pediatrics
Critical Care Division
Le Bonheur Children's Hospital
50 N Dunlap, 3rd Floor
Memphis, TN 38103